14期

最新文章

• Biphasic mechanochemistry of single-chain polymerization AI翻译
  作者：Chakraborty, Udit Kumar; Yang, Muwen; Baral, Susil; Liu, Chunming; Chen, Anqi; Chen, Peng
  作者单位：Cornell University; California Institute of Technology; Illinois State University; University System of Ohio; University of Akron
  摘要：Mechanical forces can induce chemical reactions, produce chemical signals, and alter reaction kinetics. Here, using magnetic tweezers-based single-molecule force spectroscopy, we study the force effects on the ring-opening metathesis polymerization (ROMP) of single-polymer chains, during which nonequilibrium conformational entanglements can form and unravel stochastically. We find a surprising, biphasic force dependence of polymerization kinetics: The single-chain polymerization rate initially...
• Order-disorder transition in multidirectional crowds AI翻译
  作者：Bacik, Karol A.; Sobota, Grzegorz; Bacik, Bogdan S.; Rogers, Tim
  作者单位：Massachusetts Institute of Technology (MIT); University of Bath
  摘要：One of the archetypal examples of active flows is a busy concourse crossed by people moving in different directions according to their personal destinations. When the crowd is isotropic-comprising individuals moving in all different directions-the collective motion is disordered. In contrast, if it is possible to identify two dominant directions of motion, for example in a corridor, the crowd spontaneously organizes into contraflowing lanes or stripes. In this article, we characterize the phys...
• Onboard recordings reveal how bats maneuver under severe acoustic interference AI翻译
  作者：Goldshtein, Aya; Mazar, Omer; Harten, Lee; Amichai, Eran; Assa, Reut; Levi, Anat; Orchan, Yotam; Toledo, Sivan; Nathan, Ran; Yovel, Yossi
  作者单位：University of Konstanz; Max Planck Society; University of Konstanz; Tel Aviv University; Tel Aviv University; Hebrew University of Jerusalem; Hebrew University of Jerusalem; Tel Aviv University; Tel Aviv University
  摘要：Echolocating bats rely on active acoustic sensing to perceive their environment. When multiple bats fly together, echolocating simultaneously, the calls emitted by nearby conspecifics could interfere with and mask the echoes necessary for orientation. Nowhere is this impairment of sensing more dramatic than when thousands of bats emerge from a cave at the same time. Here, we tracked the movement of tens of greater mouse- tailed bats flying within a group of thousands. By mounting miniature mic...
• DDX54 downregulation enhances anti-PD1 therapy in immune- desert lung tumors with high tumor mutational burden AI翻译
  作者：Gong, Jeong - Ryeol; Lee, Jungeun; Han, Younghyun; Cho, Kwang-Hyun
  作者单位：Korea Advanced Institute of Science & Technology (KAIST)
  摘要：High tumor mutational burden (TMB-H) is a predictive biomarker for the responsiveness of cancer to immune checkpoint inhibitor (ICI) therapy that indicates whether immune cells can sufficiently recognize cancer cells as nonself. However, about 30% of all cancers from The Cancer Genome Atlas (TCGA) are classified as immune-desert tumors lacking T cell infiltration despite TMB-H. Since the underlying mechanism of these immune-desert tumors has yet to be unraveled, there is a pressing need to tra...
• The Hippo pathway and p27Kip1 cooperate to suppress mitotic regeneration in the organ of Corti and the retina AI翻译
  作者：Jahanshir, Eva; Llamas, Juan; Kim, Yeeun; Biju, Kevin; Oak, Sanyukta; Gnedeva, Ksenia
  摘要：The mature mammalian auditory sensory organ, the organ of Corti (OC), lacks the capacity for regenerating hair cells, leading to permanent hearing impairment. In contrast, the vestibular system has a limited capacity for hair cell regeneration, which we have shown to be further enhanced by inhibiting the Hippo pathway. Here, we demonstrate that, despite similar transcriptional responses, only vestibular and not auditory supporting cells proliferate as a result of Yap activation following Hippo...
• PHLPP2 is a pseudophosphatase that lost activity in the metazoan ancestor AI翻译
  作者：Husremovic, Tarik; Meier, Vanessa; Piech, Lucas; Siess, Katharina M.; Antonioli, Sumire; Grishkovskaya, Irina; Kircheva, Nikoleta; Angelova, Silvia E.; Wenzl, Karoline; Brandstaetter, Andreas; Veis, Jiri; Miocic-Stosic, Fran; Anrather, Dorothea; Hartl, Markus; Truebestein, Linda; Cerron-Alvan, Luis M.; Leeb, Martin; Zagrovic, Bojan; Hann, Stephan; Bock, Christoph; Ogris, Egon; Dudev, Todor; Irwin, Nicholas A. T.; Haselbach, David; Leonard, Thomas A.
