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最新文章

• Triethylamine- mediated protonation-deprotonation unlocks dual- drug self assembly to suppress breast cancer progression and metastasis AI翻译
  作者：Lei, Lei; Song, Yujun; Yang, Lianyi; Wang, Yazhen; Xia, Xue; Zhang, Yiwei; Zhang, Xiaoxian; Zhang, Xuequan; Duggal, Ishaan; He, Bin; Peppas, Nicholas A.; Cao, Jun; Gao, Huile
  作者单位：Sichuan University; Sichuan University; Sichuan University; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：Carrier- free nanomedicines exhibited significant potential in elevating drug efficacy and safety for tumor management, yet their self assembly typically relied on chemical modifications of drugs or the incorporation of surfactants, thereby compromising the drug's inherent pharmacological activity. To address this challenge, we proposed a triethylamine (TEA)- mediated protonation-deprotonation strategy that enabled the adjustable- proportion self assembly of dual drugs without chemical modific...
• Discourse on measurement AI翻译
  作者：Pedersen, Arthur Paul; Kellen, David; Mayo-Wilson, Conor; Davis-Stober, Clintin P.; Dunn, John C.; Khan, M. Ali; Stinchcombe, Maxwell B.; Kalish, Michael L.; Tentori, Katya; Haaf, Julia
  作者单位：City University of New York (CUNY) System; Syracuse University; University of Washington; University of Washington Seattle; University of Missouri System; University of Missouri Columbia; University of Western Australia; Johns Hopkins University; University of Trento; University of Potsdam
  摘要：Measurement literacy is required for strong scientific reasoning, effective experimental design, conceptual and empirical validation of measurement quantities, and the intelligible interpretation of error in theory construction. This discourse examines how issues in measurement are posed and resolved and addresses potential misunderstandings. Examples drawn from across the sciences are used to show that measurement literacy promotes the goals of scientific discourse and provides the necessary ...
• Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery AI翻译
  作者：Xu, Yue; Gong, Fanglin; Golubovic, Alex; Strilchuk, Amy; Chen, Jingan; Zhou, Muye; Dong, Songtao; Seto, Breanna; Li, Bowen
  作者单位：University of Toronto; University of Toronto; University of Toronto; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre
  摘要：The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthe-sized through complex, multistep chemical processes that are both time- consuming and require significant engineering. Furthermore, the development of new ionizable lipids is hindered by a limited understanding of the structure- activity relationships essential for effective mRNA delivery. In this work, we have developed...
• Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain AI翻译
  作者：Bagnoli, Enrico; Lin, Yu- En; Burel, Sophie; Jaimon, Ebsy; Antico, Odetta; Themistokleous, Christos; Nikoloff, Jonas M.; Squires, Samuel; Morella, Ilaria; Watzlawik, Jens O.; Fiesel, Fabienne C.; Springer, Wolfdieter; Tonelli, Francesca; Lis, Pawel; Brooks, Simon P.; Dunnett, Stephen B.; Brambilla, Riccardo; Alessi, Dario R.; Pfeffer, Suzanne R.; Muqit, Miratul M. K.
  作者单位：University of Dundee; Stanford University; University of Pavia; Cardiff University; Mayo Clinic; Mayo Clinic; Cardiff University
  摘要：Mutations in Leucine- rich repeat kinase 2 (LRRK2) and PTEN- induced kinase 1 (PINK1) are associated with familial Parkinson's disease (PD). LRRK2 phosphorylates Rab guanosine triphosphatase (GTPases) within the Switch II domain while PINK1 directly phosphorylates Parkin and ubiquitin (Ub) and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we have crossed LRRK2 [R1441C] mutant knock- in mice with PINK1 knock- out (KO) mice and report that loss of PINK1 does not impact en...
• Vulnerability to natural disasters and sustainable consumption: Unraveling political and regional differences AI翻译
  作者：Chae, Rebecca L.; Siddiqui, Rafay; Xu, Yan
  作者单位：Santa Clara University; Virginia Polytechnic Institute & State University
  摘要：The urgent calls for action on climate change underscore the importance of increasing sustainable behavior among individuals who have traditionally veered away from it, such as those on the political right. Utilizing data from four geopolitical regions across 24 countries, we explore whether vulnerability to natural disasters, brought on by either experiencing or anticipating a natural disaster, is a crucial factor. We find that as vulnerability to natural disasters increases, sustainable cons...
