14期

最新文章

• Digital phenotyping using smartphones could help steer mental health treatment AI翻译
  作者：Adam, David
• Reply to Brown et al.: Significant sex differences in accelerated cortical thinning associated with the COVID-19 lockdowns AI翻译
  作者：Corrigan, Neva M.; Rokem, Ariel; Kuhl, Patricia K.
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington Seattle; University of Washington; University of Washington Seattle
• Critical dynamics predicts cognitive performance and provides a common framework for heterogeneous mechanisms impacting cognition AI翻译
  作者：Mueller, Paul Manuel; Miron, Gadi; Holtkamp, Martin; Meisel, Christian
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin
  摘要：The brain criticality hypothesis postulates that brain dynamics are set at a phase transition where information processing is optimized. Long-range temporal correlations (TCs) characterizing the dissipation of information within a signal have been shown to be a hallmark of brain criticality. However, the experimental link between cognitive performance, criticality, and thus TCs has remained elusive due to limitations in recording length and spatial and temporal resolution. In this study, we in...
• Allosterically switchable network orients β-flap in Clostridioides difficile toxins AI翻译
  作者：Finn, Lauren M.; Cummer, Rebecca; Castagner, Bastien; Keller, Bettina G.
  作者单位：Free University of Berlin; McGill University
  摘要：Allosteric proteins exhibit a functional response upon ligand binding far from the active site. Clostridioides difficile toxins use allosteric binding by the endogenous cofactor myo-inositol hexakisphosphate to orchestrate self-cleavage from within the target cell. This binding event induces a conformational shift, primarily effecting a lever-like /3-flap region, with two known orientations. We uncovered a mechanism for this allosteric transition using extensive atomistic molecular dynamics si...
• Academic achievement helps coordination on mutually advantageous outcomes AI翻译
  作者：Brocas, Isabelle; Carrillo, Juan D.
  作者单位：University of Southern California; Centre for Economic Policy Research - UK
  摘要：This study examines the relationship between academic achievement and strategic ability to coordinate among middle school students. We designed an experimental framework using repeated asymmetric Battle of the Sexes and Hawk-Dove games, to explore how cognitive and social skills related to academic success influence behavior. A total of 132 students participated, divided into groups of high and low academic achievers based on their performance at school. Our results show that, on average, high...
• Transparency by Chinese cities reduces pollution violations and improves air quality AI翻译
  作者：Liu, Mengdi; Buntaine, Mark T.; Anderson, Sarah E.; Zhang, Bing
  作者单位：University of International Business & Economics; University of California System; University of California Santa Barbara; Nanjing University of Finance & Economics; Nanjing University
  摘要：We provide national-scale experimental evidence from China showing that transparency by local governments improves the management of air pollution. Governments that perform better have more reasons to be transparent, making the causal relationship between transparency and policy outcomes difficult to disentangle. In 2015, we randomly assigned municipal governments in China to a high-visibility, public rating of their adherence to national requirements for transparency about their regulation of...
• Disease resistance is more costly at younger ages: An explanation for the maintenance of juvenile susceptibility in a wild plant AI翻译
  作者：Slowinski, Samuel P.; Kido, Allyson K.; Alexander, Laura W.; Shirdon, Andrea H.; Bruns, Emily L.
  作者单位：University System of Maryland; University of Maryland College Park; University of New England - Maine; University System of Maryland; University of Maryland Baltimore; University of California System; University of California Berkeley; Indiana University System; Indiana University Bloomington
  摘要：High juvenile susceptibility drives infectious disease epidemics across kingdoms, yet the evolutionary mechanisms that maintain this susceptibility are unclear. We tested the hypothesis that juvenile susceptibility is maintained by high costs of resistance by quantifying the genetic correlation between host fitness and age-specific innate resistance to a fungal pathogen in a wild plant. We separately measured the resistance of 45 genetic families of the wild plant, Silene latifolia, to its end...
• The histone variant H2A.W restricts heterochromatic crossovers in Arabidopsis AI翻译
  作者：Son, Namil; Kim, Heejin; Kim, Jaeil; Park, Jihye; Byun, Dohwan; Park, Sang-jun; Kim, Hyein; Park, Yeong Mi; Bourguet, Pierre; Berger, Frederic; Choi, Kyuha
  作者单位：Pohang University of Science & Technology (POSTECH); Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI)
  摘要：Meiotic crossovers rearrange allele combinations and create offspring diversity. Crossovers occur nonrandomly along chromosomes, predominantly in distal euchromatin and less in pericentromeric heterochromatin marked with histone H3 lysine 9 dimethylation (H3K9me2) and the H2A variant H2A.W inArabidopsis thaliana. Loss of H3K9me2 increases heterochromatic crossovers, but how H2A.W affects crossover formation in pericentromeric regions is unknown. Here, we report that H2A.W is required to restri...
• Design of a halogen bond catalyzed DNA endonuclease AI翻译
  作者：Walker, Margaret G.; Mendez, Cesar Gustavo; Ho, Alexander N.; Czarny, Ryan S.; Rappe, Anthony K.; Ho, Pui Shing
  作者单位：Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins
  摘要：In this study, we expand the repertoire of biological catalysts by showing that a halogen bond (X-bond) can functionally replace the magnesium (Mg2+) cofactor in mouse endonuclease G (mEndoG). We mutated the metal coordinating glutamate E136 in mEndoG to a meta-halotyrosine (mXY, X = chlorine or iodine) to form a mXY-mEndoG construct that is both acid and base catalyzed. Under basic conditions, the enzyme is inactivated by the metal chelator ethylene diamine tetraacetic acid (EDTA), indicating...
• Painting rich six- dimensional pictures using polarized fluorescence microscopy AI翻译
  作者：Lew, Matthew D.
  作者单位：Washington University (WUSTL)