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作者：Peng, Yanling; Wang, Yiwen; Liu, Yuting; Fang, Xinyue; Cheng, Lin; Long, Qiming; Su, Dalu; Zhang, Tianhao; Shi, Xiaoya; Xu, Xiaodong; Xu, Qi; Wang, Nan; Zhang, Fan; Liu, Zhongjie; Xiao, Hua; Yao, Jin; Tian, Ling; Hu, Wei; Chen, Songbi; Wang, Haibo; Huang, Sanwen; Gaut, Brandon S.; Zhou, Yongfeng
作者单位：Chinese Academy of Agricultural Sciences; Agriculture Genomes Institute at Shenzhen, CAAS; Shenzhen Polytechnic University; Chinese Academy of Tropical Agricultural Sciences; Chinese Academy of Agricultural Sciences; University of California System; University of California Irvine
摘要：Hemizygous genes, which are present on only one of the two homologous chromosomes of diploid organisms, have been mainly studied in the context of sex chromosomes and sex-linked genes. However, these genes can also occur on the autosomes of diploid plants due to structural variants (SVs), such as a deletion/insertion of one allele, and this phenomenon largely unexplored in plants. Here, we investigated the genomic and epigenomic landscapes of hemizygous genes across 22 genomes with varying pro...
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作者：Schubert, Heidi L.; Li, Feng; Hill, Christopher P.; Schmidt, Eric W.
作者单位：Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah
摘要：The polyketide synthases (PKSs) in microbes and the cytoplasmic fatty acid synthases in humans (FASs) are related enzymes that have been well studied. As a result, there is a paradigm explaining in general terms how FASs repeatedly use a set of enzymatic domains to produce simple fats, while PKSs use the domains in a much more complex manner to produce pharmaceuticals and other elaborate molecules. However, most animals also have PKSs that do not conform to the rules described in microbes, inc...
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作者：Wakata, Yuki; Wang, Feng; Sun, Chao; Lohse, Detlef
作者单位：Tsinghua University; Tsinghua University; Max Planck Society
摘要：Volatile multicomponent liquid films show rich dynamics, due to the complex interplay of gradients in temperature and in solute concentrations. Here, we study the evaporation dynamics of a tricomponent liquid film, consisting of water, ethanol, and trans-anethole oil (known as ouzo'). With the preferential evaporation of ethanol, cellular convective structures are observed both in the thermal patterns and in the nucleated oil droplet patterns. However, the feature sizes of these two patterns c...
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作者：Chen, Miaomiao; Cui, Runbo; Hong, Shouqiang; Zhu, Weiwei; Yang, Qiong; Li, Jiahao; Nie, Zihan; Zhang, Xue; Ye, Yanghui; Xue, Yunxin; Wang, Dai; Hong, Yuzhi; Drlica, Karl; Niu, Jianjun; Zhao, Xilin
作者单位：Xiamen University; Xiamen University; Soochow University - China; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University Newark; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University Newark
摘要：Disinfectants are essential tools for controlling infectious diseases and maintaining sterile conditions in many medical and food- industry settings. Recent work revealed that a deficiency in the carbohydrate phosphotransferase system (PTS) confers pan- tolerance to killing by diverse disinfectant types through its interaction with the cAMP- CRP regulatory network. The present work characterized a pan- tolerance mutant obtained by enrichment using phenol as a lethal probe and an Escherichia co...
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作者：Hirth, J. P.; Anderson, P. M.
作者单位：University System of Ohio; Ohio State University
摘要：We modify the traditional linear- elastic field of an edge dislocation. The modifications stem from symmetry and energy requirements imposed in terms of embedded (deformed) coordinates. These requirements are satisfied if a line force is added to the dislocation field. The modification to the stress field is expressed by coefficients that are a function only of Poisson's ratio. Qualitatively, the field of the dislocation is increased in the glide direction and decreased in the climb direction....
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作者：Kelly, Robert L.; Mackie, Madeline E.; Pelton, Spencer R.; Robinson, Erick
作者单位：University of Wyoming; Michigan State University; University of Wyoming; Nevada System of Higher Education (NSHE); Desert Research Institute NSHE; Arizona State University; Arizona State University-Tempe
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作者：Maher, Christina; Tortolero, Lea; Jun, Soyeon; Cummins, Daniel D.; Saad, Adam; Young, James; Martinez, Lizbeth Nunez; Schulman, Zachary; Marcuse, Lara; Waters, Allison; Mayberg, Helen S.; Davidson, Richard J.; Panov, Fedor; Saez, Ignacio
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Meditation is an accessible mental practice associated with emotional regulation and well- being. Loving- kindness meditation (LKM), a specific subtype of meditative prac-tice, involves focusing one's attention on thoughts of well- being for oneself and others. Meditation has been proven to be beneficial in a variety of settings, including therapeutic applications, but the neural activity underlying meditative practices and their positive effects are not well understood. It has been difficult ...
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作者：Foley, K. Grace; Adli, Mazhar; Kim, J. Julie
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作者：Takikawa, Masahiro; Nakano, Airi; Krishnaraj, Jayaraman; Tabata, Yuko; Watanabe, Yuzo; Okabe, Atsushi; Sakaguchi, Yukiko; Fujiki, Ryoji; Mochizuki, Ami; Tajima, Tomoko; Sada, Akane; Matsushita, Shu; Wakabayashi, Yuichi; Araki, Kimi; Kaneda, Atsushi; Ishikawa, Fuyuki; Sadaie, Mahito; Ohki, Rieko
作者单位：National Cancer Center - Japan; Tokyo University of Science; Nagasaki University; Kyoto University; Chiba University; Chiba University; Chiba Cancer Center; Kumamoto University; Kumamoto University; Kyoto University
摘要：Tumor progression is suppressed by inherent cellular mechanisms such as apoptosis. The p53 tumor suppressor gene is the most commonly mutated gene in human cancer and plays a pivotal role in tumor suppression. RPRM is a target gene of p53 known to be involved in tumor suppression, but its molecular function has remained elusive. Here, we report that Reprimo (the protein product of RPRM) is secreted and extrinsically induces apoptosis in recipient cells. We identified FAT1, FAT4, CELSR1, CELSR2...
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作者：Chen, Duyu; Samajdar, Rhine; Jiao, Yang; Torquato, Salvatore
作者单位：University of California System; University of California Santa Barbara; Princeton University; Princeton University; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Princeton University; Princeton University
摘要：Classical spin liquids (CSLs) are intriguing states of matter that do not exhibit longrange magnetic order and are characterized by an extensive ground-state degeneracy. Adding quantum fluctuations, which induce dynamics between these different classical ground states, can give rise to quantum spin liquids (QSLs). QSLs are highly entangled quantum phases of matter characterized by fascinating emergent properties, such as fractionalized excitations and topological order. One such exotic quantum...
