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最新文章

• Efficient, scalable, and near- nucleotide- resolution profiling of protein occupancy in the genome with deaminases AI翻译
  作者：Chang, Lei; Ren, Bing
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego
• Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis AI翻译
  作者：Jiang, Wei I.; Cao, Yiming; Xue, Yue; Ji, Yichun; Winer, Benjamin Y.; Chandra, Rashmi; Zhang, Xingyuan Fischer; Zhang, Mengqi; Singhal, Neel S.; Pierce, Jonathan T.; Chen, Song; Ma, Dengke K.
  作者单位：University of California System; University of California Berkeley; University of California San Francisco; China Pharmaceutical University; Memorial Sloan Kettering Cancer Center; Howard Hughes Medical Institute; University of California System; University of California San Francisco; University of Texas System; University of Texas Austin; University of California System; University of California San Francisco; University of California System; University of California Berkeley
  摘要：The 84 variant of human apolipoprotein E (APOE4) is a key genetic risk factor for neurodegeneration in Alzheimer's disease and elevated all- cause mortality in humans. Understanding the factors and mechanisms that can mitigate the harmful effects of APOE4 has significant implications. In this study, we find that inactivating the VHL- 1 (Von Hippel-Lindau) protein can suppress mortality, neural and behavioral pathologies caused by transgenic human APOE4 in Caenorhabditis elegans. The protective...
• Design of a light and Ca2+ switchable organic-peptide hybrid AI翻译
  作者：Khaleel, Zinah Hilal; No, Young Hyun; Kim, Nam Hyeong; Bae, Do Hyun; Wu, Yibing; Kim, Suhyeon; Choi, Hojae; Lee, Da Eun; Jeong, Se Yun; Ko, Yoon-Joo; Kim, Seong-Gi; Suh, Minah; Kim, Jin-Chul; Degrado, William F.; Kim, Ki Hyun; Kim, Yong Ho
  作者单位：Sungkyunkwan University (SKKU); Institute for Basic Science - Korea (IBS); Sungkyunkwan University (SKKU); University of California System; University of California San Francisco; University of California System; University of California San Francisco; Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Seoul National University (SNU); Korea Institute of Science & Technology (KIST); Sungkyunkwan University (SKKU)
  摘要：The design of organic-peptide hybrids has the potential to combine our vast knowledge of protein design with small molecule engineering to create hybrid structures with complex functions. Here, we describe the computational design of a photoswitchable Ca2+- binding organic-peptide hybrid. The designed molecule, designated Ca2+- binding switch (CaBS), combines an EF- hand motif from classical Ca2+- binding proteins such as calmodulin with a photoswitchable group that can be reversibly isomerize...
• Embryology cannot establish the Protura- sister AI翻译
  作者：Machida, Ryuichiro; Fukui, Makiko; Tomizuka, Shigekazu; Ikeda, Yatsukaho; Sekiya, Kaoru; Masumoto, Mika
  作者单位：University of Tsukuba; Ehime University; Oita University; University of Tsukuba; Kitasato University
• Managing protected areas takes a village AI翻译
  作者：Burivalova, Zuzana; Rakotonarivo, O. Sarobidy
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; University Antananarivo
• Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration (2006; 10.1073/pnas.0605077103 (Proc. Natl. Acad. Sci. U.S.A.103 , 18326-18331) AI翻译
  作者：Luo, Jian; Lin, Amy H.; Masliah, Eliezer; Wyss-Coray, Tony
• SIV monoclonal antibody administration spanning treatment interruption in macaques delays viral rebound and selects escape variants AI翻译
  作者：King, Hannah A. D.; Brammer, Daniel; Lewitus, Eric; Fennessey, Christine M.; Manalang, Kimberly M.; Shrader, Hannah R.; Andrew, Shayne; Kuri, Phillip; Lind, Matthew; Pham, Phuc; Sanders-Buell, Eric; Bai, Hongjun; Mason, Rosemarie; Song, Kaimei; Mccarthy, Elizabeth; Hait, Sabrina Helmold; Todd, John - Paul; Pegu, Amarendra; Foulds, Kathryn E.; Lifson, Jeffrey D.; Keele, Brandon F.; Rolland, Morgane; Roederer, Mario; Bolton, Diane L.
  作者单位：Walter Reed Army Institute of Research (WRAIR); United States Department of Defense; United States Army; Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
  摘要：HIV- 1 envelope broadly neutralizing antibodies represent a promising component of HIV- 1 cure strategies. To evaluate the therapeutic efficacy of combination monoclonal antibodies (mAbs) in a rigorous nonhuman primate model, we tested different combinations of simian immunodeficiency virus (SIV) neutralizing mAbs in SIVmac251- infected rhesus macaques. Antiretroviral therapy- suppressed animals received anti-SIV mAbs targeting multiple Env epitopes spanning analytical treatment interruption (...
• PgpP is a broadly conserved phosphatase required for phosphatidylglycerol lipid synthesis AI翻译
  作者：Grundling, Angelika; Brogan, Anna P.; James, Michael J.; Ramirez-Guadiana, Fernando H.; Roney, Ian J.; Bernhardt, Thomas G.; Rudner, David Z.
  作者单位：Imperial College London; Imperial College London; Harvard University; Harvard Medical School; Howard Hughes Medical Institute
  摘要：The cytoplasmic membrane of bacteria is composed of a phospholipid bilayer made up of a diverse set of lipids. Phosphatidylglycerol (PG) is one of the principal constituents and its production is essential for growth in many bacteria. All the enzymes required for PG biogenesis in Escherichia coli have been identified and characterized decades ago. However, it has remained poorly understood how gram- positive bacteria perform the terminal step in the pathway that produces this essential lipid. ...
• Growth decline in European beech associated with temperature- driven increase in reproductive allocation AI翻译
  作者：Hacket-Pain, Andrew; Szymkowiak, Jakub; Journe, Valentin; Barczyk, Maciej K.; Thomas, Peter A.; Lageard, Jonathan G. A.; Kelly, Dave; Bogdziewicz, Michal
  作者单位：University of Liverpool; Adam Mickiewicz University; Adam Mickiewicz University; Keele University; Manchester Metropolitan University; University of Canterbury
  摘要：Climate change is impacting forests in complex ways, with indirect effects arising from interactions between tree growth and reproduction often overlooked. Our 43- y study of European beech (Fagus sylvatica) showed that rising summer temperatures since 2005 have led to more frequent seed production events. This shift increases reproductive effort but depletes the trees' stored resources due to insufficient recovery periods between seed crops. Consequently, annual tree ring increments have decl...
• A pentatomomorpha- specific salivary protein activates plant immunity and is critical for insect feeding AI翻译
  作者：Hu, Biao; Feng, Xiuli; Xu, Manru; Huang, Yue; Guo, Chunyun; Yuan, Ruikun; Li, Yiyuan; Wei, Zhongyan; Chen, Jianping; Sun, Zongtao
  作者单位：Ningbo University
  摘要：The stinkbug Riptortus pedestris, notorious for inducing soybean staygreen-like syndrome, employs a range of salivary proteins to manipulate the host plant for its benefit. Here, we show that RpSP1, a salivary protein specific to Pentatomomorpha, triggers plant defense responses in multiple plant species. RpSP1 interacts with and stabilizes a HSP40 family protein GmSPIP1 and is dependent on GmSPIP1 to induce cell death. We show that a critical 22-amino acid peptide within RpSP1 acts as an intr...