12期

最新文章

• Embryonic reprogramming of the tumor vasculature reveals targets for cancer therapy AI翻译
  作者：Huijbers, Elisabeth J. M.; van Beijnum, Judy R.; van Loon, Karlijn; Griffioen, Christian J.; Volckmann, Richard; Bassez, Ayse; Lambrechts, Diether; Monteiro, Madalena Nunes; Jimenez, Connie R.; Hogendoorn, Pancras C. W.; Koster, Jan; Griffioen, Arjan W.
  作者单位：University of Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam; Vrije Universiteit Amsterdam; Flanders Institute for Biotechnology (VIB); Vrije Universiteit Amsterdam; University of Amsterdam; Leiden University - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC)
  摘要：A sustained blood supply is critical for tumor growth, as it delivers the nutrients and oxygen required for development. Targeting of blood vessel formation via immunotherapies is an area of great importance. Knowing that certain embryonic genes, such as carcinoembryonic antigens (CEA) and oncofetal fibronectin, become reexpressed in malignant transformation, we hypothesized that a similar phenomenon holds true for tumor endothelial cells (TECs) as well. An approach for identification of highl...
• Spiral spin liquid noise AI翻译
  作者：Takahashi, Hiroto; Hsu, Chun-Chih-Chih; Jerzembeck, Fabian; Murphy, Jack; Ward, Jonathan; Enright, Jack D.; Knapp, Jan; Puphal, Pascal; Isobe, Masahiko; Matsumoto, Yosuke; Takagi, Hidenori; Davis, J. C. Seamus; Blundell, Stephen J.
  作者单位：University of Oxford; Max Planck Society; University College Cork; Max Planck Society; Cornell University
  摘要：An emerging concept for identification of different types of spin liquids [C. Broholm et al., Science 367, eaay0668 (2020)] is through the use of spontaneous spin noise [S. Chatterjee, J. F. Rodriguez-Nieva, E. Demler, Phys. Rev. B 99, 104425 (2019)]. Here, we develop spin noise spectroscopy for spin liquid studies by considering Ca10Cr7O28, a material hypothesized to be either a quantum or a spiral spin liquid (SSL). By enhancing techniques introduced for magnetic monopole noise studies [R. D...
• MITD1 is a brain- specific interferon- inducible factor that inhibits flavivirus replication AI翻译
  作者：Zoladek, Jim; Cannac, Marion; Seite, Mael; Davies, Emma; Quellec, Jordan; Barthelemy, Jonathan; Gorna, Kamila; Desgraupes, Sophie; Bribes, Ines; Salinas, Sara; Coulpier, Muriel; Arhel, Nathalie J.; Palmarini, Massimo; Simonin, Yannick; Wilson, Sam J.; Nisole, Sebastien
  作者单位：Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite de Montpellier; Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Glasgow; INRAE; Universite de Montpellier; CIRAD; Agence Nationale de Securite Sanitaire de l'Alimentation, de l'Environnement du Travail (ANSES); Laboratoire de Sante Animale de Maisons-Alfort; INRAE; Ecole Nationale Veterinaire d'Alfort (ENVA); University of Cambridge
  摘要：West Nile virus (WNV) and Usutu virus (USUV) are closely related mosquito- borne neurotropic flaviviruses that share common transmission cycle and can infect humans. However, while human infections by WNV are widespread, infections by USUV are comparatively less frequent, less severe, and currently limited to Africa and Europe. To identify human host factors that contribute to the pathogenic signatures of these two flaviviruses, we carried out an arrayed expression screen of over 1,300 interfe...
• ETV5 reduces androgen receptor expression and induces neural stem-like properties during neuroendocrine prostate cancer development AI翻译
  作者：Lee, Jongeun; Park, Jiho; Hur, Yunjung; Um, Dahun; Choi, Hyung-Seok; Park, Joonyoung; Kim, Yewon; Lee, Jeon-Soo; Choi, Kyuha; Kim, Eunjeong; Park, Young Bin; Choi, Jae-Mun; Kim, Tae-Kyung; Lee, Yoontae
  作者单位：Pohang University of Science & Technology (POSTECH); Kyungpook National University (KNU); Chungnam National University; Korea University; Yonsei University
  摘要：Neuroendocrine prostate cancer (NEPC), an aggressive subtype induced by hormone therapy, lacks effective treatments. This study explored the role of E26 transformation-specific variant 5 (ETV5) in NEPC development. Analysis of multiple prostate cancer datasets revealed that NEPC is characterized by significantly elevated ETV5 expression compared to other subtypes. ETV5 expression increased progressively under hormone therapy through epigenetic modifications. ETV5 induced neural stem-like featu...
• ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis-induced macrophage death AI翻译
  作者：Yang, Ziwei; Zhang, Li; Ottavi, Samantha; Geri, Jacob B.; Perkowski, Andrew; Jiang, Xiuju; Pfau, Daniel; Bryk, Ruslana; Aube, Jeffrey; Zimmerman, Matthew; Dartois, Veronique; Nathan, Carl
  作者单位：Cornell University; Weill Cornell Medicine; Southern University of Science & Technology; University of North Carolina; University of North Carolina Chapel Hill; Cornell University; Weill Cornell Medicine
  摘要：Mycobacterium tuberculosis (Mtb) primarily infects macrophages. In vitro without antibiotics, wild-type Mtb hastens death of the macrophages, but the processes leading to rapid cell death are not well understood. Our earlier work indicated that the death of Mtb-infected mouse macrophages in vitro is markedly exacerbated by induction of interferon-f3 (IFN-f3) [L. Zhang et al.,J. Exp. Med. 18, e20200887 (2021)]. Here, we identified a key downstream response to IFN-f3 in the context of Mtb infect...
• Global phase diagram of D-wave superconductivity in the square-lattice t-J model AI翻译
  作者：Chen, Feng; Haldane, F. D. M.; Sheng, D. N.
  作者单位：California State University System; California State University Northridge; Princeton University
  摘要：The Hubbard and closely related t-J models are exciting platforms for unconventional superconductivity (SC). Through state-of-the-art density matrix renormalization group calculations using the grand canonical ensemble, we address open issues regarding the ground-state phase diagram of the extended t-J model on a square lattice in the parameter regime relevant to cuprate superconductors. On large 8-leg cylinders, we demonstrate that the pure t-J model with only nearest-neighbor hoppings and su...
• ANGPTL3/8 is an atypical unfoldase that regulates intravascular lipolysis by catalyzing unfolding of lipoprotein lipase AI翻译
  作者：Kumari, Anni; Larsen, Sanne W. R.; Bondesen, Signe; Qian, Yuewei; Tian, Hao D.; Walker, Sydney G.; Davies, Brandon S. J.; Remaley, Alan T.; Young, Stephen G.; Konrad, Robert J.; Jorgensen, Thomas J. D.; Ploug, Michael
  作者单位：University of Copenhagen; Copenhagen University Hospital; Rigshospitalet; University of Copenhagen; University of Southern Denmark; Eli Lilly; Lilly Research Laboratories; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of Iowa; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
  摘要：Lipoprotein lipase (LPL) carries out the lipolytic processing of triglyceride-rich lipoproteins (TRL) along the luminal surface of capillaries. LPL activity is regulated by the angiopoietin-like proteins (ANGPTL3, ANGPTL4, ANGPTL8), which control the delivery of TRL-derived lipid nutrients to tissues in a temporal and spatial fashion. This regulation of LPL mediates the partitioning of lipid delivery to adipose tissue and striated muscle according to nutritional status. A complex between ANGPT...
• Agriculture's impact on water-energy balance varies across climates AI翻译
  作者：Zaerpour, Masoud; Hatami, Shadi; Papalexiou, Simon Michael; Pietroniro, Alain; Nazemi, Ali
  作者单位：University of Calgary; Universidade de Sao Paulo; Czech University of Life Sciences Prague; Concordia University - Canada
  摘要：Agriculture is a cornerstone of global food production, accounting for a substantial portion of water withdrawals worldwide. As the world's population grows, so does the demand for water in agriculture, leading to alterations in regional water-energy balances. We present an approach to identify the influence of agriculture on the water-energy balance using empirical data. We explore the departure from the Budyko curve for catchments with agricultural expansion and their associations with chang...
• Molecular design principles for bipolar spindle organization by two opposing motors AI翻译
  作者：Chew, Wei-Xiang; Nedelec, Francois; Surrey, Thomas
  作者单位：Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); University of Cambridge; Pompeu Fabra University; ICREA
  摘要：During cell division in animal cells, a bipolar spindle assembles to segregate the chromosomes. Various motor proteins with different properties are essential for spindle self- organization. The minimal set of components required to organize dynamic microtubules into a bipolar network remains however unknown. Here, we use computer simulations to explore whether two types of microtubule- crosslinking motors with opposite directionality can organize dynamic microtubules into bipolar spindles in ...
• Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement AI翻译
  作者：Zucca, Stefano; Brunori, Gloria; Dunn, Henry A.; Lankford, Colten K.; Sutton, Laurie P.; Flores, Beatriz Algibez; Maza, Nycole A.; Sial, Omar; Crynen, Gogce; Lujan, Rafael; Martemyanov, Kirill A.
  作者单位：State University System of Florida; University of Florida; State University System of Florida; University of Florida; Universidad de Castilla-La Mancha; University of Manitoba; University of Manitoba; Children's Hospital Research Institute of Manitoba; University of Manitoba; Saint Boniface Hospital; University System of Maryland; University of Maryland Baltimore County
  摘要：Opioids trigger structural and functional neural adaptations of the reward circuit that lead to dependence. Synaptic cell adhesion molecules (CAMs) play a pivotal role in circuit organization and present prime candidates for orchestrating remodeling of neural connections in response to drug exposure. However, the contribution of CAMs to opioid-induced rewiring of the reward circuit has not been explored. Here, we used unbiased molecular profiling to identify CAMs in the nucleus accumbens (NAc)...