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最新文章

• Measurement of α-synuclein as protein cargo in plasma extracellular vesicles (vol 121, e2408949121, 2024) AI翻译
  作者：Gilboa, Tal; Ter-Ovanesyan, Dmitry; Wang, Shih-Chin; Whiteman, Sara; Kannarkat, George T.; Church, George M.; Chen-Plotkin, Alice S.; Walt, David R.
• Contextual neural dynamics during time perception in the primate ventral premotor cortex AI翻译
  作者：Diaz, Hector; Bayones, Lucas; Alvarez, Manuel; Andrade-Ortega, Bernardo; Valero, Sebastian; Zainos, Antonio; Romo, Ranulfo; Rossi-Pool, Roman
  作者单位：Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico
  摘要：Understanding how time perception adapts to cognitive demands remains a significant challenge. In some contexts, the brain encodes time categorically (as long or short), while in others, it encodes precise time intervals on a continuous scale. Although the ventral premotor cortex (VPC) is known for its role in complex temporal processes, such as speech, its specific involvement in time estimation remains underexplored. In this study, we investigated how the VPC processes temporal information d...
• A 5,000-fold increase in the HAT reactivity of a nonheme FeIV=O complex simply by replacing two pyridines of the pentadentate N4Py ligand with pyrazoles AI翻译
  作者：Pal, Nabhendu; Xiong, Jin; Jahja, Mehmet; Mahri, Sami; Young Jr, Victor G.; Guo, Yisong; Swart, Marcel; Que Jr, Lawrence
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; Carnegie Mellon University; Universitat de Girona; Universitat de Girona; ICREA
  摘要：A pentadentate [N5] ligand (N2Py2Pz) based on the classic N4Py (N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine) framework has been synthesized by replacing the two pyridylmethyl arms with corresponding (N-methyl)pyrazolylmethyl units to form [N-bis(1-methyl-2-pyrazolyl)methyl-N-(bis-2-pyridylmethyl)amine] (L1). The oxidation of the iron(II) precursor (N2Py2Pz)Fe-II(OTf)(2) (1) with ((BuSO2)-Bu-t)C6H4IO at 298 K leads to the formation of the [Fe-IV(O)(N2Py2Pz)](2+) intermediate (2) with a...
• Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis AI翻译
  作者：Quach, Diana; Sharp, Marc; Ahmed, Sara; Ames, Lauren; Bhagwat, Amala; Deshpande, Aditi; Parish, Tanya; Pogliano, Joe; Sugie, Joseph
  作者单位：Seattle Children's Hospital; University of Washington; University of Washington Seattle; University of California System; University of California San Diego
  摘要：Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a significant global health threat, affecting an estimated 10.6 million people in 2022. The emergence of multidrug resistant and extensively drug resistant strains necessitates the development of novel and effective drugs. Accelerating the determination of mechanisms of action (MOAs) for these drugs is crucial for advancing TB treatment. This study introduces MycoBCP, a unique adaptation of bacterial cytological profiling (BCP) t...
• The unique reactivity of EKODE lipid peroxidation products allows in vivo detection of inflammation AI翻译
  作者：Shi, Chuan; Eskandari, Roozbeh; Zhang, Jianye; Zhang, Guofang; Li, Li; Hawkins, Deandrea; Zhu, Xiongwei; Tochtrop, Gregory P.
  作者单位：University System of Ohio; Case Western Reserve University; Duke University; University System of Ohio; Case Western Reserve University
  摘要：Lipid peroxidation is a complex biochemical process associated with oxidative stress, and its products play crucial roles in cellular signaling and the pathophysiology of many diseases. Among the diverse array of lipid peroxidation (LPO) products, epoxyketoocta-decenoic acids (EKODEs) have emerged as intriguing molecules with potential impacts on inflammatory diseases. EKODEs arise from linoleic acid reacting with reactive oxygen and nitrogen species present during inflammation. A hallmark of ...
