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作者：Nguyen, Ngoc Minh Phuong; Chang, Eun Mi; Chauvin, Maeva; Sicher, Natalie; Kashiwagi, Aki; Nagykery, Nicholas; Chow, Christina; May, Phoebe; Bunnell, Alana Mermin-; Cleverdon, Josephine; Duong, Thy; Kano, Motohiro; Godin, Philippe; Meinsohn, Marie- Charlotte; Gao, Dadi; Donahoe, Patricia K.; Pepin, David
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：AntiM & uuml;llerian hormone (AMH) protects the ovarian reserve from chemotherapy, and this effect is most pronounced with Doxorubicin (DOX). However, DOX toxicity and AMH rescue mechanisms in the ovary have remained unclear. Herein, we characterize the consequences of these treatments in ovarian cell types using scRNAseq. DOX- induced DNA damage activates Tp53 class mediators across ovarian cell types. In the mesenchyme, cotreatment with AMH halts theca progenitor differentiation and reduces ...
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作者：Chakraborty, Saikat; Martinez-Sanchez, Antonio; Beck, Florian; Toro-Nahuelpan, Mauricio; Hwang, In-Young; Noh, Kyung-Min; Baumeister, Wolfgang; Mahamid, Julia
作者单位：Max Planck Society; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; Max Planck Society; European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); University of Oxford; University of Murcia
摘要：The functional architecture of the long- lived neuronal microtubule (MT) cytoskeleton is maintained by various MT- associated proteins (MAPs), most of which are known to bind to the MT outer surface. However, electron microscopy (EM) has long ago revealed the presence of particles inside the lumens of neuronal MTs, of yet unknown identity and function. Here, we use cryogenic electron tomography (cryo-ET) to analyze the three- dimensional (3D) organization and structures of MT lumenal particles...
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作者：Garcia-Rebeco, Carlos; Dierick, Diego; Manser, Konstantine
作者单位：University of Connecticut; University of Bristol
摘要：Electric fields in terrestrial environments are used by caterpillars to detect their predators, as foraging cues by pollinators, and facilitate ballooning by spiders. This study shows that electric fields facilitate transportation and detection of hummingbirds in a guild of tropical phoretic mites. Hummingbird flower mites feed on nectar and pollen and complete their life cycle inside flowers. Mites colonize new flowers by hitching rides on hummingbird beaks. Flower mites emerge from hummingbi...
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作者：Nestor, Michael W.; Cordova, France; Pines, Darryll; Merfeld, Danielle; Griffiths, Jennifer; McNutt, Marcia
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作者：Bareket, Orly; Fiske, Susan T.
作者单位：Ben-Gurion University of the Negev; Princeton University; Princeton University
摘要：Traditional gendered arrangements-norms, roles, prejudi ces, and hierarchies-shape every human life. Associated harms are primarily framed as women's issues due to more severe consequences women face. Yet, gendered arrangements also shape men's relationships, career paths, and health. Current work on gender equity overlooks men's perspectives. Despite benefits they gain from out- ranking women, men's position paradoxically entraps them in restrictive roles, compelling them to prioritize domina...
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作者：Binz, Marcel; Alaniz, Stephan; Roskies, Adina; Aczel, Balazs; Bergstrom, Carl T.; Allen, Colin; Schad, Daniel; Wulff, Dirk; West, Jevin D.; Zhang, Qiong; Shiffrin, Richard M.; Gershman, Samuel J.; Popov, Vencislav; Bender, Emily M.; Marelli, Marco; Botvinick, Matthew M.; Akata, Zeynep; Schulz, Eric
作者单位：Max Planck Society; Technical University of Munich; University of California System; University of California Santa Barbara; Eotvos Lorand University; University of Washington; University of Washington Seattle; Max Planck Society; University of Basel; Rutgers University System; Rutgers University New Brunswick; Indiana University System; Indiana University Bloomington; Harvard University; University of Zurich; University of Milano-Bicocca; Alphabet Inc.; Google Incorporated; DeepMind; University of London; University College London
摘要：Large language models (LLMs) are being increasingly incorporated into scientific workflows. However, we have yet to fully grasp the implications of this integration. How should the advancement of large language models affect the practice of science? For this opinion piece, we have invited four diverse groups of scientists to reflect on this query, sharing their perspectives and engaging with LLMs is not fundamentally different from working with human collaborators, while Bender et al. argue th...
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作者：Chen, Xiaojing; Cheng, Ning; Wang, Cheng; Knierim, James J.
作者单位：Southern University of Science & Technology; Johns Hopkins University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
摘要：The hippocampal dentate gyrus (DG) is thought to orthogonalize inputs from the entorhinal cortex (pattern separation) and relay this information to the CA3 region. In turn, attractor dynamics in CA3 perform a pattern completion or error correction operation before sending its output to CA1. In a mouse model of congenital hypo-plasia of the DG, a deficiency in the Wntless (Wls) gene, specifically in cells expressing Gfap- Cre, which targets neuronal progenitors, led to an almost total absence o...
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作者：Rizo, Jason A.; Ahmad, Yakil; Pru, Jacob M.; Winuthayanon, Sarayut; Challa, Sridevi; Kim, Tae Hoon; Jeong, Jae- Wook; Spencer, Thomas E.; Kelleher, Andrew M.
作者单位：University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; Robert H. Lurie Comprehensive Cancer Center; University of Chicago; University of Chicago
摘要：Understanding how epithelial cells in the female reproductive tract (FRT) differentiate is crucial for reproductive health, yet the underlying mechanisms remain poorly defined. At birth, FRT epithelium is highly malleable, allowing differentiation into various epithelial types, but the regulatory pathways guiding these early cell fate decisions are unclear. Here, we use neonatal mouse endometrial organoids and assembloid coculture models to investigate how innate cellular plasticity and extern...
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作者：Su, Yu-Ting; Quagliato, Sydney M.; Louis, Brendyn M. St; Abdelaziz, Mohamed H.; He, Yuan; Bondage, Devanand; Lehman, Stephanie S.; Lee, Pei-Chung
作者单位：Wayne State University; Wayne State University; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
摘要：The mammalian Hippo kinases, MST1 and MST2, regulate organ development and suppress tumor formation by balancing cell proliferation and death. In macrophages, inflammasomes detect molecular patterns from invading pathogens or damaged host cells and trigger programmed cell death. In addition to lytic pyroptosis, the signa-tures associated with apoptosis are induced by inflammasome activation, but how the inflammasomes coordinate different cell death processes remains unclear. Here, we identify ...
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作者：White, Perrin C.; Miller, Walter L.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of California System; University of California San Francisco; University of California System; University of California San Francisco
