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最新文章

• The estimated cost of preventing extinction and progressing recovery for Australia's priority threatened species AI翻译
  作者：Ward, Michelle; Possingham, Hugh P.; Wintle, Brendan A.; Woinarski, John C. Z.; Marsh, Jessica R.; Chapple, David G.; Lintermans, Mark; Scheele, Ben C.; Whiterod, Nick S.; Hoskin, Conrad J.; Aska, Bora; Yong, Chuanji; Tulloch, Ayesha; Stewart, Romola; Watson, James E. M.
  作者单位：Griffith University; University of Queensland; University of Melbourne; Charles Darwin University; University of Adelaide; Monash University; University of Canberra; Australian National University; James Cook University; University of Western Australia; Queensland University of Technology (QUT)
  摘要：The global extinction crisis is intensifying rapidly, driven by habitat loss, overexploitation, climate change, invasive species, and disease. This unprecedented loss of species not only threatens ecological integrity but also undermines ecosystem services vital for human survival. In response, many countries have set ambitious conservation targets such as halting species extinctions, yet the necessary financial commitments to achieve this are rarely prescribed. Estimating costs can be achieve...
• The ER-PM interaction is essential for cytokinesis and recruits the actin cytoskeleton through the SCAR/WAVE complex AI翻译
  作者：Xu, Zhijing; Zang, Jingze; Zhang, Xintong; Zheng, Qiwei; Li, Yifan; Field, Nadine; Fiserova, Jindriska; Hua, Bing; Qu, Xiaolu; Kriechbaumer, Verena; Deeks, Michael J.; Hussey, Patrick J.; Wang, Pengwei
  作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; Oxford Brookes University; Durham University; Yangzhou University; University of Exeter
  摘要：Plant cytokinesis requires coordination between the actin cytoskeleton, microtubules, and membranes to guide division plane formation and cell plate expansion; how these regulatory factors are coordinated remains unknown. The actin cytoskeleton assembly is controlled by several actin nucleation factors, such as the SCAR/WAVE complex, which regulates actin nucleation and branching through the activation of the ARP2/3 complex. The activity of these actin regulatory proteins is likely influenced ...
• Energyscapes pinpoint marine megafauna feeding hotspots in the Mediterranean AI翻译
  作者：Lambert, Charlotte; Broderick, Annette C.; Beton, Damla; Canadas, Ana; Dars, Cecile; Di Matteo, Andrew; Gilbert, Lola; Gimenez, Joan; Keramidas, Ioannis; Navarro, Joan; Palmer, Josie L.; Snape, Robin T. E.; Sparks, Laura; Spitz, Jerome; Tsikliras, Athanassios C.; Virgili, Auriane; Gremillet, David
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Institut Agro; Montpellier SupAgro; CIRAD; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite Paul-Valery; Universite de Montpellier; University of Exeter; Duke University; Centre National de la Recherche Scientifique (CNRS); Consejo Superior de Investigaciones Cientificas (CSIC); Spanish Institute of Oceanography; Aristotle University of Thessaloniki; Aristotle University of Thessaloniki; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Mediterraneo de Investigaciones Marinas y Ambientales (CMIMA); CSIC - Instituto de Ciencias del Mar (ICM); United States Department of Defense; United States Navy; US Navy Naval Sea Systems Command; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); University of Cape Town
  摘要：Ocean giants shape the structure and functioning of marine food webs via trophic top-down controls, landscapes of fear, vertical and horizontal redistribution of nutrients, energy, and matter. Yet, they face threats from overfishing, pollution, habitat degradation, and climate change, and one-third of marine megafauna species are at risk of extinction, ultimately endangering the resilience of entire ecosystems. In such a context, knowing when and where megafauna find resources to balance their...
• Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering AI翻译
  作者：Liao, Yunji; Ma, Hang; Wang, Zhenyu; Wang, Shusheng; He, Yang; Chang, Yunsong; Zong, Huifang; Tang, Haoneng; Wang, Lei; Ke, Yong; Cai, Huiyu; Li, Ping; Tang, Jian; Chen, Hua; Drelich, Aleksandra; Peng, Bi-Hung; Hsu, Jason; Tat, Vivian; Tseng, Chien-Te K.; Song, Jingjing; Yuan, Yunsheng; Wu, Mingyuan; Liu, Junjun; Yue, Yali; Zhang, Xiaoju; Wang, Ziqi; Yang, Li; Li, Jing; Ni, Xiaodan; Li, Hongshi; Xiang, Yuning; Bian, Yanlin; Zhang, Baohong; Yin, Haiyang; Dimitrov, Dimiter S.; Gilly, John; Han, Lei; Jiang, Hua; Xie, Yueqing; Zhu, Jianwei
  作者单位：Shanghai Jiao Tong University; Mila Quebec Artificial Intelligence Institute; University of Quebec; University of Quebec Montreal; Universite de Montreal; HEC Montreal; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; Zhengzhou University; Zhengzhou University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
  摘要：The rapid evolution of the viral genome has led to the continual generation of new variants of SARS- CoV-2. Developing antibody drugs with broad- spectrum and high efficiency is a long- term task. It is promising but challenging to develop therapeutic neutralizing antibodies (nAbs) through in vitro evolution based on antigen-antibody binding interactions. From an early B cell antibody repertoire, we isolated antibody 8G3 that retains its nonregressive neutralizing activity against Omicron BA.1...
