14期

最新文章

• Quirks of track preservation and formation are more likely than pre- avian flight and ultrafast dinosaurs AI翻译
  作者：Falkingham, Peter L.; Lallensack, Jens N.
  作者单位：Liverpool John Moores University; Universidade Federal de Minas Gerais
• Validating new limits for human thermoregulation AI翻译
  作者：Meade, Robert D.; O'Connor, Fergus K.; Richards, Brodie J.; Tetzlaff, Emily J.; Wagar, Katie E.; Harris-Mostert, Roberto C.; Egube, Theodore; McCormick, James J.; Kenny, Glen P.
  作者单位：University of Ottawa; Harvard University; Harvard T.H. Chan School of Public Health; University of Ottawa; Ottawa Hospital Research Institute
  摘要：Recent projections suggest that large geographical areas will soon experience heat and humidity exceeding limits for human thermoregulation. The survivability limits modeled in that research were based on laboratory studies suggesting that humans cannot effectively thermoregulate in wet bulb temperatures (T-wb) above 26 to 31 degrees C, values considerably lower than the widely publicized theoretical threshold of 35 degrees C. The newly proposed empirical limits were derived from the T-wb corr...
• Structural and functional dynamics of human cone cGMP- phosphodiesterase important for photopic vision (vol 122, e2419732121, 2024) AI翻译
  作者：Singh, Sneha; Srivastava, Dhiraj; Boyd, Kimberly; Artemyev, Nikolai O.
• Signaling networks in cancer stromal senescent cells establish malignant microenvironment AI翻译
  作者：Zhang, Yue; Wang, Teh-Wei; Tamatani, Maho; Zeng, Xinyi; Nakamura, Lindo; Omori, Satotaka; Yamaguchi, Kiyoshi; Hatakeyama, Seira; Shimizu, Eigo; Yamazaki, Satoshi; Furukawa, Yoichi; Imoto, Seiya; Johmura, Yoshikazu; Nakanishi, Makoto
  作者单位：University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo; Kanazawa University
  摘要：The tumor microenvironment (TME) encompasses various cell types, blood and lymphatic vessels, and noncellular constituents like extracellular matrix (ECM) and cytokines. These intricate interactions between cellular and noncellular components contribute to the development of a malignant TME, such as immunosuppressive, desmoplastic, angiogenic conditions, and the formation of a niche for cancer stem cells, but there is limited understanding of the specific subtypes of stromal cells involved in ...
• LMX1B missense- perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization AI翻译
  作者：Eastman, Brent; Tabuchi, Nobuko; Zhang, Xinrui L.; Spencer, William C.; Deneris, Evan S.
  作者单位：University System of Ohio; Case Western Reserve University
  摘要：Pathogenic coding mutations are prevalent in human neuronal transcription factors (TFs) but how they disrupt development is poorly understood. Lmx1b is a master transcriptional regulator of postmitotic Pet1 neurons that give rise to mature serotonin (5-HT) neurons; over two hundred pathogenic heterozygous mutations have been discovered in human LMX1B, yet their impact on brain development has not been investigated. Here, we developed mouse models with different LMX1B DNA-binding missense mutat...
• Prolonged signaling of backbone- modified glucagon-like peptide-1 analogues with diverse receptor trafficking AI翻译
  作者：Cary, Brian P.; Hager, Marlies V.; Mariam, Zamara; Morris, Rylie K.; Belousoff, Matthew J.; Deganutti, Giuseppe; Sexton, Patrick M.; Wootten, Denise; Gellman, Samuel H.
  作者单位：University of Wisconsin System; University of Wisconsin Madison; Monash University; Monash University; Coventry University
  摘要：Signal duration and subcellular location are emerging as important facets of G protein-coupled receptor (GPCR) function. The glucagon-like peptide-1 receptor (GLP-1R), a clinically relevant class B1 GPCR, stimulates production of the second messenger cyclic adenosine monophosphate (cAMP) upon activation by the native hormone, GLP-1. cAMP production continues after the hormone-receptor complex has been internalized via endocytosis. Here, we report GLP-1 analogues that induce prolonged signaling...
• Stability of the cnidarian-dinoflagellate symbiosis is primarily determined by symbiont cell- cycle arrest AI翻译
  作者：Gorman, Lucy M.; Tivey, Trevor R.; Raymond, Evan H.; Ashley, Immy A.; Oakley, Clinton A.; Grossman, Arthur R.; Weis, Virginia M.; Davy, Simon K.
  作者单位：Victoria University Wellington; Cornell University; Boyce Thompson Institute for Plant Research; Carnegie Institution for Science; Oregon State University; Universite PSL
  摘要：The cnidarian-dinoflagellate symbiosis relies on the regulation of resident symbiont populations to maintain biomass stability; however, the relative importance of host regulatory mechanisms [cell-cycle arrest (CC), apoptosis (AP), autophagy (AU), and expulsion (EX)] during symbiosis onset and maintenance is largely unknown. Here, we inoculated a symbiont-free (aposymbiotic) model cnidarian (Exaiptasia diaphana: Aiptasia) with either its native symbiont Breviolum minutum or one of three non-na...
• Reply to Falkingham et al.: Trackway shows flap- running in feathered dinosaurs AI翻译
  作者：Dececchi, T. Alexander; Kim, Kyung Soo; Lockley, Martin G.; Larsson, Hans C. E.; Holtz Jr, Thomas H.; Farlow, James O.; Pittman, Michael
  作者单位：Dakota State University; University of Colorado System; University of Colorado Denver; McGill University; University System of Maryland; University of Maryland College Park; Smithsonian Institution; Smithsonian National Museum of Natural History; Purdue University System; Indiana University Purdue University Fort Wayne; Chinese University of Hong Kong
• Reactivation of memory- associated neurons induces downstream suppression of competing neuronal populations AI翻译
  作者：Norman, Jacob F.; Rahsepar, Bahar; Vena, Anna; Thunemann, Martin; Devor, Anna; Ramirez, Steve; White, John A.
  作者单位：Boston University; Boston University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Boston University
  摘要：Inducing apparent memory recall by tagging and optogenetically reactivating cells in the hippocampus was demonstrated over a decade ago. However, the hippocampal dynamics resulting from this reactivation remain largely unknown. While calcium imaging is commonly used as a measure of neuronal activity, GCaMP, the most common calcium indicator, cannot be used with optogenetic neuronal reactivation because both require blue light excitation. To resolve this overlap, we demonstrate optogenetic reac...
• Unveiling Cas8 dynamics and regulation within a transposon- encoded Cascade-TniQ complex AI翻译
  作者：Patel, Amun C.; Sinha, Souvik; Arantes, Pablo R.; Palermo, Giulia
  作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside
  摘要：The Vibrio cholerae Cascade-TniQ complex unveiled a new paradigm in biology, demonstrating that CRISPR-associated proteins can direct DNA transposition. Despite the tremendous potential of knocking-in genes at desired sites, the mechanisms underlying DNA binding and transposition remain elusive. In this system, a conformational change of the Cas8 protein is essential for DNA binding, yet how it occurs is unclear. Here, structural modeling and free energy simulations reconstruct the Cas8 helica...