5期

最新文章

• The chloroplast RNA-binding protein CP29A supports rbcL expression during cold acclimation AI翻译
  作者：Lenzen, Benjamin; Roesch, Florian; Legen, Julia; Ruwe, Hannes; Kachariya, Nitin; Sattler, Michael; Small, Ian; Schmitz- Linneweber, Christian
  作者单位：Humboldt University of Berlin; Technical University of Munich; University of Western Australia
  摘要：The chloroplast genome encodes key components of the photosynthetic light reac-tion machinery as well as the large subunit of the enzyme central for carbon fixation, Ribulose- 1,5- bisphosphat- carboxylase/- oxygenase (RuBisCo). Its expression is predom-inantly regulated posttranscriptionally, with nuclear- encoded RNA- binding proteins (RBPs) playing a key role. Mutants of chloroplast gene expression factors often exhibit impaired chloroplast biogenesis, especially in cold conditions. Low tem...
• Poverty-disease-environment traps: Locally tailored solutions and collective action AI翻译
  作者：Barbier, Edward B.
  作者单位：Colorado State University System; Colorado State University Fort Collins
• Is Ockham's razor losing its edge? New perspectives on the principle of model parsimony AI翻译
  作者：Dubova, Marina; Chandramouli, Suyog; Gigerenzer, Gerd; Grunwaldf, Peter; Holmes, William; Lombrozo, Tania; Marelli, Marco; Musslick, Sebastian; Nicenboim, Bruno; Ross, Lauren N.; Shiffrin, Richard; White, Martha; Wagenmakers, Eric-Jan; Buerkner, Paul-Christian; Sloman, Sabina J.
  作者单位：Indiana University System; Indiana University Bloomington; Aalto University; University of Alberta; Leiden University; Leiden University - Excl LUMC; Princeton University; University of Milano-Bicocca; University Osnabruck; Brown University; Tilburg University; University of California System; University of California Irvine; Indiana University System; Indiana University Bloomington; University of Amsterdam; Dortmund University of Technology; University of Manchester
  摘要：The preference for simple explanations, known as the parsimony principle, has long guided the development of scientific theories, hypotheses, and models. Yet recent years have seen a number of successes in employing highly complex models for scientific inquiry (e.g., for 3D protein folding or climate forecasting). In this paper, we reexamine the parsimony principle in light of these scientific and technological advancements. We review recent developments, including the surprising benefits of m...
• No gender differences in attraction to young partners: A study of 4,500 blind dates AI翻译
  作者：Eastwick, Paul W.; Finkel, Eli J.; Meza, Eva M.; Ammerman, Kellie
  作者单位：University of California System; University of California Davis; Northwestern University; Northwestern University
  摘要：In mixed- gender couples, men are older than women on average. Scholars and laypeople presume that this arrangement reflects mirrored preferences such that men desire younger partners and women desire older partners. Nevertheless, relevant published data on in- person romantic evaluations-that is, studies where adults interact in person and report their initial attraction to each other-are nearly nonexistent. We examined the association of a partner's age with romantic desire (N = 9,084 dyadic...
• Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug AI翻译
  作者：Ma, Jianlong; Chen, Yang; Song, Jingmei; Ruan, Qingfeng; Li, Lianghui; Luo, Lingfei
  作者单位：Fudan University; Southwest University - China
  摘要：Aging is a complex process that affects multiple organs, and the discovery of a pharmacological approach to ameliorate aging is considered the Holy Grail of medicine. Here, we performed an N- ethyl- N- nitrosourea forward genetic screening in zebrafish and identified an accelerated aging mutant named meteor (met), harboring a mutation in the Werner syndrome RecQ- like helicase (wrn) gene. Loss of wrn leads to a short lifespan and age- related characteristics in the intestine of zebrafish embry...
