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作者：Singh, Vikram Pal; Li, Jingwen; Dawson, Kana; Mitchell, Jude F.; Miller, Cory T.
作者单位：University of California System; University of California San Diego; University of Rochester; University of California System; University of California San Diego
摘要：Our understanding of how vision functions as primates actively navigate the real- world is remarkably sparse. As most data have been limited to chaired and typically head- restrained animals, the synergistic interactions of different motor actions/plans inherent to active sensing-e.g., eyes, head, posture, movement, etc.-on visual perception are largely unknown. To address this considerable gap in knowledge, we developed an innovative wireless head- mounted eye- tracking system that performs C...
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作者：Huang, Zijue; Ghosh, Kingshuk; Stull, Frederick; Horowitz, Scott
作者单位：University of Denver; University of Denver; University of Denver; Western Michigan University
摘要：Many proteins have slow folding times in vitro that are physiologically untenable. To combat this challenge, ATP- dependent chaperonins are thought to possess the unique ability to catalyze protein folding. Performing quantitative model selection using protein folding and unfolding data, we here show that short nucleic acids containing G- quadruplex (G4) structure can also catalyze protein folding. Performing the experiments as a function of temperature demonstrates that the G4 reshapes the un...
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作者：Maher, Christina; Tortolero, Lea; Jun, Soyeon; Cummins, Daniel D.; Saad, Adam; Young, James; Martinez, Lizbeth Nunez; Schulman, Zachary; Marcuse, Lara; Waters, Allison; Mayberg, Helen S.; Davidson, Richard J.; Panov, Fedor; Saez, Ignacio
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
摘要：Meditation is an accessible mental practice associated with emotional regulation and well- being. Loving- kindness meditation (LKM), a specific subtype of meditative prac-tice, involves focusing one's attention on thoughts of well- being for oneself and others. Meditation has been proven to be beneficial in a variety of settings, including therapeutic applications, but the neural activity underlying meditative practices and their positive effects are not well understood. It has been difficult ...
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作者：Biertumpfel, Christian; Yamada, Yurika; Vasquez-Montes, Victor; Truong, Thien Van; Cada, A. King; Mizuno, Naoko
作者单位：National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS)
摘要：Focal adhesions (FAs) are large intracellular macromolecular assemblies that play a critical role in cell polarization and migration. Talin serves as a direct connection between integrin receptor and actomyosin cytoskeleton within FAs. Talin contains three actin- binding sites (ABS1-3) that engage discreetly during the development of FAs, thus acting as a critical player in FA initiation and maturation. However, the molecular basis of the ABS-F-actin interactions remains unknown. Here, we expl...
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作者：Cassioli, Chiara; Capitani, Nagaja; Staton, Claire C.; Schirra, Claudia; Finetti, Francesca; Onnis, Anna; Alawar, Nadia; Tu, Szu - Min; Lopresti, Ludovica; Tatangelo, Vanessa; Tangredi, Carmela; Valvo, Salvatore; Chang, Hsin - Fang; Miccoli, Annachiara; Compeer, Ewoud B.; Nicholls, Jemma; Blazar, Bruce R.; Marotta, Giuseppe; Wood, Matthew J. A.; Trentin, Livio; Patrussi, Laura; Dustin, Michael L.; Becherer, Ute; Baldari, Cosima T.
作者单位：University of Siena; University of Oxford; Kennedy Institute for Rheumatology; University of Oxford; Universitatsklinikum des Saarlandes; University of Minnesota System; University of Minnesota Twin Cities; University of Siena; University Hospital of Siena; University of Padua
摘要：Cytotoxic attack particles released by CTLs and NK cells include diverse phospholipid membrane and glycoprotein encapsulated entities that contribute to target cell killing. Supramolecular attack particles (SMAPs) are one type of particle characterized by a cytotoxic core enriched in granzymes and perforin surrounded by a proteinaceous shell including thrombospondin (TSP)-1. TSP-4 was also detected in bulk analysis of SMAPs released by CTLs; however, it has not been investigated whether TSP-4 ...
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作者：Knight, David Jonathan; Zhang, Baobao
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作者：Wu, Lilin; Liu, Yongqin; Shi, Wenqing; Chang, Tianyi; Liu, Pengfei; Liu, Keshao; He, Yong; Li, Zhaorong; Shi, Mang; Jiao, Nianzhi; Lang, Andrew S.; Dong, Xiyang; Zheng, Qiang
作者单位：Xiamen University; Xiamen University; Xiamen University; Lanzhou University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Tibetan Plateau Research, CAS; Center for Excellence in Tibetan Plateau Earth Sciences (CETES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Alibaba Group; Sun Yat Sen University; Memorial University Newfoundland; Ministry of Natural Resources of the People's Republic of China; Third Institute of Oceanography, Ministry of Natural Resources
摘要：Alpine lakes, characterized by isolation, low temperatures, oligotrophic conditions, and intense ultraviolet radiation, remain a poorly explored ecosystem for RNA viruses. Here, we present the first comprehensive metatranscriptomic study of RNA viruses in Lake Nam Co, a high- altitude alkaline saline lake on the Tibetan Plateau. Using a combination of sequence- and structure- based homology searches, we identified 742 RNA virus species, including 383 novel genus- level groups and 84 novel fami...
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作者：Savinov, Andrew; Swanson, Sebastian; Keating, Amy E.; Li, Gene - Wei
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Novo Nordisk
摘要：Peptides can bind to specific sites on larger proteins and thereby function as inhibitors and regulatory elements. Peptide fragments of larger proteins are particularly attractive for achieving these functions due to their inherent potential to form native- like binding interactions. Recently developed experimental approaches allow for high- throughput measurement of protein fragment inhibitory activity in living cells. However, it has thus far not been possible to predict de novo which of the...
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作者：Schrom, Edward C.; Mccaffrey, Erin F.; Sreejithkumar, Vivek; Radtke, Andrea J.; Ichise, Hiroshi; Mejias, Armando Arroyo-; Speranza, Emily; Arakkal, Leanne; Thakur, Nishant; Grant, Spencer; Germain, Ronald N.
作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Cleveland Clinic Foundation; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
摘要：Spatial patterns of cells and other biological elements drive physiologic and pathologic processes within tissues. While many imaging and transcriptomic methods document tissue organization, discerning these patterns is challenging, especially when they involve multiple elements in complex arrangements. To address this challenge, we present Spatial Patterning Analysis of Cellular Ensembles (SPACE), an R package for analysis of high- plex spatial data. SPACE is compatible with any data collecti...
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作者：Aubrun, Cecilia; Morel, Rudy; Benzaquen, Michael; Bouchaud, Jean-Philippe
作者单位：Institut Polytechnique de Paris; Ecole Polytechnique; Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Simons Foundation; Flatiron Institute
摘要：We introduce an unsupervised classification framework that leverages a multiscale wavelet representation of time-series and apply it to stock price jumps. In line with previous work, we recover the fact that time-asymmetry of volatility is the major feature that separates exogenous, news-induced jumps from endogenously generated jumps. Local mean-reversion and trend are found to be two additional key features, allowing us to identify new classes of jumps. Using our wavelet-based representation...
