15期

最新文章

• The Beholder's Share: Bridging art and neuroscience to study individual differences in subjective experience AI翻译
  作者：Durkin, Celia; Apicella, Marc; Baldassano, Christopher; Kandel, Eric; Shohamy, Daphna
  作者单位：Columbia University; Columbia University; Columbia University
  摘要：Our experience of the world is inherently subjective, shaped by individual history, knowledge, and perspective. Art offers a framework within which this subjectivity is practiced and promoted, inviting viewers to engage in interpretation. According to art theory, different forms of art-ranging from the representational to the abstract-challenge these interpretive processes in different ways. Yet, much remains unknown about how art is subjectively interpreted. In this study, we sought to elucid...
• Perturbing nuclear glycosylation in the mouse preimplantation embryo slows down embryonic development AI翻译
  作者：Formichetti, Sara; Serrano, Joana B.; Chitnavis, Urvashi; Sadowska, Agnieszka; Liu, Na; Boskovic, Ana; Boulard, Matthieu
  摘要：The main form of intracellular protein glycosylation (O-GlcNAc) is reversible and has been mapped on thousands of cytoplasmic and nuclear proteins, including RNA polymerase II, transcription factors, and chromatin modifiers. The O-GlcNAc modification is catalyzed by a single enzyme known as O-GlcNAc Transferase, that is required for mammalian early development. Yet, neither the regulatory function of protein O-GlcNAcylation in the embryo nor the embryonic O-GlcNAc proteome have been documented...
• FLIPL permits apoptotic and inflammatory signaling and inhibits necroptosis in mice without Caspase-8 oligomerization AI翻译
  作者：Shaw, Jeremy J. P.; Guy, Cliff; Tummers, Bart; Green, Douglas R.
  作者单位：St Jude Children's Research Hospital; University of London; King's College London
  摘要：Caspase- 8 signaling has proapoptotic, antinecroptotic, and proinflammatory signaling roles dependent on interaction with the adapter molecule FADD, oligomerization, and autocleavage. Previously, a Caspase- 8 binding partner cFLIPL (FLIP, encoded by Cflar) was shown to prevent Caspase- 8- dependent apoptosis, but permit Caspase- 8- dependent inhibition of necroptosis. We sought to explore the role of FLIP in Caspase- 8- dependent apoptosis induction, necroptosis inhibition, and inflammatory si...
• Astrocytic Ryk signaling coordinates scarring and wound healing after spinal cord injury AI翻译
  作者：Shen, Zhe; Feng, Bo; Lim, Wei Ling; Woo, Timothy; Liu, Yanlin; Vicenzi, Silvia; Wang, Jingyi; Kwon, Brian K.; Zou, Yimin
  作者单位：University of California System; University of California San Diego; University of British Columbia
  摘要：Wound healing after spinal cord injury involves highly coordinated interactions among multiple cell types, which are poorly understood. Astrocytes play a central role in creating a border against the non-neural lesion core. To do so, astrocytes undergo dramatic morphological changes by first thickening and elongating their processes and then overlapping them to form a physical barrier. We show here that the expression of a cell-surface receptor, Ryk, is induced in astrocytes after injury in bo...
• The RNA- binding protein RBPMS inhibits smooth muscle cell-driven vascular remodeling in atherosclerosis and vascular injury (vol 122, e2415933122, 2025) AI翻译
  作者：Du, Jianlin; Yuan, Xin; Wang, Jiajia; Zhang, Lujun; Tan, Fangyan; Hu, Tianyang; Li, Xingsheng; Liu, Fan; Ran, Haitao; Wang, Zhigang; Li, Yongyong; Feng, Yuxing; Melgiri, N. D.; Cao, Yu; Jiang, Lihong; Huang, Rongzhong; Sun, Yang
  作者单位：Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Chongqing Medical University; Kunming University of Science & Technology; Kunming University of Science & Technology; Kunming University of Science & Technology
• Biallelic variants in the conserved ribosomal protein chaperone gene PDCD2 are associated with hydrops fetalis and early pregnancy loss AI翻译
  作者：Voyer, Anne - Marie Landry-; Holling, Tess; Mis, Emily K.; Hassani, Zabih Mir; Alawi, Malik; Ji, Weizhen; Jeffries, Lauren; Kutsche, Kerstin; Bachand, Francois; Lakhani, Saquib A.
