15期

最新文章

• Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4 AI翻译
  作者：Jiang, Mengting; Xu, Youwei; Luan, Xiaodong; Wu, Kai; Li, Zhen; Xu, H. Eric; Zhang, Shuyang; Jiang, Yi; Yin, Wanchao
  作者单位：Lingang Laboratory; ShanghaiTech University; Nanjing University of Chinese Medicine; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College Hospital; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS
  摘要：The G protein-coupled cysteinyl leukotriene receptor CysLT2R plays intricate roles in the physiology and pathogenesis of inflammation-related processes. It has garnered increasing attention as a potential therapeutic target for atopic asthma, brain injury, central nervous system disorders, and various types of cancer. In this study, we present the cryo-electron microscopy structure of the cysteinyl leukotriene D4 (LTD4)-bound human CysLT2R in complex with a G alpha q protein, adopting an activ...
• Motion artifact-controlled micro-brain sensors between hair follicles for persistent augmented reality brain-computer interfaces AI翻译
  作者：Kim, Hodam; Kim, Ju Hyeon; Lee, Yoon Jae; Lee, Jimin; Han, Hyojeong; Yi, Hoon; Kim, Hyeonseok; Kim, Hojoong; Kang, Tae Woog; Chung, Suyeong; Ban, Seunghyeb; Lee, Byeongjun; Lee, Haran; Im, Chang-Hwan; Cho, Seong J.; Sohn, Jung Woo; Yu, Ki Jun; Kang, June; Yeo, Woon-Hong
  作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Yonsei University; Inha University; University System of Georgia; Georgia Institute of Technology; Hanyang University; Kumoh National University Technology; Chungnam National University; Kumoh National University Technology; Yonsei University; University System of Georgia; Georgia Institute of Technology; Emory University; University System of Georgia; Georgia Institute of Technology
  摘要：Modern brain-computer interfaces (BCI), utilizing electroencephalograms for bidirectional human-machine communication, face significant limitations from movement-vulnerable rigid sensors, inconsistent skin-electrode impedance, and bulky electronics, diminishing the system's continuous use and portability. Here, we introduce motion artifact-controlled micro-brain sensors between hair strands, enabling ultralow impedance density on skin contact for long-term usable, persistent BCI with augmented...
• Two transcription factors play critical roles in mediating epigenetic regulation of fruit ripening in tomato AI翻译
  作者：Niu, Qingfeng; Xu, Yaping; Huang, Huan; Li, Linzhu; Tang, Dengguo; Wu, Siqun; Liu, Ping; Liu, Ruie; Ma, Yu; Zhang, Bo; Zhu, Jian-Kang; Lang, Zhaobo
  作者单位：Anhui Agricultural University; Southern University of Science & Technology; Southern University of Science & Technology; Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; Zhejiang University
  摘要：DNA methylation regulates fruit ripening in tomato, and disruption of the DNA ylation and impaired ripening. We report here that the transcription factors Ripening Inhibitor (RIN) and FRUITFULL 1 (FUL1) play critical roles in mediating the effect of DNA methylation on tomato fruit ripening. RIN and FUL1 are silenced in dml2 mutant plants, and the defective ripening phenotype of dml2 is mimicked by the rin/ ful1 double mutant. Restoration of RIN expression in dml2 partially rescues its ripening...
• Unsupervised learning of structural relaxation in supercooled liquids from short-term fluctuations AI翻译
  作者：Qiu, Yunrui; Jang, Inhyuk; Huang, Xuhui; Yethiraj, Arun
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of Wisconsin System; University of Wisconsin Madison
  摘要：Unraveling the relationship between structural information and the dynamic properties of supercooled liquids is one of the great challenges of physics. Dynamic heterogeneity, characterized by the propensity of particles, is often used as a proxy for dynamic slowing. Over the years, significant efforts have been made to capture the structural variations linked to dynamic heterogeneity in supercooled liquids. In this work, we present an innovative unsupervised machine learning protocol based on ...
• Activity of spinal RORβ neurons is related to functional improvements following combination treatment after complete SCI AI翻译
  作者：Stachowski, Nicholas J.; Wheel, Jaimena H.; Singh, Shayna; Atoche, Sebastian J.; Yao, Lihua; Garcia-Ramirez, D. Leonardo; Giszter, Simon F.; Dougherty, Kimberly J.
