Fatty acid metabolism and the oxidative stress response support bacterial predation

• 成果类型: Article
• 署名作者: Jain, Rikesh; Le, Nguyen - Hung; Bertaux, Lionel; Baudry, Jean; Bibette, Jerome; Denis, Yann; Habermann, Bianca H.; Mignot, Tam
• 署名单位: Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Aix-Marseille Universite
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8524
• DOI: 10.1073/pnas.2420875122
• 发表日期: 2025-02-04
• 关键词: myxococcus; generation

摘要

Despite growing awareness of their importance in soil ecology, the genetic and physiological traits of bacterial predators are still relatively poorly understood. In the course of a Myxococcus xanthus predator evolution experiment, we identified a class of genotypes leading to enhanced predation against diverse species. RNA- seq analysis demonstrated that this phenotype is linked to the constitutive activation of a predation- specific program. Functional analysis of the mutations accumulated across the evolutionary time in a two- component system and Acyl- CoA- manipulating enzymes revealed the critical roles of fatty acid metabolism and antioxidant gene induction. The former likely adapts the predator to metabolites derived from the prey while the latter protects predatory cells from reactive oxygen species generated by prey cells under stress and released upon lysis during predation. These findings reveal interesting parallels between bacterial predator-prey dynamics and pathogen-host cell interactions.