14期

最新文章

• Colony pattern multistability emerges from a bistable switch AI翻译
  作者：Chu, Pan; Zhu, Jingwen; Ma, Zhixin; Fu, Xiongfei
  作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Microbial colony development hinges upon a myriad of factors, including mechanical, biochemical, and environmental niches, which collectively shape spatial patterns governed by intricate gene regulatory networks. The inherent complexity of this phenomenon necessitates innovative approaches to comprehend and compare the mechanisms driving pattern formation. Here, we unveil the multistability of bacterial colony patterns, where bacterial colony patterns can stabilize into multiple distinct types...
• Quirks of track preservation and formation are more likely than pre- avian flight and ultrafast dinosaurs AI翻译
  作者：Falkingham, Peter L.; Lallensack, Jens N.
  作者单位：Liverpool John Moores University; Universidade Federal de Minas Gerais
• Validating new limits for human thermoregulation AI翻译
  作者：Meade, Robert D.; O'Connor, Fergus K.; Richards, Brodie J.; Tetzlaff, Emily J.; Wagar, Katie E.; Harris-Mostert, Roberto C.; Egube, Theodore; McCormick, James J.; Kenny, Glen P.
  作者单位：University of Ottawa; Harvard University; Harvard T.H. Chan School of Public Health; University of Ottawa; Ottawa Hospital Research Institute
  摘要：Recent projections suggest that large geographical areas will soon experience heat and humidity exceeding limits for human thermoregulation. The survivability limits modeled in that research were based on laboratory studies suggesting that humans cannot effectively thermoregulate in wet bulb temperatures (T-wb) above 26 to 31 degrees C, values considerably lower than the widely publicized theoretical threshold of 35 degrees C. The newly proposed empirical limits were derived from the T-wb corr...
• Structural and functional dynamics of human cone cGMP- phosphodiesterase important for photopic vision (vol 122, e2419732121, 2024) AI翻译
  作者：Singh, Sneha; Srivastava, Dhiraj; Boyd, Kimberly; Artemyev, Nikolai O.
• Signaling networks in cancer stromal senescent cells establish malignant microenvironment AI翻译
  作者：Zhang, Yue; Wang, Teh-Wei; Tamatani, Maho; Zeng, Xinyi; Nakamura, Lindo; Omori, Satotaka; Yamaguchi, Kiyoshi; Hatakeyama, Seira; Shimizu, Eigo; Yamazaki, Satoshi; Furukawa, Yoichi; Imoto, Seiya; Johmura, Yoshikazu; Nakanishi, Makoto
  作者单位：University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; Kanazawa University
  摘要：The tumor microenvironment (TME) encompasses various cell types, blood and lymphatic vessels, and noncellular constituents like extracellular matrix (ECM) and cytokines. These intricate interactions between cellular and noncellular components contribute to the development of a malignant TME, such as immunosuppressive, desmoplastic, angiogenic conditions, and the formation of a niche for cancer stem cells, but there is limited understanding of the specific subtypes of stromal cells involved in ...
• Asymmetric arginine dimethylation of cytosolic RNA and DNA sensors by PRMT3 attenuates antiviral innate immunity (vol 120, e2214956120,2023) AI翻译
  作者：Zhu, Junji; Li, Xiong; Caia, Xiaolian; Zhoua, Ziwen; Liaoa, Qian; Liu, Xing; Wang, Jing; Xiao, Wuhan
  作者单位：Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Hubei Hongshan Laboratory; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences
• Quina lithic technology indicates diverse Late Pleistocene human dynamics in East Asia AI翻译
  作者：Ruan, Qi-Jun; Li, Hao; Xiao, Pei-Yuan; Li, Bo; Monod, Helene; Sumner, Alexandra; Zhao, Ke-Liang; Liu, Jian- Hui; Jia, Zhen- Xiu; Wang, Chun- Xin; Fan, An- Chuan; Moncel, Marie- Helene; Marwick, Ben; Peresani, Marco; Wang, You-Ping; Chen, Fa-Hu; Delpiano, Davide
  作者单位：Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Tibetan Plateau Research, CAS; Center for Excellence in Tibetan Plateau Earth Sciences (CETES), CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Wollongong; University of Wollongong; Universitat Rovira i Virgili; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); DePaul University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Centre National de la Recherche Scientifique (CNRS); Museum National d'Histoire Naturelle (MNHN); CNRS - Institute of Ecology & Environment (INEE); University of Washington; University of Washington Seattle; University of Ferrara; Consiglio Nazionale delle Ricerche (CNR); Istituto di Geologia Ambientale e Geoingegneria (IGAG-CNR); Peking University
  摘要：The Late Pleistocene of Eurasia is key for understanding interactions between early modern humans and different types of archaic human groups. During this period, lithic technology shows more diversity and complexity, likely indicating flexible adaptative strategies. However, cultural variability as expressed by technological types remains vague in large parts of eastern Eurasia, like in China. Here, we report a complete Quina technological system identified from the study of the Longtan site ...
