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最新文章

• Functional SARS- CoV- 2 cross- reactive CD4+ T cells established in early childhood decline with age (vol 120, e2220320120, 2023) AI翻译
  作者：Humbert, Marion; Olofsson, Anna; Wullimann, David; Niessl, Julia; Hodcroft, Emma B.; Cai, Curtis; Gao, Yu; Sohlberg, Ebba; Dyrdak, Robert; Mikaeloff, Flora; Neogi, Ujjwal; Albert, Jan; Malmberg, Karl-Johan; Lund-Johansen, Fridtjof; Aleman, Soo; Bjoerkhem-Bergman, Linda; Jenmalm, Maria C.; Ljunggren, Hans-Gustaf; Buggert, Marcus; Karlsson, Annika C.
• Fatty acid metabolism and the oxidative stress response support bacterial predation AI翻译
  作者：Jain, Rikesh; Le, Nguyen - Hung; Bertaux, Lionel; Baudry, Jean; Bibette, Jerome; Denis, Yann; Habermann, Bianca H.; Mignot, Tam
  作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite
  摘要：Despite growing awareness of their importance in soil ecology, the genetic and physiological traits of bacterial predators are still relatively poorly understood. In the course of a Myxococcus xanthus predator evolution experiment, we identified a class of genotypes leading to enhanced predation against diverse species. RNA- seq analysis demonstrated that this phenotype is linked to the constitutive activation of a predation- specific program. Functional analysis of the mutations accumulated a...
• Automating the practice of science: Opportunities, challenges, and implications AI翻译
  作者：Musslick, Sebastian; Bartlett, Laura K.; Chandramouli, Suyog H.; Dubova, Marina; Gobet, Fernand; Griffiths, Thomas L.; Hullman, Jessica; King, Ross D.; Kutz, J. Nathan; Lucas, Christopher G.; Mahesh, Suhas; Pestilli, Franco; Sloman, Sabina J.; Holmes, William R.
  作者单位：University Osnabruck; Brown University; University of London; London School Economics & Political Science; Aalto University; University of Alberta; Princeton University; Indiana University System; Indiana University Bloomington; Roehampton University; Princeton University; Northwestern University; University of Cambridge; Chalmers University of Technology; University of Washington; University of Washington Seattle; University of Edinburgh; University of Toronto; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Manchester
  摘要：Automation transformed various aspects of our human civilization, revolutionizing industries and streamlining processes. In the domain of scientific inquiry, automated approaches emerged as powerful tools, holding promise for accelerating discovery, enhancing reproducibility, and overcoming the traditional impediments to scientific progress. This article evaluates the scope of automation within scientific practice and assesses recent approaches. Furthermore, it discusses different perspectives...
• NR2B subunit of the NMDA glutamate receptor regulates appetite in the parabrachial nucleus (vol 110, pg 14765, 2013) AI翻译
  作者：Wu, Qi; Zheng, Ruimao; Srisai, Dollada; McKnight, G. Stanley; Palmiter, Richard D.
• Cyanobacteria and Chloroflexota cooperate to structure light- responsive biofilms AI翻译
  作者：Bunbury, Freddy; Rivas, Carlos; Calatrava, Victoria; Malkovskiy, Andrey, V; Joubert, Lydia - Marie; Parvate, Amar D.; Evans, James E.; Grossman, Arthur R.; Bhaya, Devaki
  作者单位：University of Chicago; Carnegie Institution for Science; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; United States Department of Energy (DOE); Pacific Northwest National Laboratory; Washington State University; Stanford University
  摘要：Microbial mats are stratified communities often dominated by unicellular and filamentous phototrophs within an exopolymer matrix. It is challenging to quantify the dynamic responses of community members in situ as they experience steep gradients and rapid fluctuations of light. To address this, we developed a binary consortium using two representative isolates from hot spring mats: the unicellular oxygenic phototrophic cyanobacterium Synechococcus OS-B ' (Syn OS-B ') and the filamentous anoxyg...
• Plastic responses to past environments shape adaptation to novel selection pressures AI翻译
  作者：Coates, Sarah E. R.; Comeault, Aaron A.; Wood, Daniel P.; Fay, Michael F.; Creer, Simon; Osborne, Owen G.; Dunning, Luke T.; Papadopulos, Alexander S. T.
