7期

最新文章

• Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis AI翻译
  作者：Ma, Lanjing; Pang, Zhongqiu; Zhang, Haijiao; Yang, Xueling; Zheng, Shaoqin; Chen, Yi; Ding, Weijie; Han, Qing; Zhang, Xi; Cao, Liu; Fei, Teng; Wang, Qiang; Gao, Daming; He, Aina; Hu, Ke-Bang; Li, Xuexin; Sheng, Ren
  作者单位：Northeastern University - China; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Northeastern University - China; China Medical University; South China University of Technology; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Shanghai Jiao Tong University; Jilin University; China Medical University; China Medical University; China Medical University; Karolinska Institutet
  摘要：Clear cell renal cell carcinoma (ccRCC) is the predominant human renal cancer with surging incidence and fatality lately. Hyperactivation of hypoxia- inducible factor (HIF) and mammalian target of rapamycin (mTOR) signaling are the common signatures in ccRCC. Herein, we employed spontaneous ccRCC model to demonstrate the indispensability of an underappreciated Ser/Thr kinase, CDKL3, in the initiation and progression of ccRCC. Ablation of CDKL3 does not affect normal kidney, but abrogates Akt-m...
• Structural characterization of influenza group 1 chimeric hemagglutinins as broad vaccine immunogens AI翻译
  作者：Nguyen, Yen Thi Kim; Zhu, Xueyong; Han, Julianna; Rodriguez, Alesandra J.; Sun, Weina; Yu, Wenli; Palese, Peter; Krammer, Florian; Ward, Andrew B.; Wilson, Ian A.
  作者单位：Scripps Research Institute; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Medical University of Vienna; Scripps Research Institute
  摘要：Chimeric hemagglutinins (cHA) appear to be promising for the design and development of universal influenza vaccines. Influenza A group 1 cHAs, cH5/1, cH8/1, and cH11/1, comprising an H1 stem attached to either an H5, H8, or H11 globular head, have been used sequentially as vaccine immunogens in human clinical trials and induced high levels of broadly protective antibodies. Using X- ray crystallography and negative- stain electron microscopy, we determined structures of cH5/1, cH8/1, and cH11/1...
• Geometric modeling of knitted fabrics AI翻译
  作者：Niu, Lauren; Dion, Genevieve; Kamien, Randall D.
  作者单位：Drexel University; University of Pennsylvania
  摘要：It is undeniable that, by any metric, geometry plays a central role in our understanding of the physical world. From celestial mechanics (1) to soap bubbles (2) and from optics (3) to gravity (4), the rigor of geometric logic intoxicates our thinking. Indeed, because of their intrinsic elegance and potential application, tools have been developed to make materials that assemble into a targeted topography. Whether it be through the techniques of origami (5-7), thermal activation of local materi...
• Debiasing job ads by replacing masculine language increases gender diversity of applicant pools AI翻译
  作者：He, Joyce C.; Kang, Sonia K.
  作者单位：University of California System; University of California Los Angeles; University of Toronto; University Toronto Mississauga
  摘要：Job advertisements for jobs in male- dominated fields tend to contain more masculine language, and a commonly proposed intervention to increase gender diversity in applicant pools is to remove this language. In our research, we offer predictions about the broader impact of such interventions on individuals who may not fit with traditional masculine identity. Across four multimethod studies (N = 37,920) spanning both field and lab settings, we demonstrate that a gender debiasing intervention th...
• Identification of FSH- regulated and estrous stage-specific transcriptional networks in mouse ovaries AI翻译
  作者：Walters, Kathryn; Baldwin, Amber; Liu, Zhenghui; Larsen, Mark; Mukherjee, Neelanjan; Kumar, T. Rajendra
  作者单位：University of Colorado System; University of Colorado Anschutz; University of Colorado System; University of Colorado Anschutz; University of Colorado System; University of Colorado Anschutz
  摘要：Follicle- stimulating hormone (FSH) acts by binding to FSHRs expressed on ovarian granulosa cells and produces estradiol. FSH is essential for female fertility because mice lacking FSH (Fshb KO) are anestrous and infertile. Although several in vitro cell culture and ex vivo approaches combined with pharmacological hormone treatment were used to identify FSH- regulated genes, how FSH orchestrates ovarian gene net-works in vivo has not been investigated. Whether FSH- regulated genes display estr...
• Receptor clustering tunes and sharpens the selectivity of multivalent binding AI翻译
  作者：Xie, Zhaoping; Angioletti-Uberti, Stefano; Dobnikar, Jure; Frenkel, Daan; Curk, Tine
  作者单位：Johns Hopkins University; Johns Hopkins Medicine; Imperial College London; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Cambridge; Johns Hopkins University
  摘要：The immune system exploits a wide range of strategies to combine sensitivity with selectivity for optimal response. We propose a generic physical mechanism that allows tuning the location and steepness of the response threshold of cellular processes activated by multivalent binding. The mechanism is based on the possibility to modulate the attraction between membrane receptors. We use theory and simulations to show how tuning interreceptor attraction can enhance or suppress the binding of mult...