  作者单位：Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); Medical University of Vienna; Vienna Biocenter (VBC); University of Vienna; Medical University of Vienna; Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); Bulgarian Academy of Sciences; University of Chemical Technology & Metallurgy - Bulgaria; BOKU University; University of Vienna; Medical University of Vienna; University of Vienna; Vienna Biocenter (VBC); Max F. Perutz Laboratories (MFPL); University of Vienna; University of Vienna; Austrian Academy of Sciences; Medical University of Vienna; University of Sofia; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI)
  摘要：The phosphoinositide 3- kinase (PI3K) pathway is a major regulator of cell and organisAkt, is observed in many human cancers. Pleckstrin homology domain leucine- rich repeat- containing protein phosphatases (PHLPP), two paralogous members of the metal- dependent protein phosphatase family, have been reported as negative regulators of Akt signaling and, therefore, tumor suppressors. However, the stoichiometry and identity of the bound metal ion(s), mechanism of action, and enzymatic specificity...
• A mechanically resilient soft hydrogel improves drug delivery for treating post-traumatic osteoarthritis in physically active joints AI翻译
  作者：Joshi, Nitin; Yan, Jing; Dang, Mickael; Slaughter, Kai; Wang, Yufeng; Wu, Dana; Ung, Trevor; Bhingaradiya, Nutan; Pandya, Virja; Chen, Mu Xian; Kaur, Shahdeep; Bhagchandani, Sachin; Alfassam, Haya A.; Joseph, John; Gao, Jingjing; Dewani, Mahima; Chu, Rachel Wai Chun; Yip, Ryan Chak Sang; Weldon, Eli; Shah, Purna; Pisal, Nishkal Dhiraj; Shukla, Chetan; Sherman, Nicholas E.; Luo, James N.; Conway, Thomas; Eickhoff Jr, James P.; Botelho, Luis; Alhasan, Ali H.; Karp, Jeffrey M.; Ermann, Joerg
  作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Massachusetts Institute of Technology (MIT); Harvard University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University
  摘要：Intra-articular delivery of disease-modifying osteoarthritis drugs (DMOADs) is likely to be most effective in the early stages of post-traumatic osteoarthritis (PTOA), when symptoms are minimal, and patients remain physically active. To ensure effective therapy, DMOAD delivery systems therefore must withstand repeated mechanical loading without altering the kinetics of drug release. While soft materials are typically preferred for DMOAD delivery, mechanical loading can compromise their structu...
• Lenacapavir disrupts HIV-1 core integrity while stabilizing the capsid lattice AI翻译
  作者：Li, Chenglei; Burdick, Ryan C.; Siddiqui, Rokeya; Janaka, Sanath Kumar; Hsia, Ru-ching; Hu, Wei-Shau; Pathak, Vinay K.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
  摘要：Lenacapavir (GS- 6207; LEN) is a potent HIV- 1 capsid inhibitor approved for treating multidrug- resistant infection. LEN binds to a hydrophobic pocket between neighboring capsid (CA) proteins in hexamers and stabilizes the capsid lattice, but its effect on HIV- 1 capsids is not fully understood. Here, we labeled HIV- 1 capsids with green fluorescent protein fused to CA (GFP- CA) or a fluid- phase GFP content marker (cmGFP) to assess LEN's impact on HIV- 1 capsids. HIV- 1 cores labeled with GF...
• Therapeutic targeting of the NOTCH1 and neddylation pathways in T cell acute lymphoblastic leukemia AI翻译
  作者：Bertulfo, Kalay; Perez-Duran, Pablo; Miller, Hannah; Ma, Cindy; Ambesi-Impiombato, Alberto; Samon, Jeremy; Mackey, Adam; Lin, Wen- Hsuan Wendy; Ferrando, Adolfo A.; Palomero, Teresa
  作者单位：Columbia University; Columbia University; Columbia University; Columbia University; Bristol-Myers Squibb
  摘要：Gamma Secretase Inhibitors (GSIs) effectively block oncogenic Notch homolog-1 (NOTCH1), a characteristic feature of T cell acute lymphoblastic leukemias (T-ALL). However, their clinical application has been stalled by the induction of severe gastrointestinal toxicity resulting from the inhibition of NOTCH signaling in the gut, which translates into increased goblet cell differentiation. Genome-wide CRISPR loss-of-function screen in the colon cancer cell line LS174T identified the neddylation p...
• Colony pattern multistability emerges from a bistable switch AI翻译
  作者：Chu, Pan; Zhu, Jingwen; Ma, Zhixin; Fu, Xiongfei
  作者单位：Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：Microbial colony development hinges upon a myriad of factors, including mechanical, biochemical, and environmental niches, which collectively shape spatial patterns governed by intricate gene regulatory networks. The inherent complexity of this phenomenon necessitates innovative approaches to comprehend and compare the mechanisms driving pattern formation. Here, we unveil the multistability of bacterial colony patterns, where bacterial colony patterns can stabilize into multiple distinct types...