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最新文章

• Clinical evaluation of patterned dried plasma spot cards to support quantification of HIV viral load and reflexive genotyping AI翻译
  作者：Morbioli, Giorgio Gianini; Baillargeon, Keith R.; Kalimashe, Monalisa N.; Kana, Vibha; Zwane, Hloniphile; van der Walt, Cheri; Tierney, Allison J.; Mora, Andrea C.; Goosen, Mark; Jagaroo, Rivashni; Brooks, Jessica C.; Hunt, Gillian; Jordan, Michael R.; Tang, Alice; Mace, Charles R.
  作者单位：Tufts University; National Institute for Communicable Diseases (NICD); Tufts University; Massachusetts Department of Public Health; Tufts University
  摘要：Quantifying viral load, a key indicator required to achieve control and elimination of the HIV epidemic, requires cell- free plasma or serum to ensure measurements are not biased by proviral DNA contained in infected CD4 T lymphocytes. Plasma separation cards (PSC) collect and preserve a dried specimen, which makes them practical solutions for decentralized sample collection and transport in limited- resource settings. However, physiological variations in hematocrit levels can introduce signif...
• Spatial profiling of the interplay between cell type- and vision- dependent transcriptomic programs in the visual cortex AI翻译
  作者：Xie, Fangming; Jain, Saumya; Xu, Runzhe; Butrus, Salwan; Tan, Zhiqun; Xu, Xiangmin; Shekhar, Karthik; Zipursky, S. Lawrence
  作者单位：University of California System; University of California Los Angeles; David Geffen School of Medicine at UCLA; University of California Los Angeles Medical Center; University System of Georgia; Georgia Institute of Technology; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Irvine; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：How early sensory experience during critical periods of postnatal life affects the organization of the mammalian neocortex at the resolution of neuronal cell types is poorly understood. We previously reported that the functional and molecular profiles of layer 2/3 (L2/3) cell types in the primary visual cortex (V1) are vision- dependent [S. Cheng et al., Cell 185, 311-327.e24 (2022)]. Here, we characterize the spatial organization of L2/3 cell types with and without visual experience. Spatial ...
• Bacterial species with different nanocolony morphologies have distinct flow-dependent colonization behaviors AI翻译
  作者：Hallinen, Kelsey M.; Bodine, Steven P.; Stone, Howard A.; Muir, Tom W.; Wingreen, Ned S.; Gitai, Zemer
  作者单位：Princeton University; Princeton University; Princeton University; Princeton University; Princeton University
  摘要：Fluid flows are dominant features of many bacterial environments, and flow can often impact bacterial behaviors in unexpected ways. For example, the most common type of cardiovascular infection is heart valve colonization by gram- positive bacteria like Staphylococcus aureus and Enterococcus faecalis (endocarditis). This behavior is counter-intuitive because heart valves experience high shear rates that would naively be expected to reduce colonization. To determine whether these bacteria prefe...
• Variable-strength nonlocal measurements reveal quantum violations of classical counting principles AI翻译
  作者：Lupu-Gladstein, Noah; Pang, Ou Teen Arthur; Ferretti, Hugo; Tham, Weng-Kian; Steinberg, Aephraim M.; Bonsma-Fisher, Kent; Brodutch, Aharon
  作者单位：University of Toronto; University of Toronto; Canadian Institute for Advanced Research (CIFAR); National Research Council Canada
  摘要：We implement a variant of the quantum pigeonhole paradox thought experiment to study whether classical counting principles survive in the quantum domain. We observe strong measurements significantly violate the pigeonhole principle (that among three pigeons in two holes, at least one pair must be in the same hole) and the sum rule (that the number of pigeon pairs in the same hole is the sum of the number of pairs across each of the holes) in an ensemble that is pre- and postselected into parti...
• Engineered immunological niche directs therapeutic development in models of progressive multiple sclerosis AI翻译
  作者：Rad, Laila M.; Hughes, Kevin R.; Wheeler, Sydney N.; Decker, Joseph T.; Orbach, Sophia M.; Galvan, Angelica; Thornhill, Jasmine; Griffin, Kate, V; Turkistani, Hamza; Urie, Russell R.; Irani, David N.; Shea, Lonnie D.; Morris, Aaron H.