• Nuclear Galectin-1 promotes KRAS- dependent activation of pancreatic cancer stellate cells AI翻译
  作者：Vinaixa, Judith; Martinez-Bosch, Neus; Gibert, Joan; Manero-Ruperez, Noemi; Santofimia-Castano, Patricia; Baudou, Federico G.; Vera, Renzo E.; Pease, David R.; Iglesias, Mar; Sen, Sandhya; Wang, Xiyin; Almada, Luciana L.; Marks, David L.; Moreno, Mireia; Iovanna, Juan L.; Rabinovich, Gabriel A.; Fernandez-Zapico, Martin E.; Navarro, Pilar
  作者单位：Hospital del Mar Research Institute; Hospital del Mar; Hospital del Mar Research Institute; Hospital del Mar; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; UNICANCER; Centre National de la Recherche Scientifique (CNRS); Institut Paoli-Calmette (IPC); CNRS - National Institute for Biology (INSB); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Institute of Biology & Experimental Medicine; Universidad Nacional de Lujan; Mayo Clinic; Hospital del Mar Research Institute; Hospital del Mar; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; University of Buenos Aires; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
  摘要：Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, primarily due to its complex tumor microenvironment (TME), which drives both disease progression and therapy resistance. Understanding the molecular mechanisms governing TME dynamics is essential for developing new treatment strategies for this devastating disease. In this study, we uncover an oncogenic role for Galectin-1 (Gal1), a glycan-binding protein abundantly expressed by activated pancreatic stellate cells (...
• Elevated extinction risk in over one- fifth of native North American pollinators AI翻译
  作者：Cornelisse, Tara; Inouye, David W.; Irwin, Rebecca E.; Jepsen, Sarina; Mawdsley, Jonathan R.; Ormes, Margaret; Daniels, Jaret; Debinski, Diane M.; Griswold, Terry; Klymko, John; Orr, Michael C.; Richardson, Leif; Sears, Nicole; Schweitzer, Dale; Young, Bruce E.
  作者单位：United States Department of the Interior; United States Geological Survey; Nature Conservancy; University System of Maryland; University of Maryland College Park; North Carolina State University; State University System of Florida; University of Florida; Montana State University System; Montana State University Bozeman; United States Department of Agriculture (USDA); Utah System of Higher Education; Utah State University; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Zoology, CAS
  摘要：Pollinators are critical for food production and ecosystem function. Although native pollinators are thought to be declining, the evidence is limited. This first, taxonomically diverse assessment for mainland North America north of Mexico reveals that 22.6% (20.6 to 29.6%) of the 1,579 species in the best-studied vertebrate and insect pollinator groups have elevated risk of extinction. All three pollinating bat species are at risk and bees are the insect group most at risk (best estimate, 34.7...
• Monomers and short oligomers of human RAD52 promote single-strand annealing AI翻译
  作者：Kharlamova, Maria A.; Kushwah, Manish S.; Jachowski, Tobias J.; Subramaniam, Sivaraman; Schiff, Viktor; Stewart, A. Francis; Kukura, Philipp; Schaeffer, Erik
  作者单位：Eberhard Karls University of Tubingen; University of Oxford; Technische Universitat Dresden; University of New South Wales Sydney; Shandong University
  摘要：Genome maintenance and stability rely on the repair of DNA double-strand breaks. Breaks can be repaired via the single-strand-annealing pathway mediated by the protein RAD52. RAD52 oligomerizes to rings that are thought to promote annealing. However, rings have only been observed at micromolar concentrations at which annealing activity is impaired. Thus, it is unclear which oligomeric form is responsible for annealing. We combined single-molecule mass photometry with biochemical assays to dete...