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作者：Colen, Jonathan; Han, Ming; Zhang, Rui; Redford, Steven A.; Lemma, Linnea M.; Morgan, Link; Ruijgrok, Paul, V; Adkins, Raymond; Bryant, Zev; Dogic, Zvonimir; Gardel, Margaret L.; de Pablo, Juan J.; Vitelli, Vincenzo
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作者：Wang, Lin; Zhang, Haonan; Jia, Qi; Li, Wenyan; Yang, Chenguang; Ma, Lijuan; Li, Ming; Lu, Ying; Zhu, Hongtao; Zhu, Ping
作者单位：Chinese Academy of Sciences; Institute of Biophysics, CAS; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：NuA4 is the only essential acetyltransferase in yeast that can catalyze the acetylation the histones H2A, H2A.Z, and H4, thereby affecting gene transcription. However, the acetylation process of NuA4, such as how NuA4 acetylates H4 and H2A.Z differently, remains largely elusive. Here, using cryoelectron microscopy (cryo-EM) single particle analysis, we present seven cryo-EM structures of piccolo NuA4 (pNuA4) in complex with wild-type H2A.Z or H2A.Z-mutant-containing nucleosomes in the absence ...
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作者：Zhong, Jia-Xin; Ji, Jun; Xia, Xiaoxing; Heo, Hyeonu; Jing, Yun
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; United States Department of Energy (DOE); Lawrence Livermore National Laboratory
摘要：Delivering audible content to a targeted listener without disturbing others is paramount in audio engineering. However, achieving this goal has long been challenging due to the diffraction of low-frequency (long-wavelength) audio waves in linear acoustics. Here, we introduce an approach for creating remote audio spots, dubbed audible enclaves, by harnessing the local nonlinear interaction of two self-bending ultrasonic beams with distinct spectra. The self-bending ultrasonic beams created by a...
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作者：Nishitani, Shoichi; Ao, Kevin; Jalil, Amad; Arias-Soto, Octavio I.; Moudi, Ava; Chen, Feiyang; Biyani, Ankita; Muppirala, Padma N.; Landry, Markita P.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Chan Zuckerberg Initiative (CZI)
摘要：Single-walled carbon nanotubes (SWCNTs) exhibit nonphotobleaching, near-infrared (NIR) fluorescence suitable for bioimaging applications. In particular, SWCNT fluorescence quenching induced by biopolymer dispersants facilitates flexible design of molecular nanosensors, yet challenges remain in analyte selectivity and lack of rational design strategies. A sought-after alternative to haphazard molecular modulation of SWCNT-based fluorescence is to couple the movement of a quencher to the SWCNT s...
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作者：Suzuki, Yuichiro; Amaya, Stephanie; Gonzalez, Paula; Becerril, Daniela; Aquit, Surisadai; Davis, Maya; Hoesel, Madeline; Chou, Elizabeth; Khong, Hesper; Zaia, Kathryn; Park, Heidi S.; Nijhout, H. Frederik; Tjaden, Brian
作者单位：Wellesley College; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Duke University; Wellesley College
摘要：How organisms evolve under extreme environmental changes is a critical question in the face of global climate change. Genetic accommodation is an evolutionary process by which natural selection acts on novel phenotypes generated through repeated encounters with extreme environments. In this study, polyphenic and monophenic strains of the black mutant tobacco hornworm, Manduca sexta, were evolved via genetic accommodation of heat stress-induced phenotypes, and the molecular differences between ...
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作者：Sauciuc, Adina; Whittaker, Jacob; Tadema, Matthijs; Tych, Katarzyna; Guskov, Albert; Maglia, Giovanni
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作者：Deng, Yuhang; Maple, M. Brian
作者单位：University of California System; University of California San Diego
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作者：Xia, Deming; Zeng, Fanqi; Chen, Wanting; Zhao, Hui; Xie, Hong - bin; Chen, Jingwen; Francisco, Joseph S.
作者单位：Dalian University of Technology; University of Pennsylvania; Dalian University of Technology; State Key Laboratory Surfactant Fine Chemistry
摘要：Peptides and proteins, essential components of living organisms, are composed of amino acids linked by peptide bonds. However, the mechanism of peptide bond formation during the prebiotic era remains unclear. In this study, advanced Born-Oppenheimer molecular dynamics (BOMD) simulations were used to investigate the mechanisms and kinetics of peptide bond formation at air-water interfaces using diglycine, the simplest dipeptide, as a model molecule. The results show that peptide bonds can be ra...
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作者：Xu, Liang; Chen, Ye; Dutra-Clarke, Marina; Mayakonda, Anand; Hazawa, Masaharu; Savinoff, Steve E.; Doan, Ngan; Said, Jonathan W.; Yong, William H.; Watkins, Ashley; Yang, Henry; Ding, Ling-Wen; Tyner, Jeffrey W.; Ching, Jianhong; Kovalik, Jean- Paul; Madan, Vikas; Chan, Shing-Leng; Muschen, Markus; Breunig, Joshua J.; Lin, De-Chen; Koeffler, H. Phillip
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作者：Hall, Johanna L.; Yang, Shiun -, Jr.; Limmer, David T.; Fleming, Graham R.; Rossky, Peter J.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Massachusetts Institute of Technology (MIT)
摘要：Photosystem II (PSII) can achieve near-unity quantum efficiency of light harvesting in ideal conditions and can dissipate excess light energy as heat to prevent the formation of reactive oxygen species (ROS) under light stress. Understanding how this pigment-protein complex accomplishes these opposing goals is a topic of great interest that has so far been explored primarily through the lens of the system energetics. Despite PSII's known flat energy landscape, a thorough consideration of the e...