  作者单位：Bangor University; Royal Botanic Gardens, Kew; University of Western Australia; University of Sheffield
  摘要：Phenotypic plasticity may pave the way for rapid adaptation to newly encountered environments. Although it is often contested, there is growing evidence that initial plastic responses of ancestral populations to new environmental cues may promote subsequent adaptation. However, we do not know whether plasticity to cues present in the ancestral habitat (past- cue plasticity) can facilitate adaptation to novel cues. Conceivably, this could occur if plastic responses are coincidentally optimal to...
• Environmental variability across space and time drives the recolonization pattern of a historically persecuted large carnivore AI翻译
  作者：Moqanaki, Ehsan; Milleret, Cyril; Dupont, Pierre; Mattisson, Jenny; Dey, Soumen; Broseth, Henrik; Aronsson, Malin; Persson, Jens; Wabakken, Petter; Flagstad, Oystein; Bischof, Richard
  作者单位：Norwegian University of Life Sciences; University of Montana System; University of Montana; Norwegian Institute Nature Research; Swedish University of Agricultural Sciences; Inland Norway University of Applied Sciences
  摘要：Wildlife populations are not static. Intrinsic and extrinsic factors affect individuals, which lead to spatiotemporal variation in population density and range. Yet, dynamics in density and their drivers are rarely documented, due in part to the inherent difficulty of studying long-term population-level phenomena at ecologically meaningful scales. We studied the spatiotemporal density dynamics in a recolonizing large carnivore population, the wolverine Gulo gulo, across the Scandinavian Penins...
• Subunit- specific conductance of single homomeric and heteromeric HCN pacemaker channels at femtosiemens resolution AI翻译
  作者：Benndorf, Klaus; Enke, Uta; Tewari, Debanjan; Kusch, Jana; Liu, Haoran; Sun, Han; Schmauder, Ralf; Sattler, Christian
  作者单位：Friedrich Schiller University of Jena; Leibniz Association; Leibniz Forschungsinstitut furr Molekulare Pharmakologie (FMP); Technical University of Berlin
  摘要：In mammals, the four subunit isoforms HCN1-4 assemble to form functional homotetrameric and heterotetrameric hyperpolarization- activated cyclic nucleotide- modulated (HCN) ion channels. Despite the outstanding relevance of HCN channels for organisms, including generating electrical rhythmicity in cardiac pacemaker cells and diverse types of brain neurons, key channel properties are still elusive. In particular, the unitary conductance, gamma, of HCN channels is highly controversial. We analyz...
• How can we make sound replication decisions? AI翻译
  作者：Davis-Stober, Clintin P.; Sarafoglou, Alexandra; Aczel, Balazs; Chandramouli, Suyog H.; Errington, Timothy M.; Field, Sarahanne M.; Fishbach, Ayelet; Freire, Juliana; Ioannidis, John P. A.; Oberauer, Klaus; Pestilli, Franco; Ressl, Susanne; Schad, Daniel J.; ter Schure, Judith; Tentori, Katya; van Ravenzwaaij, Don; Vandekerckhove, Joachim; Gundersen, Odd Erik
  作者单位：University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Amsterdam; Eotvos Lorand University; Aalto University; Princeton University; University of Groningen; University of Chicago; New York University; New York University Tandon School of Engineering; New York University; Stanford University; Stanford University; Stanford University; Stanford University; University of Zurich; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Amsterdam; University of Trento; University of Groningen; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; Norwegian University of Science & Technology (NTNU)
  摘要：Replication and the reported crises impacting many fields of research have become a focal point for the sciences. This has led to reforms in publishing, methodological design and reporting, and increased numbers of experimental replications coordinated across many laboratories. While replication is rightly considered an indispensable tool of science, financial resources and researchers' time are quite limited. In this perspective, we examine different values and attitudes that scientists can c...
• Bubble coalescence principle in saline water AI翻译
  作者：Li, Danlong; Manica, Rogerio; Chen, Zhixiang; Wang, Shuo; Liu, Qingxia; Zhang, Haijun
  作者单位：China University of Mining & Technology; Shenzhen Technology University; University of Alberta
  摘要：Bubbles present in saline water typically exhibit a prolonged lifetime, making them attractive for various engineering processes. Herein, we unveil a transition from delayed bubble coalescence to rapid bursting within about one millisecond in salty solutions. The key aspect in understanding this transition lies in the combined influences of surface deformation and ion surface excess instead of characterizing the ions alone. Only with a sufficiently deformed region trapped between the colliding...