Gene duplication captures morph- specific promoter usage in the evolution of aphid wing dimorphisms

• 成果类型: Article
• 署名作者: Ziabari, Omid Saleh; Liu, Fangzhou; Deem, Kevin D.; Liu, Xiaomi; Kholwadwala, Akhil; Brisson, Jennifer A.
• 署名单位: University of Rochester; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-15308
• DOI: 10.1073/pnas.2420893122
• 发表日期: 2025-02-25
• 关键词: pea aphid; evo-devo; sequence; divergence; TREE

摘要

Understanding how morphology evolves requires identifying the types of mutations that contribute to changes in development. We integrated comparative genomics and transcriptomics to reconstruct the evolution and regulation of follistatin paralogs in relation to the evolution of aphid winged and wingless morphs. We find that different pea aphid follistatin duplicates play an essential molecular role in both the male and female wing dimorphisms, linking the genetic and environmental control of morph determination in each sex, respectively. We also find that an ancestral follistatin gene likely had multiple promoters and that the follistatin duplicates that evolved wingless- specific expression retained only the ancestral wingless- specific promoter. Our work provides a roadmap for how alternative promoter usage and subsequent gene duplication can enable the evolution of animal form.