• Neomorphic leukemia- derived mutations in the TET2 enzyme induce genome instability via a substrate shift from 5-methylcytosine to thymine AI翻译
  作者：Jin, Guang-Bo; Rong, Shao-Qin; Yin, Dong-Rui; Deng, Zhou-Hao; Ding, Xiao; Sheng, Meng-Yao; Gao, Hai; Kohli, Rahul M.; Xu, Guo-Liang; Zhou, Dan
  作者单位：Fudan University; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Fudan University
  摘要：Ten- eleven translocation (TET) enzymes oxidize 5- methylcytosine (mC) in DNA, contributing to the regulation of gene transcription. Diverse mutations of TET2 are frequently found in various blood cancers, yet the full scope of their functional consequences has been unexplored. Here, we report that a subset of TET2 mutations identified in leukemia patients alter the substrate specificity of TET2 from acting on mC to thymine. This neomorphic activity results from substitutions at key residues i...
• Transferrin promotes fatty acid oxidation and liver tumor growth through PHD2-mediated PPARα hydroxylation in an iron- dependent manner AI翻译
  作者：Qian, Xu; Zhou, Qimin; Ouyang, Yuan; Wu, Xiaohong; Sun, Xue; Wang, Shuo; Duan, Yuran; Hu, Zhiqiang; Hou, Yueru; Wang, Zheng; Chen, Xiaohan; Wang, Katherine L.; Shen, Yuli; Dong, Bofei; Lin, Yanni; Wen, Ting; Tian, Qi; Guo, Zhanpeng; Li, Min; Xiao, Liwei; Wu, Qingang; Meng, Ying; Liu, Guijun; Ying, Hangjie; Zhou, Yahui; Zhang, Wuchang; Duan, Shengzhong; Bai, Xueli; Liu, Tong; Zhan, Peng; Lu, Zhimin; Xu, Daqian
  作者单位：Zhejiang Cancer Hospital; Chinese Academy of Sciences; Hangzhou Institute of Medicine, CAS; Zhejiang University; Zhejiang University; Zhejiang University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; Harbin Medical University; Harbin Medical University; Shandong University; Zhejiang University; Harbin Medical University
  摘要：Tumor cells reshape iron and lipid metabolism for their rapid proliferation. However, how tumor cells coordinate the interplay between tumor cell-specific iron homeo-stasis and lipid metabolism reprogramming to counteract energy shortages remains unclear. Here, we demonstrated that glucose deprivation in hepatocellular carci-noma (HCC) cells induced AMPK- dependent Transferrin S685 phosphorylation, which exposed Transferrin nuclear localization signal (NLS) for binding to importin alpha 7 and ...
• Optimal strategies for correcting merotelic chromosome attachments in anaphase AI翻译
  作者：Kliuchnikov, Evgenii; Marx, Kenneth A.; Barsegov, Valeri; Mogilner, Alex
  作者单位：University of Massachusetts System; University of Massachusetts Lowell; New York University; New York University
  摘要：Accurate chromosome segregation in mitosis depends on proper connections of sister chromatids, through microtubules, to the opposite poles of the early mitotic spindle. Transiently, many inaccurate connections are formed and rapidly corrected throughout the mitotic stages, but a small number of merotelic connections, in which a chromatid is connected to both spindle poles, remain lagging at the spindle's equator in anaphase. Most of the lagging chromatids are eventually moved to one or the oth...
• Bacterial sensor evolved by decreasing complexity AI翻译
  作者：Monteagudo-Cascales, Elizabet; Gavira, Jose A.; Xing, Jiawei; Velando, Felix; Matilla, Miguel A.; Zhulin, Igor B.; Krell, Tino
  作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Experimental del Zaidin (EEZ); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto Andaluz de Ciencias de la Tierra (IACT); University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Cold Spring Harbor Laboratory
  摘要：Bacterial receptors feed into multiple signal transduction pathways that regulate a variety of cellular processes including gene expression, second messenger levels, and motility. Receptors are typically activated by signal binding to ligand- binding domains (LBDs). Cache domains are omnipresent LBDs found in bacteria, archaea, and eukar-yotes, including humans. They form the predominant family of extracytosolic bacterial LBDs and were identified in all major receptor types. Cache domains are ...
• Dialogues about the practice of science AI翻译
  作者：Shiffrin, Richard M.; Trueblood, Jennifer S.; Kellen, David; Vandekerckhove, Joachim
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Syracuse University; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine