6期

最新文章

• Abscisic acid signaling gates salt- induced responses of plant roots AI翻译
  作者：Lamers, Jasper; Zhang, Yanxia; van Zelm, Eva; Leong, Cheuk Ka; Meyer, A. Jessica; de Zeeuw, Thijs; Verstappen, Francel; Veen, Mark; Deolu-Ajayi, Ayodeji O.; Gommers, Charlotte M. M.; Testerink, Christa
  作者单位：Wageningen University & Research; Wageningen University & Research; South China Agricultural University; Utrecht University; Wageningen University & Research
  摘要：Soil salinity presents a dual challenge for plants, involving both osmotic and ionic stress. In response, plants deploy distinct yet interconnected mechanisms to cope with these facets of salinity stress. In this investigation, we observed a substantial overlap in the salt (NaCl)- induced transcriptional responses of Arabidopsis roots with those triggered by osmotic stress or the plant stress hormone abscisic acid (ABA), as anticipated. Notably, a specific cluster of genes responded uniquely t...
• The Regulatory- associated protein of target of rapamycin 1B (RAPTOR 1B) interconnects with the photoperiod pathway to promote flowering in Arabidopsis AI翻译
  作者：Urrea- Castellanos, Reynel; Calderan- Rodrigues, Maria J.; Artins, Anthony; Musialak- Lange, Magdalena; Macharanda- Ganesn, Appanna; Fernie, Alisdair R.; Wahl, Vanessa; Caldana, Camila
  作者单位：Max Planck Society; James Hutton Institute; Universidade de Sao Paulo
  摘要：The transition from vegetative to reproductive growth, or floral transition, is a tightly regulated, energy- demanding process. In Arabidopsis, the interplay of light perception and circadian rhythms detects changes in photoperiod length, accelerating flowering under long days (LD). CONSTANS (CO), a transcription factor, upregulates FLOWERING LOCUS T (FT) in leaves during dusk. The FT protein then moves to the shoot apical mer-istem, triggering the floral transition. While light and circadian ...
• Spatial propagation of temperate phages within and among biofilms AI翻译
  作者：Winans, James B.; Zeng, Lanying; Nadell, Carey D.
  作者单位：Dartmouth College; Dartmouth College; Texas A&M University System; Texas A&M University College Station
  摘要：Bacteria form groups composed of cells and a secreted polymeric matrix that controls their spatial organization. These groups-termed biofilms-can act as refuges from environmental disturbances and from biotic threats, including phages. Despite the ubiquity of temperate phages and bacterial biofilms, live propagation of temperate phages within biofilms has not been characterized on cellular spatial scales. Here, we leverage several approaches to track temperate phages and distinguish between ly...
• Long- term employment and health effects of active labor market programs (vol 121, e2411439121, 2024) AI翻译
  作者：Baekgaard, Martin; Nielsen, Soren Albeck; Rosholm, Michael; Svarer, Michael
• Prey depletion, interspecific competition, and the energetics of hunting in endangered African wild dogs, Lycaon pictus AI翻译
  作者：Creel, Scott; Redcliffe, James; Goodheart, Ben; Merkle, Johnathan Reyes de; Mwape, Henry; Matsushima, Stephanie; Dart, Chase; Banda, Kachama; Mayani, Bridget; Njobvu, Johane; Kabungo, Reuben; Mungolo, Michelo; Kabwe, Ruth; Kaseketi, Emmanuel; Donald, Will; Kaluka, Adrian; Chifunte, Clive; Maimbo, Howard; Plankenhorn, Luzy; Christianson, David; Becker, Matthew S.; Wilson, Rory P.
  作者单位：Montana State University System; Montana State University Bozeman; Swansea University; University of Wyoming
  摘要：Large herbivores are in decline in much of the world, including sub- Saharan Africa, and true apex carnivores like the lion (Panthera leo) decline in parallel with their prey. As a consequence, competitively subordinate carnivores like the African wild dog (Lycaon pictus) are simultaneously experiencing a costly reduction in resources and a beneficial reduction in dominant competitors. The net effect is not intuitively obvious, but wild dogs' density, survival, and reproduction are all low in ...
• Translation elongation defects activate the Caenorhabditis elegans ZIP-2 bZIP transcription factor-mediated toxin defense AI翻译
  作者：Kniazeva, Marina; Ruvkun, Gary
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
  摘要：The Caenorhabditis elegans bZIP transcription factor ZIP- 2 is activated by toxins or mutations that inhibit translational elongation. The zip- 2 DNA- binding protein is encoded in a downstream main open reading frame (mORF), but under normal translation elongation conditions only an upstream overlapping oORF- 1 frameshifted from mORF is translated. Mutations or toxins that slow translational elongation, but not inhibitors of translational initiation or termination, activate ZIP- 2. An mORF in...
• CO2 potentiates echinocandin efficacy during invasive candidiasis therapy via dephosphorylation of Hsp90 by Ptc2 in condensates AI翻译
  作者：Zhang, Mao; Zhao, Youzhi; Cui, Hao; Huang, Wenqiang; Xiong, Kang; Yang, Shan; Duan, Yuanyuan; He, Yong; Yang, Lianjuan; Su, Chang; Lu, Yang
  作者单位：Anhui Medical University; Anhui Medical University; Wuhan University; Anhui Medical University; Wuhan University; Tongji University
  摘要：Carbon dioxide is a signaling cue critical for fungal pathogenesis. Ptc2, a type 2C phosphoproteomic and biochemical assays, we identified Hsp90 as a direct target of Ptc2 at host CO2 concentrations and Ssb1 as a Ptc2 target protein regardless of CO2 levels in Candida albicans, the most prevalent human fungal pathogen. Ptc2 forms reversible condensates at elevated CO2, which enables the recruitment of Hsp90, but not Ssb1, to condensates, allowing efficient dephosphorylation. This process confe...
• Microtubule inner proteins of Plasmodium are essential for transmission of malaria parasites AI翻译
  作者：Hentzschel, Franziska; Binder, Annika M.; Dorner, Lilian P.; Herzel, Lea; Nuglisch, Fenja; Sema, Meslo; Roever, Katharina; He, Buyuan; Aguirre-Botero, Manuela C.; Cyrklaff, Marek; Funaya, Charlotta; Frischknecht, Friedrich
  作者单位：Ruprecht Karls University Heidelberg; German Center for Infection Research; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Ruprecht Karls University Heidelberg
  摘要：Microtubule inner proteins (MIPs) are microtubule- associated proteins that bind to tubulin from the luminal side. MIPs can be found in axonemes to stabilize flagellar beat or within cytoplasmic microtubules. Plasmodium spp. are the causative agents of malaria that feature different parasite forms across a complex life cycle with both unique and divergent microtubule-based arrays. Here, we investigate four MIPs in a rodent malaria parasite for their role in transmission to and from the mosquit...