• Mapping of the full polarization switching pathways for HfO2 and its implications AI翻译
  作者：Hu, Qi; Lv, Shuning; Tsai, Hsiaoyi; Xue, Yufeng; Jing, Xixiang; Lin, Fanrong; Tong, Chuanjia; Cao, Tengfei; Teobaldi, Gilberto; Liu, Li - Min
  作者单位：Beihang University; Beihang University; Northwestern Polytechnical University; Nanjing University of Aeronautics & Astronautics; Nanjing University of Aeronautics & Astronautics; Central South University; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory
  摘要：The discovery of ferroelectric phases in HfO2 offers insights into ferroelectricity. Its unique fluorite structure and complex polarization switching pathways exhibit distinct characteristics, challenging conventional analysis methods. Combining group theory and first- principles calculations, we identify numerous unconventional electric polarization switching pathways in HfO2 with energy barriers of 0.32 to 0.57 eV as a function of the different shift in the suboxygen lattices. In total, we i...
• To enhance sustainable development goal research, open up commercial satellite image archives AI翻译
  作者：Rufin, Philippe; Meyfroidt, Patrick; Akinyemi, Felicia O.; Estes, Lyndon; Ibrahim, Esther Shupel; Jain, Meha; Kerner, Hannah; Lisboa, Sa Nogueira; Lobell, David; Nakalembe, Catherine; Persello, Claudio; Picoli, Michelle C. A.; Ribeiro, Natasha; Sitoe, Almeida Alberto; Waha, Katharina; Wang, Sherrie
  作者单位：Universite Catholique Louvain; Humboldt University of Berlin; Fonds de la Recherche Scientifique - FNRS; Karlstad University; University of Bern; Clark University; Leibniz Association; Leibniz Zentrum fur Agrarlandschaftsforschung (ZALF); University of Michigan System; University of Michigan; Arizona State University; Arizona State University-Tempe; Eduardo Mondlane University; Stanford University; Stanford University; University System of Maryland; University of Maryland College Park; University of Twente; Food & Agriculture Organization of the United Nations (FAO); University of Augsburg; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
• Osteocyte connexin hemichannels and prostaglandin E2 release dictate bone marrow mesenchymal stromal cell commitment AI翻译
  作者：Zhang, Jingruo; Acosta, Francisca M.; Wang, Xuewei; Zhao, Dezhi; Zhang, Lidan; Hua, Rui; Guo, Qianjin; Zhong, Leilei; Qin, Ling; Riquelme, Manuel A.; Jiang, Jean X.
  作者单位：University of Texas System; University of Texas at San Antonio; University of Pennsylvania; Pennsylvania Medicine
  摘要：Bone is a dynamic organ constantly undergoing remodeling with both bone formation and resorption. Bone formation is mediated by osteoblasts originating from the differentiation of bone marrow (BM) mesenchymal stem and progenitor cells (BM- MSPCs). However, how bone cells communicate with BM-MSPCs to coordinate bone formation remains largely elusive. Here, we unveil a key role of osteocyte connexin 43 (Cx43) hemichannels in regulating the lineage commitment of BM- MSPCs. Two transgenic mouse mo...
• Photoreceptor- induced LHL4 protects the photosystem II monomer in Chlamydomonas reinhardtii AI翻译
  作者：Dannay, Marie; Bertin, Chloe; Cavallari, Eva; Albanese, Pascal; Tolleter, Dimitri; Giustini, Cecile; Menneteau, Mathilde; Brugiere, Sabine; Coute, Yohann; Finazzi, Giovanni; Demarsy, Emilie; Ulm, Roman; Allorent, Guillaume
  作者单位：Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); CEA; INRAE; Universite Grenoble Alpes (UGA); University of Geneva; Institut National de la Sante et de la Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes; Centre National de la Recherche Scientifique (CNRS); CEA; Universite Grenoble Alpes (UGA); University of Geneva; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); UNICANCER; Gustave Roussy
  摘要：Photosynthesis, the fundamental process using light energy to convert carbon dioxide to organic matter, is vital for life on Earth. It relies on capturing light through light- harvesting complexes (LHC) in photosystem I (PSI) and PSII and on the conver-sion of light energy into chemical energy. Composition and organization of PSI and PSII core complexes are well conserved across evolution. PSII is particularly sensitive to pho-todamage but benefits from a large diversity of photoprotective mec...