12期

最新文章

• The origin of sulfur in Canary Island magmas and its implications for Earth's deep sulfur cycle AI翻译
  作者：Taracsak, Zoltan; Hartley, Margaret E.; Burgess, Ray; Edmonds, Marie; Longpre, Marc-Antoine; Monteleone, Brian D.; Tartese, Romain; Turchyn, Alexandra, V
  作者单位：University of Cambridge; University of Manchester; City University of New York (CUNY) System; Queens College NY (CUNY); City University of New York (CUNY) System; Woods Hole Oceanographic Institution
  摘要：The global sulfur cycle plays a critical role in the redox evolution of Earth's surface and upper mantle, yet the distribution and origin of sulfur in the mantle remains largely unconstrained. El Hierro is a volcanic island in the Canary archipelago that is fed by sulfur-rich magmas. To constrain the origin of sulfur in these melts, we combine in situ sulfur isotope analyses with regression modeling. We calculate that undegassed El melts is 0.3%o to 1%o higher than magmas erupting at mid-ocean...
• Predicting nature- based coastal protection by mangroves under extreme waves AI翻译
  作者：Hu, Zhan; Temmerman, Stijn; Zhu, Qin; Wang, Xinran; Wu, Jinwei; Xu, Tianping; Schoutens, Ken; Suzuki, Tomohiro; Yang, Zhifeng; Bouma, Tjeerd J.
  作者单位：Sun Yat Sen University; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Zhuhai); Sun Yat Sen University; Sun Yat Sen University; Guangdong Provincial Key Laboratory of Marine Resources & Coastal Engineering; University of Antwerp; Southern Marine Science & Engineering Guangdong Laboratory; Southern Marine Science & Engineering Guangdong Laboratory (Guangzhou); KU Leuven; Guangdong University of Technology; Utrecht University; Royal Netherlands Institute for Sea Research (NIOZ); Utrecht University
  摘要：Forested wetlands such as mangroves are considered highly valuable for nature- based mitigation of coastal flooding. However, their wave attenuation capacity during extreme storms, when risks are highest, is rarely measured and remains challenging to predict. Here, we compile a unique dataset on the largest incident wave heights (0.39 to 1.44 m) ever recorded in forested wetlands, including our own measurements and literature data. Our analysis reveals that forested wetlands can significantly ...
• Absence of water clusters in visible light interactions with the air-water interface AI翻译
  作者：Ahmed, Musahid; Lu, Wenchao
  作者单位：United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
• Flycodes enable simultaneous preclinical analysis for dozens of antibodies in single cassette-dosed mice AI翻译
  作者：Walter, Justin D.; Beffinger, Michal; Egloff, Pascal; Zimmermann, Iwan; Hurlimann, Lea M.; Ackle, Fabian; Seifert, Matthias; Kobold, Sebastian; vom Berg, Johannes; Seeger, Markus A.
  作者单位：University of Zurich; University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ)
  摘要：Protein therapeutics such as antibodies require in- depth in vivo characterization during development and consequently account for a large proportion of laboratory animal consumption in the pharmaceutical industry. Currently, antibody candidates are exhaustively tested one- by- one in animal models to determine pharmacokinetic and pharmacodynamic (PK/PD) profiles. The simultaneous analysis of antibody mixtures in single animals, called cassette- dosing, could in principle overcome this bottlen...
• Pulsatile flow induces chromatin interaction with lamin-associated proteins to enrich H3K9 methylation in endothelial cells AI翻译
  作者：Chen, Li- Jing; Li, Julie Yi- Shuan; Nguyen, Phu; Norwich, Gerard; Wang, Yingxiao; Teng, Dayu; Shiu, Yan- Ting; Shyy, John Y. J.; Chien, Shu
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; University of Southern California; Utah System of Higher Education; University of Utah; US Department of Veterans Affairs; Veterans Health Administration (VHA); Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; University of California System; University of California San Diego
  摘要：Endothelial cells (ECs) are constantly exposed to hemodynamic forces, which play a crucial role in regulating EC functions. Pulsatile laminar shear stress (PS), representing atheroprotective flow, maintains the anti-inflammation and homeostatic phenotype of ECs, but the comprehensive mechanism underlying the PS-repression of inflammatory genes remains to be determined. In this study, we investigated the role of chromatin organization in mediating the effects of PS on inflammatory gene expressi...
