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作者：Yang, Hang; Wu, Guowei; Li, Yaoxin; Xu, Xiaoyu; Cong, Jing; Xu, Haoshu; Ma, Yiyao; Li, Yang; Chen, Runsen; Pines, Adam; Xu, Ting; Sydnor, Valerie J.; Satterthwaite, Theodore D.; Cui, Zaixu
作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Institute for Brain Research, Beijing; Chinese Academy of Sciences; Institute of Psychology, CAS; University of Michigan System; University of Michigan; Beijing Normal University; Peking University; Tsinghua University; Stanford University; Stanford Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine
摘要：The human cerebral cortex exhibits intricate interareal functional synchronization at the macroscale, with substantial individual variability in these functional connections. However, the spatial organization of functional connectivity (FC) variability across the human connectome edges and its significance in cognitive development remain unclear. Here, we identified a connectional axis in the edge-level FC variability. The variability declined continuously along this axis from within-network t...
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作者：Hong, Yuan; Peng, Xiangjun; Yu, Haomin; Jafari, Mohammad; Shakiba, Delaram; Huang, Yuxuan; Qu, Chengqing; Melika, Ermia E.; Tawadros, Andrew K.; Mujahid, Aliza; Huang, Yin-Yuan; Sandler, Jacob A.; Pryse, Kenneth M.; Sacks, Justin M.; Elson, Elliot L.; Genin, Guy M.; Alisafaei, Farid
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL); Johns Hopkins University; Johns Hopkins Medicine; New Jersey Institute of Technology; Washington University (WUSTL); Washington University (WUSTL)
摘要：Mechanical stretch can activate long- lived changes in fibroblasts, increasing their contractility and initiating phenotypic transformations. This activation, critical to wound healing and procedures such as skin grafting, increases with mechanical stimulus for cells cultured in two- dimensional but is highly variable in cells in three- dimensional (3D) tissue. Here, we show that static mechanical stretch of cells in 3D tissues can either increase or decrease fibroblast activation depending up...
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作者：Chen, Chen; Yi, Ruiqin; Igisu, Motoko; Afrin, Rehana; Sithamparam, Mahendran; Chandru, Kuhan; Ueno, Yuichiro; Sun, Linhao; Laurenzi, Tommaso; Eberini, Ivano; Fraccia, Tommaso P.; Wang, Anna; Cleaves, H. James; Jia, Tony Z.
作者单位：Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Japan Agency for Marine-Earth Science & Technology (JAMSTEC); Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia; University of Duisburg Essen; Kanazawa University; University of Milan; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; Howard University
摘要：alpha- hydroxy acids (alpha HAs), simple and prebiotically plausible organic monomers, were likely present in various environments on and off Earth and could have played a role in directing the emergence of the first homochiral living systems. Some alpha HAs, which could have been of varying chirality, can undergo dehydration polymerization into polyesters, which could assemble into membraneless microdroplets upon rehydration; understanding these processes is critical for unraveling how simple...
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作者：Hu, Zhaolong; Baer, Alexander; Hering, Lars; Oliveira, Ivo de Sena; Poulhazan, Alexandre; Browne, Darren C.; Guo, Xue; Perrin, Quentin Moana; Sobota, Radoslaw M.; Hoon, Shawn; Mayer, Georg; Kannan, Srinivasaraghavan; Verma, Chandra S.; Harrington, Matthew J.; Miserez, Ali
作者单位：Nanyang Technological University; McGill University; Universitat Kassel; Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Agency for Science Technology & Research (A*STAR); A*STAR - Institute of Molecular & Cell Biology (IMCB); Agency for Science Technology & Research (A*STAR); A*STAR - Bioinformatics Institute (BII); National University of Singapore; Nanyang Technological University
摘要：The slime of velvet worms (Onychophora) is a protein- based bioadhesive that undergoes rapid, yet reversible transition from a fluid into stiff fibers used for prey capture and defense, but the mechanism by which this phase transition functions is largely unknown. Here, integrating transcriptomic and proteomic approaches with AI- guided structure predictions, we discover a group of evolutionarily conserved leucine- rich repeat (LRR) proteins in velvet worm slime that readily adopt a receptor- ...
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作者：Hall, Johanna L.; Yang, Shiun -, Jr.; Limmer, David T.; Fleming, Graham R.; Rossky, Peter J.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Massachusetts Institute of Technology (MIT)
摘要：Photosystem II (PSII) can achieve near-unity quantum efficiency of light harvesting in ideal conditions and can dissipate excess light energy as heat to prevent the formation of reactive oxygen species (ROS) under light stress. Understanding how this pigment-protein complex accomplishes these opposing goals is a topic of great interest that has so far been explored primarily through the lens of the system energetics. Despite PSII's known flat energy landscape, a thorough consideration of the e...
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作者：Lin, Leiming; Li, Zheng; Ren, Jun; Meng, Ying; Luan, Fubo
作者单位：Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; North University of China
摘要：The co-occurrence of arsenic and uranium in groundwater has been found in many countries, posing a significant challenge to human health. Here, we have demonstrated the efficient simultaneous removal of arsenic and uranyl-carbonate complexes from groundwater using {001}-TiO2. Surprisingly, the presence of U(VI) greatly enhanced the adsorption of As(V) on {001}-TiO2, while As(V) had a negligible impact on U(VI) adsorption. Through in situ ATR-FTIR spectroscopy, we uncovered a mechanism involvin...
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作者：Tian, Zhong; Wang, Kou; Guo, Shuang; Li, Jia - Xu; King-Jones, Kirst; Zhu, Fen; Liu, Wen; Wang, Xiao-Ping
作者单位：Huazhong Agricultural University; Chengdu University of Traditional Chinese Medicine; University of Alberta
摘要：Diapause, a developmental arrest mechanism, helps animals to survive seasonal changes via endocrine regulation. While obligate diapause is genetically programmed, facultative diapause is typically triggered by environmental cues such as photoperiod. In insects, this often leads to reproductive diapause characterized by reduced juvenile hormone (JH) signaling, resulting in ovarian arrest and lipid accumulation. However, the molecular link between photoperiod and hormonal control remains poorly ...
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作者：Mathew, Anand; Kulkarni, Yashashree
作者单位：University of Houston System; University of Houston
摘要：Interaction of electric fields with biological cells is indispensable for many physiological processes. Thermal electrical noise in the cellular environment has long been considered as the minimum threshold for detection of electrical signals by cells. However, there is compelling experimental evidence that the minimum electric field sensed by certain cells and organisms is many orders of magnitude weaker than the thermal electrical noise limit estimated purely under equilibrium considerations...
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作者：LiWang, Andy; Orban, John
作者单位：University of California System; University of California Merced; University of California System; University of California Merced; University System of Maryland; Universities at Shady Grove; University of Maryland Baltimore; University System of Maryland; University of Maryland College Park
摘要：Metamorphic proteins switch reversibly between two differently folded states under a variety of environmental conditions. Their identification and prediction are gaining attention, but the fundamental physicochemical basis for fold switching remains poorly understood. In this Perspective article, we address this problem by surveying the landscape of well-characterized metamorphic proteins and noting that a significant fraction of them display temperature sensitivity. We then make the case that...