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Primary progressive multiple sclerosis (MS) is a demyelinating autoimmune disease with only a single class of FDA- approved treatment, B cell depletion. Novel treatments could emerge from a deeper understanding of the interplay between multiple cell types within diseased tissue throughout progression. We initially describe an engineered biomaterial-based immunological niche (IN) as a surrogate for diseased tissue to investigate immune cell function and phenotype dynamics throughout a chronic p...
• Automated determination of transport and depositional environments in sand and sandstones ( vol 121 , e2407655121, 2024) AI翻译
  作者：Hasson, Michael; Marvin, M. Colin; Lapotre, Mathieu G. A.
• Turbulent mixing controls fixation of growing antagonisticpopulations AI翻译
  作者：Bauermann, Jonathan; Benzi, Roberto; Nelson, David R.; Shankar, Suraj; Toschi, Federico
  作者单位：Harvard University; North University of China; University of Rome Tor Vergata; University of Rome Tor Vergata; University of Michigan System; University of Michigan; Eindhoven University of Technology; Consiglio Nazionale delle Ricerche (CNR)
  摘要：Unlike coffee and cream that homogenize when stirred, growing micro-organisms(e.g., bacteria, baker's yeast) can actively kill each other and avoid mixing. How dosuch antagonistic interactions impact the growth and survival of competing strains,while being spatially advected by turbulent flows? By using numerical simulations of acontinuum model, we study the dynamics of two antagonistic strains that are dispersedby incompressible turbulent flows in two spatial dimensions. A key parameter is th...
• Interrogating nucleotide sequences with AI to understand codon usage patterns AI翻译
  作者：Elazar, Assaf; Mathew, Steve; Babu, M. Madan
  作者单位：St Jude Children's Research Hospital; Vellore Institute of Technology (VIT); VIT Vellore
• A deep learning-enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life AI翻译
  作者：Tang, Chenyu; Yi, Wentian; Xu, Muzi; Jin, Yuxuan; Zhang, Zibo; Chen, Xuhang; Liao, Caizhi; Kang, Mengtian; Gao, Shuo; Smielewski, Peter; Occhipinti, Luigi G.
  作者单位：University of Cambridge; University of Cambridge; University of Cambridge; Capital Medical University; Beihang University
  摘要：In wearable smart systems, continuous monitoring and accurate classification of dif-ferent sleep- related conditions are critical for enhancing sleep quality and preventing sleep- related chronic conditions. However, the requirements for device-skin coupling quality in electrophysiological sleep monitoring systems hinder the comfort and reli-ability of night wearing. Here, we report a washable, skin- compatible smart garment sleep monitoring system that captures local skin strain signals under...
• Mycorrhiza increases plant diversity and soil carbon storage in grasslands AI翻译
  作者：Zhang, Entao; Wang, Yang; Crowther, Thomas W.; Sun, Weicheng; Chen, Shiping; Zhou, Daowei; Shangguan, Zhouping; Huang, Jianhui; He, Jin - Sheng; Wang, Yanfen; Sheng, Jiandong; Tang, Lisong; Li, Xinrong; Dong, Ming; Wu, Yan; Hu, Shuijin; Bai, Yongfei; Yu, Guirui
  作者单位：Chinese Academy of Sciences; Institute of Botany, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Swiss Federal Institutes of Technology Domain; ETH Zurich; Chinese Academy of Sciences; Northeast Institute of Geography & Agroecology, CAS; Northwest A&F University - China; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Lanzhou University; Lanzhou University; Peking University; Xinjiang Agricultural University; Chinese Academy of Sciences; Xinjiang Institute of Ecology & Geography, CAS; Chinese Academy of Sciences; Northwest Institute of Eco-Environment & Resources, CAS; Hangzhou Normal University; Chinese Academy of Sciences; Institute of Optics & Electronics, CAS; Chengdu Institute of Biology, CAS; North Carolina State University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Geographic Sciences & Natural Resources Research, CAS
  摘要：Experimental studies have shown that symbiotic relationships between arbuscular mycorrhizal (AM) fungi and host plants can regulate soil organic carbon (SOC) storage. Although the impacts of mycorrhiza are highly context- dependent, it remains unclear how these effects vary across broad spatial scales. Based on data from 2296 field sites across grassland ecosystems of China, here we show that mycorrhizal fungi symbiosis enhances SOC storage in the topsoil and subsoil through increasing plant d...