14期

最新文章

• Asymmetric arginine dimethylation of cytosolic RNA and DNA sensors by PRMT3 attenuates antiviral innate immunity (vol 120, e2214956120,2023) AI翻译
  作者：Zhu, Junji; Li, Xiong; Caia, Xiaolian; Zhoua, Ziwen; Liaoa, Qian; Liu, Xing; Wang, Jing; Xiao, Wuhan
  作者单位：Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Hubei Hongshan Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences
• Removing masculine defaults in the hiring process AI翻译
  作者：Cheryan, Sapna; Muragishi, Gregg A.
  作者单位：University of Washington; University of Washington Seattle
• Microparticle impact-induced bond strength in metals peaks with velocity AI翻译
  作者：Tang, Qi; Ichikawa, Yuji; Hassani, Mostafa
  作者单位：Cornell University; Tohoku University; Cornell University
  摘要：Supersonic impact of metallic microparticles onto metallic substrates generates extreme interfacial deformation and high contact pressures, enabling solid-state metallic bonding. Although higher impact velocities are generally believed to improve bond quality and mechanical properties in materials formed by supersonic impact deposition, here we report a peak in bond strength for single microparticle impact bonding, followed by a decline at higher impact velocities. Our in situ micromechanical ...
• Breaking the mobility-stability dichotomy in organic semiconductors through adaptive surface doping AI翻译
  作者：Wang, Zhaofeng; Wu, Xianshuo; Zhang, Siyuan; Yang, Shuyuan; Gao, Pichao; Huang, Panhui; Xiao, Yanling; Shen, Xianfeng; Yao, Ximeng; Zeng, Dong; Jie, Jiansheng; Zhou, Yecheng; Yang, Fangxu; Li, Rongjin; Hu, Wenping
  作者单位：Tianjin University; Tianjin University; Collaborative Innovation Center of Chemical Science & Engineering Tianjin; Soochow University - China; Sun Yat Sen University
  摘要：Organic semiconductors (OSCs) are pivotal for next-generation flexible electronics but are limited by an intrinsic trade-off between mobility and stability. We introduce adaptive surface doping (ASD), an innovative strategy to overcome this dichotomy in OSCs. ASD's adaptive mechanism accommodates a broad range of dopant concentrations, optimally passivating trap states as needed. This approach significantly lowers the trap energy level from 84 meV to 14 meV above the valence band edge, promoti...
• Lung B cells in ectopic germinal centers undergo affinity maturation AI翻译
  作者：Guillaume, Stephane M.; Foster, William S.; Molina, Isabel San Martin; Watson, Emily M.; Innocentin, Silvia; Kennedy, Grant M.; Denton, Alice E.; Linterman, Michelle A.
  作者单位：UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Babraham Institute; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Babraham Institute; University of Warwick; Imperial College London
  摘要：The lungs are constantly exposed to the external environment and a myriad of antigenic challenges within the air. Chronic exposure to allergens and other airborne antigens can result in the formation of lymphocyte aggregates in the lung, which can harbor ectopic germinal centers (GCs). After allergen exposure, GCs that form in the lung are much smaller and less densely packed with B cells than lymph node GCs. Despite this, ectopic lung GCs support somatic hypermutation and affinity-based matur...
• MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis AI翻译
  作者：Sarkar, Lucky; Liu, GuanQun; Acharya, Dhiraj; Zhu, Junji; Sayyad, Zuberwasim; Gack, Michaela U.
  作者单位：McGill University; Cleveland Clinic Foundation
  摘要：The posttranslational modification (PTM) of innate immune sensor proteins by ubiquitin or ubiquitin-like proteins is crucial for regulating antiviral host responses. The cytoplasmic dsRNA receptor melanoma differentiation-associated protein 5 (MDA5) undergoes several PTMs including ISGylation within its first caspase activation and recruitment domain (CARD), which promotes MDA5 signaling. However, the relevance of MDA5 ISGylation for antiviral immunity in an infected organism has been elusive....
• RPE-specific MCT2 expression promotes cone survival in models of retinitis pigmentosa AI翻译
  作者：Chandler, Laurel C.; Gardner, Apolonia; Cepko, Constance L.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Howard Hughes Medical Institute; Harvard University; Harvard Medical School
  摘要：Retinitis pigmentosa (RP) is the most common cause of inherited retinal degeneration worldwide. It is characterized by the sequential death of rod and cone photoreceptors, the cells responsible for night and daylight vision, respectively. Although the expression of most RP genes occurs only in rods, there is a secondary degeneration of cones. One possible mechanism of cone death is metabolic dysregulation. Photoreceptors are highly metabolically active, consuming large quantities of glucose an...
• The cingulate cortex facilitates auditory perception under challenging listening conditions AI翻译
  作者：Anbuhl, Kelsey L.; Castro, Marielisa Diez; Lee, Nikki A.; Lee, Vivian S.; Sanes, Dan H.
  作者单位：New York University; Creighton University; New York University; New York University; New York University
  摘要：We often exert greater cognitive resources (i.e., listening effort) to understand speech under challenging acoustic conditions. This mechanism can be overwhelmed in those with hearing loss, resulting in cognitive fatigue in adults and potentially impeding language acquisition in children. However, the neural mechanisms that support listening effort are uncertain. Evidence from human studies suggests that the cingulate cortex is engaged under difficult listening conditions and may exert top-dow...
• Phase separation in the outer membrane of Escherichia coli (118, e2112237118, 2021) AI翻译
  作者：Benn, Georgina; V. Mikheyeva, Irina; Inns, Patrick George; Forster, Joel C.; Ojkic, Nikola; Bortolini, Christian; Ryadnov, Maxim G.; Kleanthous, Colin; Silhavy, Thomas J.; Hoogenboom, Bart W.