• Light's hidden power: Vacuum fluctuations reshape superconductivity from within AI翻译
  作者：Nova, T. F.; Caviglia, A. D.
  作者单位：University of Geneva
• Biochemical and structural bases for talin ABSs-F-actin interactions AI翻译
  作者：Biertumpfel, Christian; Yamada, Yurika; Vasquez-Montes, Victor; Truong, Thien Van; Cada, A. King; Mizuno, Naoko
  作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
  摘要：Focal adhesions (FAs) are large intracellular macromolecular assemblies that play a critical role in cell polarization and migration. Talin serves as a direct connection between integrin receptor and actomyosin cytoskeleton within FAs. Talin contains three actin- binding sites (ABS1-3) that engage discreetly during the development of FAs, thus acting as a critical player in FA initiation and maturation. However, the molecular basis of the ABS-F-actin interactions remains unknown. Here, we expl...
• Variable transduction of thyroid hormone signaling in structures of the mouse brain AI翻译
  作者：Sinko, Richard; Salas-Lucia, Federico; Mohacsik, Petra; Halmos, Emese; Wittmann, Gabor; Egri, Peter; Bocco, Barbara M. L. C.; Batistuzzo, Alice; Fonseca, Tatiana L.; Fekete, Csaba; Bianco, Antonio C.; Gereben, Balazs
  作者单位：HUN-REN; HUN-REN Institute of Experimental Medicine; University of Chicago; Semmelweis University; HUN-REN; HUN-REN Institute of Experimental Medicine
  摘要：L- thyroxine (L- T4) monotherapy is the standard treatment for hypothyroidism, administered daily to normalize TSH levels. Once absorbed, T4 is converted to T3 to alleviate most symptoms. However, this treatment abnormally elevates plasma T4 levels in over 50% of patients. Using L- T4- treated Thyroid Hormone (TH) Action Indicator mice, which express a T3- regulated luciferase (Luc) reporter, we examined whether these T4 elevations disrupt TH signaling. Hypothyroid mice exhibited reduced Luc e...
• Turbulence enhances wave attenuation of seagrass in combined wave-current flows AI翻译
  作者：Vettori, Davide; Giordana, Francesco; Manes, Costantino
  作者单位：Polytechnic University of Turin
  摘要：these plants are at protecting coasts from erosion and floods. While recent studies have significantly advanced the understanding of seagrass wave attenuation in pure-wave conditions, the presence of a current introduces several complications that have yet to be fully explored. In the present study, we quantify the wave attenuation of seagrass canopies in the presence of a current parallel to the direction of wave propagation via experiments conducted with dynamically scaled mimics of seagrass...
• Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration- resistant prostate cancer AI翻译
  作者：Pitzen, Samuel P.; Rudenick, Amber N.; Qiu, Yinjie; Zhang, Weijie; Munro, Sarah A.; Mccluskey, Braedan M.; Forster, Colleen; Bergom, Hannah E.; Ali, Atef; Boytim, Ella; Lafin, John T.; Linder, Simon; Ismail, Mazlina; Devlies, Wout; Sessions, Conner J.; Claessens, Frank; Joniau, Steven; Attard, Gerhardt; Zwart, Wilbert; Nelson, Peter S.; Corey, Eva; Wang, Yuzhuo; Lang, Joshua M.; Beltran, Himisha; Strand, Douglas; Antonarakis, Emmanuel S.; Hwang, Justin; Murugan, Paari; Huang, R. Stephanie; Dehm, Scott M.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Texas System; University of Texas Southwestern Medical Center; Netherlands Cancer Institute; University of London; University College London; KU Leuven; University Hospital Leuven; KU Leuven; University of Washington; University of Washington Seattle; KU Leuven; University of London; University College London; University College London Hospitals NHS Foundation Trust; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; University of British Columbia; British Columbia Cancer Agency; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Inhibiting the androgen receptor (AR) is effective for treatment of advanced prostate cancers because of their AR- dependent luminal epithelial cell identity. Tumors progress during therapy to castration- resistant prostate cancer (CRPC) by restoring AR signaling and maintaining luminal identity or by converting through lineage plasticity to a neuroendocrine (NE) identity or double- negative CRPC (DNPC) lacking luminal or NE identities. Here, we show that DNPC cells express genes defining basa...
• Quantifying the impact of air pollution from coal-fired electricity generation on crop productivity in India AI翻译
  作者：Singh, Kirat; Lobell, David B.; Azevedo, Ines M. L.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Stanford University; Universidade Nova de Lisboa
  摘要：Air pollution from coal electricity generation is a major driver of poor air quality in India and its effects on human health have been extensively studied. Despite considerable evidence that the same pollution also reduces crop productivity, we lack similar quantitative assessments of coal electricity's crop damages. Here, we estimate rice and wheat crop losses from coal generation's nitrogen dioxide (NO2) emissions using a regression model that combines station-level electricity generation a...