6期

最新文章

• Robust inattentive discrete choice AI翻译
  作者：Hansen, Lars Peter; Miao, Jianjun; Xing, Hao
  作者单位：University of Chicago; University of Chicago; Zhejiang University; Zhejiang University; Boston University; Boston University
  摘要：Rational inattention models characterize optimal decision-making in data-rich environ-ments. In such environments, it can be costly to look carefully at all of the information.Some information is much more salient for the decision at hand and merits closerscrutiny. The inattention decision model formalizes this choice and deduces how bestto navigate through the potentially vast array of data when making decisions. In therational formulation, the decision-maker commits fully to a subjective pri...
• Circadian clock control of interactions between eIF2α kinase CPC-3 and GCN1 with ribosomes regulates rhythmic translation initiation AI翻译
  作者：Preh, Ebimobowei O.; Ramirez, Manuel A.; Mohan, Sidharth; Guy, Chante R.; Bell-Pedersen, Deborah
  作者单位：Texas A&M University System; Texas A&M University College Station; Texas A&M University System; Texas A&M University College Station
  摘要：Misregulation of the activity of GCN2, the kinase that phosphorylates and inactivates translation initiation factor eIF2 alpha, has been implicated in several health disorders, underscoring the need to determine the mechanisms controlling GCN2 activation. During nutrient starvation, increased uncharged tRNA levels trigger GCN1 and GCN20 proteins to mediate the binding of uncharged tRNA to GCN2 to activate the kinase to phosphorylate eIF2 alpha. Under constant conditions, activation of the Neur...
• Top-performing girls are more impactful peer role models than boys, teachers say AI翻译
  作者：Goulas, Sofoklis; Megalokonomou, Rigissa; Sotirakopoulos, Panagiotis
  作者单位：Brookings Institution; Monash University; Curtin University
  摘要：We examine teachers' perceptions toward top-performing students and their role model influence on others in an online survey-based experiment. We randomly expose teachers to profiles of top-performing students and inquire whether they consider the profiled top performers to be influential role models. These profiles varied by gender and field of study (STEM or Non-STEM). Our findings show that teachers perceive top-performing girls as more influential peer role models compared to top- performi...
• HflX- mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria AI翻译
  作者：Majumdar, Soneya; Kashyap, Amuliya; Koripella, Ravi K.; Sharma, Manjuli R.; Hess, Kelley Hurst -; Manjari, Swati R.; Banavali, Nilesh K.; Ghosh, Pallavi; Agrawal, Rajendra K.
  作者单位：State University of New York (SUNY) System; Wadsworth Center; State University of New York (SUNY) System; Wadsworth Center; State University of New York (SUNY) System; University at Albany, SUNY; Emory University
  摘要：HflX is a highly conserved ribosome- associated GTPase implicated in rescuing stalled ribosomes and mediating antibiotic resistance in several bacteria, including macrolide- lincosamide antibiotic resistance in mycobacteria. Mycobacterial HflXs carry a distinct N- terminal extension (NTE) and a small insertion, as compared to their eubacterial homologs. Here, we present several high- resolution cryo-EM structures of mycobacterial HflX in complex with the 70S ribosome and its 50S subunit, with ...
• QnAs with Jeremy J. Michalek and Corey D. Harper AI翻译
  作者：Hardcastle, Matthew
• Microlevel structural poverty estimates for southern and eastern Africa AI翻译
  作者：Tennant, Elizabeth; Ru, Yating; Sheng, Peizan; Matteson, David S.; Barrett, Christopher B.
  作者单位：Cornell University; Asian Development Bank; Cornell University; University of Chicago; Cornell University; Cornell University; Cornell University
  摘要：For many countries in the Global South traditional poverty estimates are available only infrequently and at coarse spatial resolutions, if at all. This limits decisionmakers' and analysts' ability to target humanitarian and development interventions and makes it difficult to study relationships between poverty and other natural and human phenomena at finer spatial scales. Advances in Earth observation and machine learningbased methods have proven capable of generating more granular estimates o...
• Mec1-mediated Atg9 phosphorylation regulates the PAS recruitment of Atg9 vesicles upon energy stress AI翻译
  作者：Fan, Siyu; Dong, Shuling; Yao, Weijing; Zhang, Yi; Fan, Mingzhu; Feng, Shan; Wu, Choufei; Zhang, Liqin; Yi, Cong
  作者单位：Zhejiang University; Zhejiang University; Huzhou University; Westlake University
  摘要：Mec1 plays an essential role in both the DNA damage response and glucose starvation- induced autophagy. We recently reported that Mec1 regulates glucose starvation-induced autophagy through its direct binding to Atg13. However, the role of Mec1's kinase activity in autophagy remains unclear. In this study, we demonstrate that the kinase activity of Mec1 is required for glucose starvation-induced autophagy by regulating the phagophore assembly site (PAS) recruitment of Atg9 vesicles. Mechanisti...
• Engineering drive-selection balance for localized population suppression with neutral dynamics AI翻译
  作者：Willis, Katie; Burt, Austin
  作者单位：Imperial College London
  摘要：While the release of sterile males has been highly successful in suppressing some pest populations, it is impractical for many species due to the males disappearing after a single generation, necessitating large, repeated releases to maintain sufficient impact. Synthetic gene drives promise more efficient approaches since they can increase in frequency from rare, yet this also allows them to spread across a landscape, which may not always be desired. Between these two extremes are selectively ...
• Touching the classical scaling in penetrative convection AI翻译
  作者：Ouyang, Zhen; Wang, Qi; Li, Kai; Wen, Baole; Ding, Zijing
  作者单位：Harbin Institute of Technology; Southern University of Science & Technology; Chinese Academy of Sciences; Institute of Mechanics, CAS; New York Institute Technology
  摘要：The Cassini missions have identified the tiger stripes on Enceladus as the source of both thermal emission and plume jets. The hot spots in the tiger stripes are highly localized, and the plumes suggest active hydrothermal processes within the subglacial ocean of Enceladus. However, understanding the mechanism responsible for the heat anomalies in the tiger stripes remains a challenge. About 60 y ago, geoscientist George Veronis proposed a model for cold water oceans, along with the classical ...
• Bonobos point more for ignorant than knowledgeable social partners AI翻译
  作者：Townrow, Luke A.; Krupenye, Christopher
  作者单位：Johns Hopkins University
  摘要：Numerous uniquely human phenomena, from teaching to our most complex forms of cooperation, depend on our ability to tailor our communication to the knowledge and ignorance states of our social partners. Despite four decades of research into the theory of mind capacities of nonhuman primates, there remains no evidence that primates can communicate on the basis of their mental state attributions, to enable feats of coor-dination. Moreover, recent reevaluation of the experimental literature has q...