14期

最新文章

• Monomers and short oligomers of human RAD52 promote single-strand annealing AI翻译
  作者：Kharlamova, Maria A.; Kushwah, Manish S.; Jachowski, Tobias J.; Subramaniam, Sivaraman; Schiff, Viktor; Stewart, A. Francis; Kukura, Philipp; Schaeffer, Erik
  作者单位：Eberhard Karls University of Tubingen; University of Oxford; Technische Universitat Dresden; University of New South Wales Sydney; Shandong University
  摘要：Genome maintenance and stability rely on the repair of DNA double-strand breaks. Breaks can be repaired via the single-strand-annealing pathway mediated by the protein RAD52. RAD52 oligomerizes to rings that are thought to promote annealing. However, rings have only been observed at micromolar concentrations at which annealing activity is impaired. Thus, it is unclear which oligomeric form is responsible for annealing. We combined single-molecule mass photometry with biochemical assays to dete...
• Reply to Brown et al.: Significant sex differences in accelerated cortical thinning associated with the COVID-19 lockdowns AI翻译
  作者：Corrigan, Neva M.; Rokem, Ariel; Kuhl, Patricia K.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
• Critical dynamics predicts cognitive performance and provides a common framework for heterogeneous mechanisms impacting cognition AI翻译
  作者：Mueller, Paul Manuel; Miron, Gadi; Holtkamp, Martin; Meisel, Christian
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
  摘要：The brain criticality hypothesis postulates that brain dynamics are set at a phase transition where information processing is optimized. Long-range temporal correlations (TCs) characterizing the dissipation of information within a signal have been shown to be a hallmark of brain criticality. However, the experimental link between cognitive performance, criticality, and thus TCs has remained elusive due to limitations in recording length and spatial and temporal resolution. In this study, we in...
• Allosterically switchable network orients β-flap in Clostridioides difficile toxins AI翻译
  作者：Finn, Lauren M.; Cummer, Rebecca; Castagner, Bastien; Keller, Bettina G.
  作者单位：Free University of Berlin; McGill University
  摘要：Allosteric proteins exhibit a functional response upon ligand binding far from the active site. Clostridioides difficile toxins use allosteric binding by the endogenous cofactor myo-inositol hexakisphosphate to orchestrate self-cleavage from within the target cell. This binding event induces a conformational shift, primarily effecting a lever-like /3-flap region, with two known orientations. We uncovered a mechanism for this allosteric transition using extensive atomistic molecular dynamics si...
• The TRPV3 channel is a mediator of zinc influx and homeostasis in murine oocytes AI翻译
  作者：Lopes, Emily M.; Akizawa, Hiroki; Koc, Oguz C.; Soto-Moreno, Edgar; Gupta, Neha; Ardestani, Goli; Balboula, Ahmed Z.; Carvacho, Ingrid; Fissore, Rafael A.
  作者单位：University of Massachusetts System; University of Massachusetts Amherst; University of Massachusetts System; University of Massachusetts Amherst; University of Pennsylvania; University of Missouri System; University of Missouri Columbia; Universidad Catolica del Maule
  摘要：Zinc (Zn2+) homeostasis is essential for gametogenesis and reproduction, and its deficiency causes infertility. Oocytes contain higher Zn2+ levels than somatic cells, and Zn2+ concentrations in oocytes are far higher than those of other transition metals and increase even more during maturation in preparation for fertilization. Remarkably, it is unknown what transporter(s) or channel(s) mediate Zn2+ influx in oocytes and whether they are expressed uniformly throughout folliculogenesis. Here, w...
• A conserved ARF-DNA interface underlies auxin- triggered transcriptional response AI翻译
  作者：Rienstra, Juriaan; Carrasco, Vanessa Polet Carrillo -; de Roij, Martijn; Garcia, Jorge; Weijers, Dolf
  作者单位：Wageningen University & Research
  摘要：Auxin Response Factor (ARF) plant transcription factors are the key effectors in auxin signaling. Their DNA-Binding Domain (DBD) contains a B3 domain that allows base-specific interactions with Auxin Response Elements (AuxREs) in DNA target sites. Land plants encode three phylogenetically distinct ARF classes: the closely related Aand B-classes have overlapping DNA binding properties, contrasting with the different DNA-binding properties of the divergent C-class ARFs. ARF DNA-binding divergenc...
• Academic achievement helps coordination on mutually advantageous outcomes AI翻译
  作者：Brocas, Isabelle; Carrillo, Juan D.
  作者单位：University of Southern California; Centre for Economic Policy Research - UK
  摘要：This study examines the relationship between academic achievement and strategic ability to coordinate among middle school students. We designed an experimental framework using repeated asymmetric Battle of the Sexes and Hawk-Dove games, to explore how cognitive and social skills related to academic success influence behavior. A total of 132 students participated, divided into groups of high and low academic achievers based on their performance at school. Our results show that, on average, high...
• Transparency by Chinese cities reduces pollution violations and improves air quality AI翻译
  作者：Liu, Mengdi; Buntaine, Mark T.; Anderson, Sarah E.; Zhang, Bing
  作者单位：University of International Business & Economics; University of California System; University of California Santa Barbara; Nanjing University of Finance & Economics; Nanjing University
  摘要：We provide national-scale experimental evidence from China showing that transparency by local governments improves the management of air pollution. Governments that perform better have more reasons to be transparent, making the causal relationship between transparency and policy outcomes difficult to disentangle. In 2015, we randomly assigned municipal governments in China to a high-visibility, public rating of their adherence to national requirements for transparency about their regulation of...
• Disease resistance is more costly at younger ages: An explanation for the maintenance of juvenile susceptibility in a wild plant AI翻译
  作者：Slowinski, Samuel P.; Kido, Allyson K.; Alexander, Laura W.; Shirdon, Andrea H.; Bruns, Emily L.
  作者单位：University System of Maryland; University of Maryland College Park; University of New England - Maine; University System of Maryland; University of Maryland Baltimore; University of California System; University of California Berkeley; Indiana University System; Indiana University Bloomington
  摘要：High juvenile susceptibility drives infectious disease epidemics across kingdoms, yet the evolutionary mechanisms that maintain this susceptibility are unclear. We tested the hypothesis that juvenile susceptibility is maintained by high costs of resistance by quantifying the genetic correlation between host fitness and age-specific innate resistance to a fungal pathogen in a wild plant. We separately measured the resistance of 45 genetic families of the wild plant, Silene latifolia, to its end...
• The histone variant H2A.W restricts heterochromatic crossovers in Arabidopsis AI翻译
  作者：Son, Namil; Kim, Heejin; Kim, Jaeil; Park, Jihye; Byun, Dohwan; Park, Sang-jun; Kim, Hyein; Park, Yeong Mi; Bourguet, Pierre; Berger, Frederic; Choi, Kyuha
  作者单位：Pohang University of Science & Technology (POSTECH); Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI)
  摘要：Meiotic crossovers rearrange allele combinations and create offspring diversity. Crossovers occur nonrandomly along chromosomes, predominantly in distal euchromatin and less in pericentromeric heterochromatin marked with histone H3 lysine 9 dimethylation (H3K9me2) and the H2A variant H2A.W inArabidopsis thaliana. Loss of H3K9me2 increases heterochromatic crossovers, but how H2A.W affects crossover formation in pericentromeric regions is unknown. Here, we report that H2A.W is required to restri...