12期

最新文章

• The PBAP chromatin remodeling complex mediates summer diapause via H3K4me3-driven juvenile hormone regulation in Colaphellus bowringi AI翻译
  作者：Tian, Zhong; Wang, Kou; Guo, Shuang; Li, Jia - Xu; King-Jones, Kirst; Zhu, Fen; Liu, Wen; Wang, Xiao-Ping
  作者单位：Huazhong Agricultural University; Chengdu University of Traditional Chinese Medicine; University of Alberta
  摘要：Diapause, a developmental arrest mechanism, helps animals to survive seasonal changes via endocrine regulation. While obligate diapause is genetically programmed, facultative diapause is typically triggered by environmental cues such as photoperiod. In insects, this often leads to reproductive diapause characterized by reduced juvenile hormone (JH) signaling, resulting in ovarian arrest and lipid accumulation. However, the molecular link between photoperiod and hormonal control remains poorly ...
• Active matter as the underpinning agency for extraordinary sensitivity of biological membranes to electric fields AI翻译
  作者：Mathew, Anand; Kulkarni, Yashashree
  作者单位：University of Houston System; University of Houston
  摘要：Interaction of electric fields with biological cells is indispensable for many physiological processes. Thermal electrical noise in the cellular environment has long been considered as the minimum threshold for detection of electrical signals by cells. However, there is compelling experimental evidence that the minimum electric field sensed by certain cells and organisms is many orders of magnitude weaker than the thermal electrical noise limit estimated purely under equilibrium considerations...
• Unveiling the cold reality of metamorphic proteins AI翻译
  作者：LiWang, Andy; Orban, John
  作者单位：University of California System; University of California Merced; University of California System; University of California Merced; University System of Maryland; Universities at Shady Grove; University of Maryland Baltimore; University System of Maryland; University of Maryland College Park
  摘要：Metamorphic proteins switch reversibly between two differently folded states under a variety of environmental conditions. Their identification and prediction are gaining attention, but the fundamental physicochemical basis for fold switching remains poorly understood. In this Perspective article, we address this problem by surveying the landscape of well-characterized metamorphic proteins and noting that a significant fraction of them display temperature sensitivity. We then make the case that...
• Deficiency in platelet 12-lipoxygenase exacerbates inflammation and disease severity during SARS-CoV-2 infection AI翻译
  作者：Andrade, Ana Claudia dos S. P.; Lacasse, Emile; Dubuc, Isabelle; Gudimard, Leslie; Gravel, Annie; Puhm, Florian; Campolina-Silva, Gabriel; Queiroz-Junior, Celso; Allaeys, Isabelle; Prunier, Julien; Wallen, Oumaima Azeggouar; Dumais, Elizabeth; Belleannee, Clemence; Droit, Arnaud; Flamand, Nicolas; Boilard, Eric; Flamand, Louis
  作者单位：Laval University; Laval University; Universidade Federal de Minas Gerais; Laval University; Laval University; Laval University Hospital; Laval University; Laval University; Laval University
  摘要：Platelets, known for maintaining blood balance, also participate in antimicrobial defense. Upon severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, platelets become hyperactivated, releasing molecules such as cytokines, granule contents, and bioactive lipids. The key effector biolipids produced by platelets include 12-hydroxyeicosatetraenoic acid (12-HETE) and 12-hydroxyeicosatrienoic acid (12-HETrE), produced by 12-lipoxygenase (12-LOX), and prostaglandins and thromboxane, ...
• Hair cell apoptosis and deafness in Tmc1 mutations AI翻译
  作者：Beurg, Maryline; Konrad, Dakota Elle; Fettiplace, Robert
  作者单位：University of Wisconsin System; University of Wisconsin Madison
  摘要：Transmembrane channel-like protein 1 (TMC1), a pore-forming component of the mechano-electrical transducer (MET) channel in cochlear outer hair cells, is subject to numerous mutations causing deafness and hair cell death. We studied mice harboring semidominant mutations Tmc1 p.T416K, p.M412K, and p.D569N, which all display functional MET channels at postnatal day (P)6 but become deaf by P21. Early signs of concomitant hair cell apoptosis were assayed in neonatal Tmc1 mutants by labeling with C...
