14期

最新文章

• Dual genetic tracing demonstrates the heterogeneous differentiation and function of neuromesodermal progenitors in vivo AI翻译
  作者：Din, Hengwei; Liu, Zixin; Mou, Dialing; Tang, Muxue; Huang, Xiuzhen; Liu, Kuo; Zhang, Qianyu; Lui, Kathy O.; Zhou, Bin
  作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; ShanghaiTech University; Chinese University of Hong Kong; Prince of Wales Hospital; Chinese University of Hong Kong; Prince of Wales Hospital
  摘要：In recent decades, the traditional paradigm of three distinct germ layers formed during gastrulation has been revised with the identification of neuromesodermal progenitors (NMPs). These progenitors emerge during gastrulation and contribute to both the neural ectoderm, particularly the spinal cord, and the adjacent paraxial mesoderm [D. Henrique et al., Development 142, 2864-2875 (2015); R. J. Garriock et al., Development 142, 1628-1638 (2015); E. Tzouanacou et al., Dev. Cell 17, 365-376 (2009...
• Quina lithic technology indicates diverse Late Pleistocene human dynamics in East Asia AI翻译
  作者：Ruan, Qi-Jun; Li, Hao; Xiao, Pei-Yuan; Li, Bo; Monod, Helene; Sumner, Alexandra; Zhao, Ke-Liang; Liu, Jian- Hui; Jia, Zhen- Xiu; Wang, Chun- Xin; Fan, An- Chuan; Moncel, Marie- Helene; Marwick, Ben; Peresani, Marco; Wang, You-Ping; Chen, Fa-Hu; Delpiano, Davide
  作者单位：Chinese Academy of Sciences; Institute of Tibetan Plateau Research, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Wollongong; University of Wollongong; Universitat Rovira i Virgili; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); DePaul University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Museum National d'Histoire Naturelle (MNHN); University of Washington; University of Washington Seattle; University of Ferrara; Consiglio Nazionale delle Ricerche (CNR); Istituto di Geologia Ambientale e Geoingegneria (IGAG-CNR); Peking University
  摘要：The Late Pleistocene of Eurasia is key for understanding interactions between early modern humans and different types of archaic human groups. During this period, lithic technology shows more diversity and complexity, likely indicating flexible adaptative strategies. However, cultural variability as expressed by technological types remains vague in large parts of eastern Eurasia, like in China. Here, we report a complete Quina technological system identified from the study of the Longtan site ...
• Nuclear Galectin-1 promotes KRAS- dependent activation of pancreatic cancer stellate cells AI翻译
  作者：Vinaixa, Judith; Martinez-Bosch, Neus; Gibert, Joan; Manero-Ruperez, Noemi; Santofimia-Castano, Patricia; Baudou, Federico G.; Vera, Renzo E.; Pease, David R.; Iglesias, Mar; Sen, Sandhya; Wang, Xiyin; Almada, Luciana L.; Marks, David L.; Moreno, Mireia; Iovanna, Juan L.; Rabinovich, Gabriel A.; Fernandez-Zapico, Martin E.; Navarro, Pilar
  作者单位：Hospital del Mar Research Institute; Hospital del Mar; Hospital del Mar Research Institute; Hospital del Mar; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); UNICANCER; Institut Paoli-Calmette (IPC); Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Institute of Biology & Experimental Medicine; Universidad Nacional de Lujan; Mayo Clinic; Hospital del Mar Research Institute; Hospital del Mar; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; University of Buenos Aires; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
  摘要：Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, primarily due to its complex tumor microenvironment (TME), which drives both disease progression and therapy resistance. Understanding the molecular mechanisms governing TME dynamics is essential for developing new treatment strategies for this devastating disease. In this study, we uncover an oncogenic role for Galectin-1 (Gal1), a glycan-binding protein abundantly expressed by activated pancreatic stellate cells (...
• Cryo- ET suggests tubulin chaperones form a subset of microtubule lumenal particles with a role in maintaining neuronal microtubules (vol 122, e2404017121, 2025) AI翻译
  作者：Chakraborty, Saikat; Martinez-Sanchez, Antonio; Beck, Florian; Toro-Nahuelpan, Mauricio; Hwang, In-Young; Noh, Kyung-Min; Baumeister, Wolfgang; Mahamid, Julia
• Behavioral nudges prevent loan delinquencies at scale: A 13- million- person field experiment (vol 122,e2416708122,2025) AI翻译
  作者：Kuan, Robert; Blagg, Kristin; Castleman, Benjamin L.; Darolia, Rajeev; Matsudaira, Jordan D.; Milkman, Katherine L.; Turner, Lesley J.
• Cotranslational membrane insertion of the voltage-sensitive K plus channel KvAP AI翻译
  作者：Westerfield, Justin M.; Kozojedova, Petra; Juli, Cara; Metola, Ane; von Heijne, Gunnar
  作者单位：Stockholm University; Stockholm University
  摘要：Voltage-sensor domains (VSDs), found in many voltage-sensitive ion channels and enzymes, are composed of four transmembrane helices (TMHs), including the atypical, highly positively charged S4 helix. VSDs are cotranslationally inserted into the membrane, raising the question of how the highly charged S4 helix is integrated into the lipid bilayer as it exits the ribosome. Here, we have used force profile analysis (FPA) to follow the cotranslational insertion of the six-TMH KvAP voltage-sensitiv...
• Design of a halogen bond catalyzed DNA endonuclease AI翻译
  作者：Walker, Margaret G.; Mendez, Cesar Gustavo; Ho, Alexander N.; Czarny, Ryan S.; Rappe, Anthony K.; Ho, Pui Shing
  作者单位：Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins
  摘要：In this study, we expand the repertoire of biological catalysts by showing that a halogen bond (X-bond) can functionally replace the magnesium (Mg2+) cofactor in mouse endonuclease G (mEndoG). We mutated the metal coordinating glutamate E136 in mEndoG to a meta-halotyrosine (mXY, X = chlorine or iodine) to form a mXY-mEndoG construct that is both acid and base catalyzed. Under basic conditions, the enzyme is inactivated by the metal chelator ethylene diamine tetraacetic acid (EDTA), indicating...
• Painting rich six- dimensional pictures using polarized fluorescence microscopy AI翻译
  作者：Lew, Matthew D.
  作者单位：Washington University (WUSTL)
• No compelling evidence of sex differences in brain maturation during COVID-19 lockdowns when the sexes are compared statistically AI翻译
  作者：Brown, Andrew W.; Chung, Simon; Koscik, Timothy; Vorland, Colby J.; Maney, Donna L.
  作者单位：University of Arkansas System; University of Arkansas Medical Sciences; University of Arkansas System; University of Arkansas Medical Sciences; Indiana University System; Indiana University Bloomington; Emory University
• Cryo- EM structure of cyanopodophage A4 reveals a pentameric pre- ejectosome in the double- stabilized capsid AI翻译
  作者：Hou, Pu; Zhou, Rui-Qian; Jiang, Yong-Liang; Yu, Rong-Cheng; Du, Kang; Gan, Nanqin; Ke, Fei; Zhang, Qi-Ya; Li, Qiong; Zhou, Cong-Zhao
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Institute of Hydrobiology, CAS
  摘要：Upon infection, the podophages usually eject a couple of proteins from the capsid to form a transmembrane ejectosome on the host cell membrane that facilitates the ejection of viral genome. However, it remains unclear how these proteins of pre-ejectosome are finely assembled at the center of highly packaged genome. Here, we report the intact structure of Anabaena cyanopodophage A4, which consists of a capsid stabilized by two types of cement proteins and a short tail attached with six tail fib...