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作者：Doruska, Molly J.; Barrett, Christopher B.; Rohr, Jason R.
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作者：Shibata, Kengo; Chen, Cheng; Tai, Xin You; Manohar, Sanjay G.; Husain, Masud
作者单位：University of Oxford; University of Oxford; Oxford University Hospitals NHS Foundation Trust; University of Oxford
摘要：The effects of apolipoprotein E (APOE) and Klotho genes, both implicated in aging, on human cognition as a function of sex and age are yet to be definitively established. Here, we showed in the largest cohort studied to date (N = 320,861) that APOE homozygous epsilon 4 carriers had a greater decline in cognition with aging compared to epsilon 3 carriers (epsilon 3/epsilon 4 and epsilon 3/epsilon 3) as well as smaller hippocampi and amygdala (N = 29,510). Critically, sex and age differentially ...
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作者：Singh, Vikram Pal; Li, Jingwen; Dawson, Kana; Mitchell, Jude F.; Miller, Cory T.
作者单位：University of California System; University of California San Diego; University of Rochester; University of California System; University of California San Diego
摘要：Our understanding of how vision functions as primates actively navigate the real- world is remarkably sparse. As most data have been limited to chaired and typically head- restrained animals, the synergistic interactions of different motor actions/plans inherent to active sensing-e.g., eyes, head, posture, movement, etc.-on visual perception are largely unknown. To address this considerable gap in knowledge, we developed an innovative wireless head- mounted eye- tracking system that performs C...
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作者：Huang, Zijue; Ghosh, Kingshuk; Stull, Frederick; Horowitz, Scott
作者单位：University of Denver; University of Denver; University of Denver; Western Michigan University
摘要：Many proteins have slow folding times in vitro that are physiologically untenable. To combat this challenge, ATP- dependent chaperonins are thought to possess the unique ability to catalyze protein folding. Performing quantitative model selection using protein folding and unfolding data, we here show that short nucleic acids containing G- quadruplex (G4) structure can also catalyze protein folding. Performing the experiments as a function of temperature demonstrates that the G4 reshapes the un...
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作者：Aubrun, Cecilia; Morel, Rudy; Benzaquen, Michael; Bouchaud, Jean-Philippe
作者单位：Institut Polytechnique de Paris; Ecole Polytechnique; Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Simons Foundation; Flatiron Institute
摘要：We introduce an unsupervised classification framework that leverages a multiscale wavelet representation of time-series and apply it to stock price jumps. In line with previous work, we recover the fact that time-asymmetry of volatility is the major feature that separates exogenous, news-induced jumps from endogenously generated jumps. Local mean-reversion and trend are found to be two additional key features, allowing us to identify new classes of jumps. Using our wavelet-based representation...
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作者：Biswas, Souvick; Paul, Dababrata; Mondal, Koushik; Kaiser, Ralf I.
作者单位：University of Hawaii System; University of Hawaii Manoa
摘要：Atmospheric freezing of water droplets suspended in air followed by cloud formation and precipitation represent fundamental steps of the terrestrial water cycle. These aqueous droplets exhibit distinct freezing mechanisms and thermodynamic requirements com-pared to bulk water often forming metastable supercooled water at subzero temperatures on the Celsius scale (<273 K) prior to crystallization. Here, we report on a real- time spectroscopic investigation combined with simultaneous visualizati...
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作者：Boldgiv, Bazartseren; Lkhagva, Ariuntsetseg; Edwards, Scott; Stenseth, Nils C.; Bayarsaikhan, Jamsranjav; Altangerel, Dondog; Usukhjargal, Dorj; Dovchin, Badamgarav; Gombobaatar, Sundev; Batsaikhan, Nyamsuren; Warinner, Christina; Hart, Isaac; Galbreath, Kurt; Greiman, Stephen E.; Malaney, Jason; Murdoch, James D.; Mclean, Bryan; Dewitte, Sharon N.; Manzitto-Tripp, Erin; Chin, Karen; Karim, Talia S.; Simpson, Carl; Stevens, Nancy J.; Dunnum, Jonathan L.; Cook, Joseph A.; Taylor, William Timothy Treal
作者单位：National University of Mongolia; Harvard University; Harvard University; University of Oslo; Mongolian Academy of Sciences; Max Planck Society; Harvard University; Max Planck Society; Utah System of Higher Education; University of Utah; Northern Michigan University; University System of Georgia; Georgia Southern University; University of Vermont; University of North Carolina; University of North Carolina Greensboro; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of Colorado System; University of Colorado Boulder; University of New Mexico; University of New Mexico
摘要：Amid global challenges like climate change, extinctions, and disease epidemics, science and society require nuanced, international solutions that are grounded in robust, interdisciplinary perspectives and datasets that span deep time. Natural history collections, from modern biological specimens to the archaeological and fossil records, are crucial tools for understanding cultural and biological processes that shape our modern world. At the same time, natural history collections in low and mid...
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作者：Deng, Liangzi; Wang, Busheng; Halbert, Clayton; Schulze, Daniel J.; Gooch, Melissa; Bontke, Trevor; Kuo, Ting-Wei; Shi, Xin; Song, Shaowei; Salke, Nilesh; Yang, Hung- Duen; Ren, Zhifeng; Hemley, Russell J.; Zurek, Eva; Prasankumar, Rohit P.; Chu, Ching- Wu
作者单位：University of Houston System; University of Houston; University of Houston System; University of Houston; State University of New York (SUNY) System; University at Buffalo, SUNY; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; National Sun Yat Sen University; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Intellectual Ventures
摘要：In light of breakthroughs in superconductivity under high pressure, and considering that record critical temperatures (Tcs) across various systems have been achieved under high pressure, the primary challenge for higher T-c should no longer solely be to increase T-c under extreme conditions but also to reduce, or ideally eliminate, the need for applied pressure in retaining pressure-induced or -enhanced superconductivity. The topological semiconductor Bi0.5Sb1.5Te3 (BST) was chosen to demonstr...
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作者：Lee, Seunghyun; Shin, Aram; Park, Jinwoo; Yun, Sowon; Kim, Minseong; Lee, Dong Woog; Kim, Byeong-Su
作者单位：Ulsan National Institute of Science & Technology (UNIST); Yonsei University
摘要：Anion-1t interactions are crucial in various biological processes, such as enzyme catalysis and ion transport. Despite their significance, the exploitation of anion-1t interactions in synthetic polymer systems remains underexplored. This study investigates anion-1t interactions using chemically well- defined peptidomimetics guided by the composition of mussel foot proteins. Specifically, polyether-based polymers were designed utilizing two functional epoxide monomers-catechol acetonide glycidy...
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作者：Viegas, Jennifer