• Nonpathological inflammation drives the development of an avian flight adaptation (vol 120, e2219757120, 2023) AI翻译
  作者：Rashid, Dana J.; Sheheen, Joseph R.; Huey, Tori; Surya, Kevin; Sanders, Jackson B.; Horner, John R.; Voyich, Jovanka; Chapman, Susan C.
• Androgen receptors in corticotropin- releasing hormone neurons mediate the sexual dimorphism in restraint- induced thymic atrophy AI翻译
  作者：Meng, Yutong; Li, Yaning; Gu, Huating; Chen, Ziyao; Cui, Xiaoyang; Wang, Xiaodong
  作者单位：National Institute of Biological Sciences, Beijing; Tsinghua University; Chinese Academy of Sciences; Institute of Biophysics, CAS; Tsinghua University
  摘要：Sexual dimorphism in immune responses is well documented, but the underlying mechanisms remain incompletely understood. Here, we identified a subset of corticotropin-releasing hormone (CRH) neurons that express androgen receptors (ARs) as key mediators of sex differences in restraint-induced immunosuppression. Mechanistically, androgens directly activate AR-positive CRH neurons, enhancing the hypothalamic-pituitary-adrenal axis activation. This results in elevated corticosterone levels in resp...
• Red-light signaling pathway activates desert cyanobacteria to prepare for desiccation tolerance AI翻译
  作者：Xu, Hai-Feng; Dai, Guo-Zheng; Li, Ren-Han; Bai, Yang; Zuo, Ai-Wei; Zhao, Lei; Cui, Shu-Ren; Shang, Jin-Long; Cheng, Chao; Wang, Yu-Jie; Feng, Gui-Fang; Duanmu, Deqiang; Kaplan, Aaron; Qiu, Bao-Sheng
  作者单位：Central China Normal University; Central China Normal University; Huazhong Agricultural University; Hubei Hongshan Laboratory; Hebrew University of Jerusalem
  摘要：Desiccation-tolerant cyanobacteria are able to survive frequent cycles of hydration and dehydration, which are closely linked to diurnal light oscillations. Previous studies have shown that light serves as a crucial anticipatory cue, activating desert cyanobacteria to prepare for desiccation. However, the mechanisms underlying their light-coupled desiccation tolerance remain largely unknown. Here, we demonstrate that red-light-induced photosynthetic genes are positively regulated by a LuxR fam...
• Tumor immune evasion: Systemic immunosuppressive networks beyond the local microenvironment AI翻译
  作者：Yan, Chengsong; Wang, Xiao- Fan
  作者单位：Duke University
• Substrate specificities of two ketosynthases in eukaryotic microalgal and prokaryotic marine bacterial DHA synthases AI翻译
  作者：Ogata, Kaito; Nakama, Riku; Kobayashi, Hiyu; Kawata, Tomoya; Maruyama, Chitose; Tsunoda, Takeshi; Ujihara, Tetsuro; Hamano, Yoshimitsu; Ogasawara, Yasushi; Dairi, Tohru
  作者单位：Hokkaido University; Fukui Prefectural University; Hokkaido University; Kyowa Hakko Bio Co., Ltd.
  摘要：Highly reducing iterative polyketide synthases (HR-iPKSs) are huge enzyme complexes with multiple catalytic domains that biosynthesize polyketides by intrinsically programmed iterative carbon chain extensions and reductions. Unlike most HR-iPKSs, which possess a single ketosynthase (KS) domain for all carbon chain elongations, polyunsaturated fatty acid (PUFA) synthases contain two KS domains. We previously examined the substrate specificities of two KS domains of prokaryotic marine PUFA synth...