5期

最新文章

• How towns can adapt to fire as bigger burns loom AI翻译
  作者：Mcdermott, Amy
• Structural insights into the assembly and energy transfer of haptophyte photosystem I-light-harvesting supercomplex (vol 121, e2413678121, 2024) AI翻译
  作者：He, Fei-Yu; Zhao, Long-Sheng; Qu, Xin-Xiao; Li, Kang; Guo, Jian-Ping; Zhao, Fang; Wang, Ning; Qin, Bing-Yue; Chen, Xiu-Lan; Gao, Jun; Liu, Lu-Ning; Zhang, Yu-Zhong
• Retinoic acid antagonizes estrogen signaling to maintain adult uterine cell fate AI翻译
  作者：Yin, Yan; Haller, Meade; Goldinger, Lauren; Bharadwaj, Shivani; So, Emily; Robles-Pinos, Vivian; Chen, David; Ma, Liang
  作者单位：Washington University (WUSTL)
  摘要：Classical tissue recombination experiments demonstrate that cell- fate determination along the anterior-posterior axis of the M & uuml;llerian duct occurs prior to postnatal day 7 in mice. However, little is known about how these cell types are maintained in adults. In this study, we provide genetic evidence that a balance between antagonistic retinoic acid (RA) and estrogen signaling activity is required to maintain simple columnar cell fate in adult uterine epithelium. Transdifferentiation o...
• The actin filament pointed- end depolymerase Srv2/CAP depolymerizes barbed ends, displaces capping protein, and promotes formin processivity AI翻译
  作者：Towsif, Ekram M.; Shekhar, Shashank
  作者单位：Emory University
  摘要：Cellular actin networks exhibit distinct assembly and disassembly dynamics, primarily driven by multicomponent reactions occurring at the two ends of actin filaments. While barbed ends are recognized as the hotspot for polymerization, depolymerization is predominantly associated with pointed ends. Consequently, mechanisms promoting barbed- end depolymerization have received relatively little attention. Here, using microfluidics- assisted three- color single- molecule imaging, we reveal that cy...
• Unconventional magnetic oscillations in a kagome Mott insulator AI翻译
  作者：Zheng, Guoxin; Zhu, Yuan; Chen, Kuan-Wen; Kang, Byungmin; Zhang, Dechen; Jenkins, Kaila; Chan, Aaron; Zeng, Zhenyuan; Xu, Aini; Valenzuela, Oscar A.; Blawat, Joanna; Singleton, John; Li, Shiliang; Lee, Patrick A.; Li, Lu
  作者单位：University of Michigan System; University of Michigan; Massachusetts Institute of Technology (MIT); Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; United States Department of Energy (DOE); Los Alamos National Laboratory; Songshan Lake Materials Laboratory
  摘要：In metals, electrons in a magnetic field undergo cyclotron motion, leading to oscillations in physical properties called quantum oscillations. This phenomenon has never been seen in a robust insulator because there are no mobile electrons. We report an exception to this rule. We study a Mott insulator on a kagome lattice which does not order magnetically down to milli-Kelvin temperatures despite antiferromagnetic interactions. We observe a plateau at magnetization equal to 9 1Bohr magneton per...
• A planar- sheet nongraphitic zero- bandgap sp2 carbon phase made by the low- temperature reaction of γ- graphyne AI翻译
  作者：Aliev, Ali E.; Guo, Yongzhe; Fonseca, Alexandre F.; Razal, Joselito M.; Wang, Zhong; Galvao, Douglas S.; Bolding, Claire M.; Chapman-Wilson, Nathaniel E.; Desyatkin, Victor G.; Leisen, Johannes E.; Ribeiro Jr, Luiz A.; Kanegae, Guilherme B.; Lynch, Peter; Zhang, Jizhen; Judicpa, Mia A.; Parra, Aaron M.; Zhang, Mengmeng; Gao, Enlai; Hu, Lifang; Rodionov, Valentin O.; Baughman, Ray H.