• The misalignment of incentives in academic publishing and implications for journal reform AI翻译
  作者：Trueblood, Jennifer S.; Allison, David B.; Field, Sarahanne M.; Fishbach, Ayelet; Gaillard, Stefan D. M.; Gigerenzer, Gerd; Holmes, William R.; Lewandowsky, Stephan; Matzke, Dora; Murphy, Mary C.; Musslick, Sebastian; Popov, Vencislav; Roskies, Adina L.; ter Schure, Judith; Teodorescu, Andrei R.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Groningen; University of Chicago; Radboud University Nijmegen; Max Planck Society; Indiana University System; Indiana University Bloomington; University of Bristol; University of Potsdam; University of Amsterdam; Indiana University System; Indiana University Bloomington; University Osnabruck; Brown University; University of Zurich; University of California System; University of California Santa Barbara; Technion Israel Institute of Technology
  摘要：For most researchers, academic publishing serves two goals that are often misaligned-knowledge dissemination and establishing scientific credentials. While both goals can encourage research with significant depth and scope, the latter can also pressure scholars to maximize publication metrics. Commercial publishing companies have capitalized on the centrality of publishing to the scientific enterprises of knowledge dissemination and academic recognition to extract large profits from academia b...
• Chronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response AI翻译
  作者：Wang, Ting; Wang, Xiangyu; Wang, Keke; Yu, Mengyuan; Bai, Ruihua; Zhang, Yiru; Zhang, Zihan; Liu, Feifei; Wang, Rui; Shi, Xiaodan; Jia, Ludan; Liu, Kangdong; Li, Xiang; Jin, Guoguo; Zhao, Simin; Dong, Zigang
  作者单位：Zhengzhou University; Zhengzhou University; Zhengzhou University; Zhengzhou University; Zhengzhou University
  摘要：Recent studies have demonstrated that chronic stress can enhance the development of multiple human diseases, including cancer. However, the role of chronic stress in esophageal carcinogenesis and its underlying molecular mechanisms remain unclear. This study uncovered that dysregulated cholesterol metabolism significantly promotes esophageal carcinogenesis under chronic stress conditions. Our findings indicate that the persistent elevation of glucocorticoids induced by chronic stress stimulate...
• Errors are robustly tamed in cumulative knowledge processes AI翻译
  作者：Brandenberger, Anna; Marcussen, Cassandra; Mossel, Elchanan; Sudan, Madhu
  作者单位：Massachusetts Institute of Technology (MIT); Harvard University
  摘要：As knowledge accumulates in science and society in a distributed fashion, erroneous derivations can be introduced into the corpus of knowledge. Such derivations can compromise the validity of any units of knowledge that rely on them in the future. Can societal knowledge maintain some level of integrity given simple distributed error- checking mechanisms? In this paper, we investigate the following formulation of the question: assuming that a constant fraction of the new derivations is wrong, i...
• Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease AI翻译
  作者：Feng, Yue; Goncalves, Monica M.; Jitkova, Yulia; Keszei, Alexander F. A.; Yan, Yongran; Sarathy, Chaitra; St-Germain, Jonathan; Kenney, Tristan M. G.; Tcheng, Matthew; Trudel, Vincent; Mancini, Ross S.; Upadhyay, Rahul; Hurren, Rose; Gronda, Marcela; Schultz, Matthew; Soriano, Kaylen; Lees, Kaitlin; Pomroy, Neil C.; Currie, S. Quinn W.; Prive, Gilbert G.; Reed, Mark A.; Yudin, Andrei K.; Penn, Linda Z.; Arrowsmith, Cheryl H.; Raught, Brian; Mazhab-jafari, Mohammad T.; Vahidi, Siavash; Schimmer, Aaron D.
  作者单位：University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; University of Guelph; University of Toronto; Krembil Research Institute; University of Toronto; University Health Network Toronto; University of Toronto; University of Toronto; Structural Genomics Consortium
  摘要：ClpXP is a two- component mitochondrial matrix protease. The caseinolytic mitochondrial matrix peptidase chaperone subunit X (ClpX) recognizes and translocates protein substrates into the degradation chamber of the caseinolytic protease P (ClpP) for proteolysis. ClpXP degrades damaged respiratory chain proteins and is necessary for cancer cell survival. Despite the critical role of ClpXP in mitochondrial protein quality control, the specific degrons, or modifications that tag substrate protein...
• Reply to Machida et al.: Although embryology cannot establish the Protura- sister, phylogenomics can AI翻译
  作者：Du, Shiyu; Tihelka, Erik; Yu, Daoyuan; Chen, Wan-Jun; Bu, Yun; Cai, Chenyang; Engel, Michael S.; Luan, Yun-Xia; Zhang, Feng
  作者单位：Nanjing Agricultural University; Chinese Academy of Sciences; University of Cambridge; Nanjing Agricultural University; American Museum of Natural History (AMNH); Universidad Nacional Mayor de San Marcos; Universidad Nacional Mayor de San Marcos; South China Normal University