  作者单位：University of Sherbrooke; University of Hamburg; University Medical Center Hamburg-Eppendorf; Yale University; University of Hamburg; University Medical Center Hamburg-Eppendorf
  摘要：Pregnancy loss is a major problem in clinical medicine with devastating consequences for families. Next generation sequencing has improved our ability to identify underlying molecular causes, though over half of all cases lack a clear etiology. Here, we began with clinical evaluation combined with exome sequencing across independent families to identify bi-allelic candidate genetic variants in the Programmed Cell Death 2 (PDCD2) gene in multiple fetuses with nonimmune hydrops fetalis (NIHF). P...
• ZmGCT1/2 negatively regulate drought tolerance in maize by inhibiting ZmSLAC1 to maintain guard cell turgor AI翻译
  作者：Feng, Zhenkai; Li, Huiying; Sun, Zhihui; Cheng, Jinkui; Hua, Deping; Wang, Yu; Qi, Junsheng; Yang, Shuhua; Gong, Zhizhong
  作者单位：China Agricultural University; Hebei University
  摘要：Stomata, which are essential for the exchange of CO2 and water vapor between plant leaves and the atmosphere, are regulated by a variety of environmental and internal factors. In this study, we identified and characterized two genes, Guard Cell Turgor Maintaining 1 (GCT1) and its closest homolog GCT2, which encode rapidly accelerated fibrosarcoma (RAF)- like protein kinases that play a critical role in maintaining guard cell turgor in Zea mays. We found that overexpression of ZmGCT1 and ZmGCT2...
• New Advanced Placement course designed to broaden access promotes participation and demographic diversity in computer science education AI翻译
  作者：Ganelin, Daniela; Dee, Thomas S.
  作者单位：Stanford University
  摘要：Advanced Placement (AP) provides college-level courses to over 1 million US secondary students annually. Black, Hispanic, and female students have historically been underrepresented in AP Computer Science (CS). A new, broadly focused course-AP CS Principles-launched nationally in 2016-17 with the goal of increasing student participation and diversity. We examine its effects on AP CS participation. Combining publicly available sources, we assemble a panel dataset of annual AP exam-taking and co...
• Closure of orbits of the pure mapping class group in the character variety AI翻译
  作者：Golsefidy, Alireza S.; Tamam, Nattalie
  作者单位：University of California System; University of California San Diego
  摘要：The pure mapping class group of an oriented surface acts on the character variety of the surface. We investigate the closure of its orbits under either Zariski or analytic topologies. We show that a generic infinite orbit is dense in an open subset of the corresponding modified relative character variety. Moreover, we specify that being generic can be captured as a combination of passing to a Zariski-open subscheme and avoiding a concrete set of exceptional cases. In addition, the functorial b...
• On Hodge polynomials for nonalgebraic complex manifolds AI翻译
  作者：Katzarkov, Ludmil; Lee, Kyoung-Seog; Lupercio, Ernesto; Meersseman, Laurent
  作者单位：University of Miami; HSE University (National Research University Higher School of Economics); Bulgarian Academy of Sciences; Pohang University of Science & Technology (POSTECH); CINVESTAV - Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional; Centre National de la Recherche Scientifique (CNRS); Universite d'Angers
  摘要：Hodge theory is pivotal in studying algebraic varieties' intricate geometry and topology: it provides essential insights into their structure. The Hodge decomposition theorem establishes a profound link between the geometry of varieties and their cohomology groups, helping to understand their underlying properties. Moreover, Hodge theory was crucial at the inception of the field of mirror symmetry, revealing deep connections among seemingly disparate algebraic varieties. It also sheds light on...