  作者单位：University of Texas System; University of Texas Dallas; Wuhan University; Universidade Estadual de Campinas; Deakin University; University System of Ohio; Case Western Reserve University; University System of Georgia; Georgia Institute of Technology; Universidade de Brasilia; Universidade de Brasilia; Commonwealth Scientific & Industrial Research Organisation (CSIRO); University of Texas System; University of Texas Dallas
  摘要：The highest sheet symmetry form of graphyne, with one triple bond between each neighboring hexagon in graphene, irreversibly transforms exothermically at ambient pressure and low temperatures into a nongraphitic, planar- sheet, zero- bandgap phase consisting of intrasheet- bonded sp2 carbons. The synthesis of this sp2 carbon phase is demonstrated, and other carbon phases are described for possible future synthesis from graphyne without breaking graphyne bonds. While measurements and theory ind...
• Circadian clock cryptochrome proteins regulate autoimmunity (vol 114, pg 12548, 2017) AI翻译
  作者：Cao, Qi; Zhao, Xuan; Bai, Jingwen; Gery, Sigal; Sun, Haibo; Lin, De-Chen; Chen, Qi; Chen, Zhengshan; Mack, Lauren; Yang, Henry; Deng, Ruishu; Shi, Xianping; Chong, Ling-Wa; Cho, Han; Xie, Jianjun; Li, Quan-Zhen; Muschen, Markus; Atkins, Annette R.; Liddle, Christopher; Yu, Ruth T.; Alkan, Serhan; Said, Jonathan W.; Zheng, Ye; Downes, Michael; Evans, Ronald M.; Koeffler, H. Philip
• 14-3-3 promotes sarcolemmal expression of cardiac CaV1.2 and nucleates isoproterenol-triggered channel superclustering AI翻译
  作者：Spooner, Heather C.; Costa, Alexandre D.; Westhoff, Maartje; Hernandez-Gonzalez, Adriana; Ibrahimkhail, Husna; Yarov-Yarovoy, Vladimir; Horne, Mary C.; Dickson, Eamonn J.; Dixon, Rose E.
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis; University of California System; University of California Davis
  摘要：The L- type Ca2+ channel (Ca(V)1.2) is essential for cardiac excitation-contraction coupling. To contribute to the inward Ca2+ flux that drives Ca2+- induced- Ca2+- release, Ca(V)1.2 channels must be expressed on the sarcolemma; thus the regulatory mechanisms that tune Ca(V)1.2 expression to meet contractile demand are an emerging area of research. A ubiquitously expressed protein called 14- 3- 3 has been proposed to affect Ca2+ channel trafficking in nonmyocytes; however, whether 14- 3- 3 has...
• Strong precursor softening in cubic CaSiO3 perovskite AI翻译
  作者：Zhang, Chi; Yang, Jin-Yuan; Sun, Tao; Zhang, Huai; Brodholt, John P.
  作者单位：Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of London; University College London; University of Oslo
  摘要：CaSiO3 perovskite (CaPv) is the last major mineral in the Earth's lower mantle whose elasticity remains largely unresolved. Here, we investigate the elasticity of CaPv using ab initio machine-learning force fields (MLFF). At room temperature, the elasticity of tetragonal CaPv determined by MLFF molecular dynamics (MD) agrees well with experimental measurements after considering temperature induced variations in the hydrostatic structure, proving the effectiveness of the method. We use the MLFF...
• Organismal complexity strongly correlates with the number of protein families and domains AI翻译
  作者：Ponce, David; Krishnamurthy, Subramanian
  作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers Cancer Institute of New Jersey
  摘要：In the pregenomic era, scientists were puzzled by the observation that haploid genome size (the C- value) did not correlate well with organismal complexity. This phenomenon, called the C- value paradox, is mostly explained by the fact that protein- coding genes occupy only a small fraction of eukaryotic genomes. When the first genome sequences became available, scientists were even more surprised by the fact that the number of genes (G- value) was also a poor predictor of complexity, which gav...