• Human beauty illustrates the economic impact of heritable physical traits AI翻译
  作者：Hamermesh, Daniel S.; Zhang, Anwen
  作者单位：University of Texas System; University of Texas Austin; IZA Institute Labor Economics; National Bureau of Economic Research; University of Glasgow; Southwestern University of Finance & Economics - China
  摘要：Intergenerational transmission of inequality is a central question in the social sciences.We use one trait, beauty, to infer how much parents' physical characteristics transmitinequality across generations. Analyses of a large-scale longitudinal dataset in theUnited States, and a much smaller dataset of Chinese parents and children, show thatincreases in parents' looks are associated with increases in their child's looks. A largedataset of U.S. siblings shows a positive correlation of their be...
• Estimating the legibility of international borders AI翻译
  作者：Kenwick, Michael; Lim, Junghyun; Crane, Skyler; Wehrwein, Scott; Simmons, Beth A.
  作者单位：Rutgers University System; Rutgers University New Brunswick; University of North Carolina; University of North Carolina Chapel Hill; Western Washington University; University of Pennsylvania; University of Pennsylvania
  摘要：Researchers in the social sciences are interested in the consequences of institutions, increasingly on a global scale. Institutions that may be negotiated between states can have consequences at a microlevel, as local populations adjust their expectations and ulti-mately even their behavior to take institutional rules into account. However, large- scale fine- grained analyses that test for the complex evidence of such institutions locally are rare. This article focuses on a key institution: In...
• Cataract- prone variants of γD- crystallin populate a conformation with a partially unfolded N- terminal domain under native conditions AI翻译
  作者：Volz, Sara; Malone, Jadyn R.; Guseman, Alex J.; Gronenborn, Angela M.; Marqusee, Susan
  作者单位：University of California System; University of California Berkeley; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of California System; University of California Berkeley; University of California System; University of California Berkeley
  摘要：Human gamma D- crystallin, a monomeric protein abundant in the eye lens nucleus, must remain stably folded for an individual's entire lifetime to avoid aggregation and protein deposition- associated cataract formation. gamma D- crystallin contains two homologous domains, an N- terminal domain (NTD) and a C- terminal domain (CTD), which interact via a hydrophobic interface. Several familial mutations in the gamma crystallin gene are linked to congenital early- onset cataract, most of which affe...
• Adoption of improved crop varieties limited biodiversity losses, terrestrial carbon emissions, and cropland expansion in the tropics AI翻译
  作者：Baldos, Uris Lantz C.; Cisneros- Pineda, Alfredo; Fuglie, Keith O.; Hertel, Thomas W.
  作者单位：Purdue University System; Purdue University; United States Department of Agriculture (USDA)
  摘要：Research investments in crop improvements, including by national and international agricultural research centers, have made significant contributions to raising yields of staple food crops in developing countries. Although mostly intended to improve food security and rural incomes, innovations in crop production also have major implications for the environment. Building on the latest productivity estimates from historical crop improvements in developing countries and using a gridded (0.25 degr...
• The C2 domain augments Ras GTPase- activating protein catalytic activity AI翻译
  作者：Paul, Maxum E.; Chen, Di; Vish, Kimberly J.; Lartey, Nathaniel L.; Hughes, Elizabeth; Freeman, Zachary T.; Saunders, Thomas L.; Stiegler, Amy L.; King, Philip D.; Boggon, Titus J.
  作者单位：Yale University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Yale University; Yale University; Yale New Haven Hospital
  摘要：Regulation of Ras GTPases by GTPase- activating proteins (GAPs) is essential for their normal signaling. Nine of the ten GAPs for Ras contain a C2 domain immediately proximal to their canonical GAP domain, and in RasGAP (p120GAP, p120RasGAP; RASA1) mutation of this domain is associated with vascular malformations in humans. Here, we show that the C2 domain of RasGAP is required for full catalytic activity toward Ras. Analyses of the RasGAP C2- GAP crystal structure, AlphaFold models, and seque...