  作者单位：Drexel University
  摘要：Various strategies targeting spinal locomotor circuitry have been associated with functional improvements after spinal cord injury (SCI). However, the neuronal populations mediating beneficial effects remain largely unknown. Using a combination therapy in a mouse model of complete SCI, we show that virally delivered brain-derived neurotrophic factor (BDNF) (AAV-BDNF) activates hindlimb stepping and causes hyperreflexia, whereas submotor threshold epidural stimulation (ES) reduces BDNF-induced ...
• ID3 enhances PD-L1 expression by restructuring MYC to promote colorectal cancer immune evasion AI翻译
  作者：Huang, Chuanzhong; Wang, Ling; Zhuo, Changhua; Chen, Wenxin; Fan, Hongmei; Hong, Yilin; Zhang, Yu; Zhou, Dongmei; Lin, Wansong; Zhang, Lingyu; Zhao, Jingjing; Chen, Shuping; Yu, Chundong; Ye, Yunbin
  作者单位：Fujian Medical University; Fujian Medical University; Xiamen University
  摘要：The inhibitor of DNA binding protein ID3 has been associated with the progression of colorectal cancer (CRC). Despite its significance, its specific role in the immune evasion strategies utilized by CRC remains unclear. RNA-seq analysis revealed that ID3 was positively associated with the PD-L1 immune checkpoint. We further demonstrated that tumor cell-expressed ID3 enhanced PD-L1 expression, suppressed the infiltration and activation of CD8+T cells, and facilitated the immune evasion of CRC c...
• The impact of sampling bias on preferences for skewed distributions in decisions from experience AI翻译
  作者：Vanunu, Yonatan; Newell, Ben R.
  作者单位：Tel Aviv University; Tel Aviv University; University of New South Wales Sydney
• The fruit fly, Drosophila melanogaster, as a microrobotics platform AI翻译
  作者：Iwasaki, Kenichi; Neuhauser, Charles; Stokes, Chris; Rayshubskiy, Aleksandr
  作者单位：Harvard University; Harvard University
  摘要：Engineering small autonomous agents capable of operating in the microscale environment remains a key challenge, with current systems still evolving. Our study explores the fruit fly, Drosophila melanogaster, a classic model system in biology and a species adept at microscale interaction, as a biological platform for microrobotics. Initially, we focus on remotely directing the walking paths of fruit flies in an experimental arena. We accomplish this through two distinct approaches: harnessing t...
• A monoclonal anti-hemagglutinin stem antibody modified with zanamivir protects against both influenza A and B viruses AI翻译
  作者：Liu, Xin; Balligand, Thomas; Le Gall, Camille; Ploegh, Hidde L.
  作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Program in Cellular & Molecular Medicine (PCMM); Harvard Medical School
  摘要：Influenza remains a significant public health threat. Both monoclonal antibodies and small-molecule inhibitors can target the influenza surface glycoproteins hemagglutinin (HA) or neuraminidase (NA) for prevention and treatment of influenza. Here, we combine the strengths of anti-influenza antibodies and small molecules by site-specific conjugation of the NA inhibitor zanamivir to MEDI8852, an HA-specific fully human monoclonal antibody. MEDI8852 targets the conserved stem region of HA and inh...
• Seismic fault slip at depths simulated by high- velocity friction experiments under hydrothermal conditions AI翻译
  作者：Yao, Lu; Feng, Wei; Cornelio, Chiara; Shimamoto, Toshihiko; Ma, Shengli; Di Toro, Giulio
  作者单位：China Earthquake Administration; Institute of Geology, CEA; University of Padua; Istituto Nazionale Geofisica e Vulcanologia (INGV)
  摘要：Seismic fault slip and rupture propagation often occur at crustal depths in the presence of hot and pressurized aqueous fluids (i.e., hydrothermal conditions). Previous experiments investigated fault frictional properties under hydrothermal conditions, but at imposed subseismic fault slip velocities (V similar to mu m/s). Here, using a rotary-shear apparatus equipped with a hydrothermal pressure vessel, we study friction at seismic slip velocities (V = 1.5 m/s) of gabbro-and marble-built fault...