• Reinforcement learning-based adaptive strategies for climate change adaptation: An application for coastal flood risk management AI翻译
  作者：Feng, Kairui; Lin, Ning; Kopp, Robert E.; Xian, Siyuan; Oppenheimer, Michael
  作者单位：Tongji University; Princeton University; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Princeton University; Princeton University; Princeton University
  摘要：Conventional computational models of climate adaptation frameworks inadequately consider decision-makers' capacity to learn, update, and improve decisions. Here, we investigate the potential of reinforcement learning (RL), a machine learning technique that efficaciously acquires knowledge from the environment and systematically optimizes dynamic decisions, in modeling and informing adaptive climate decision-making. We consider coastal flood risk mitigations for Manhattan, New York City, USA (N...
• The Mediator subunit OsMED23 associates with the histone demethylase OsJMJ703 and the transcription factor OsWOX3A to control grain size and yield in rice AI翻译
  作者：Huang, Luojiang; Fang, Na; Zhang, Limin; Xu, Ran; Zhang, Baolan; Duan, Penggen; Li, Guansong; Luo, Yuehua; Li, Yunhai
  作者单位：Hainan University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Inner Mongolia University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Seed size is one of the important yield traits, and size control is also a fundamental developmental question. The knowledge about the genetic and molecular mechanisms that govern seed size is crucial for improving crop yield. Here, we report that the Mediator subunit OsMED23 associates with the histone demethylase OsJMJ703 and the transcription factor OsWOX3A to control grain size and weight in rice. Loss of function of OsMED23 or OsJMJ703 causes narrow and light grains, while overexpression ...
• Hardware-optimal quantum algorithms AI翻译
  作者：Muroya, Stefanie; Chatterjee, Krishnendu; Henzinger, Thomas A.
  作者单位：Institute of Science & Technology - Austria
  摘要：Quantum hardware is inherently fragile and noisy. We find that the accuracy of traditional quantum error correction algorithms can be improved depending on the hardware. Given different hardware specifications, we automatically synthesize hardware-optimal algorithms for parity correction, qubit resetting, and GHZ (Greenberger-Horne-Zeilinger) state preparation. Using stochastic techniques from computer science, our method presents a computational tool to compute exact accuracy guarantees and s...
• Structural elucidation of how ARF small GTPases induce membrane tubulation for vesicle fission AI翻译
  作者：Pang, Xiaoyun; Zhang, Yan; Park, Kunyou; Liao, Zhenyu; Li, Jian; Xu, Jiashu; Hong, Minh-Triet; Yin, Guoliang; Zhang, Tongming; Wang, Yaoyu; Egelman, Edward H.; Fan, Jun; Hsu, Victor W.; Park, Seung-Yeol; Sun, Fei
  作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Pohang University of Science & Technology (POSTECH); Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; City University of Hong Kong; City University of Hong Kong; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Virginia; Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS
  摘要：ADP- Ribosylation Factor (ARF) small GTPases have been found to act in vesicle fission through a direct ability to tubulate membrane. We have pursued cryoelectron microscopy (EM) to reveal at 3.9 & Aring; resolution how ARF6 assembles into a protein lattice on tubulated membrane. Molecular dynamics simulation studies confirm and extend the cryo- EM findings. The ARF6 lattice exhibits features that are distinct from those formed by other membrane- bending proteins. We identify protein contacts ...
• A splendid molecular factory: De-and reconstruction of the mammalian respiratory chain AI翻译
  作者：Rimle, Lukas; Phillips, Ben P.; Barra, Isabela M. Codo Costa; Arnold, Noelle; Hennebert, Charlie; Meier, Thomas; von Ballmoos, Christoph
  作者单位：University of Bern; Imperial College London; Swiss Federal Institutes of Technology Domain; ETH Zurich
  摘要：Mitochondrial respiratory complexes I to IV and the F1Fo-ATP synthase (complex V) are large protein assemblies producing the universal cellular energy currency adenosine triphosphate (ATP). Individual complexes have been extensively studied in vitro, but functional co-reconstitution of several mammalian complexes into proteoliposomes, in particular, the combination of a primary pump with the ATP synthase, is less well understood. Here, we present a generic and scalable strategy to purify mamma...