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作者：Li, Ming; Chen, Zhe; Guo, Zhengyang; Wang, Yang; Chai, Yongping; Li, Wei; Ou, Guangshuo
作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University
摘要：The tubulin tail is a key element for microtubule (MT) functionality, but the functional redundancy of tubulin genes complicates the genetic determination of their physiological functions. Here, we removed the C-terminal tail of five alpha-and four beta-tubulin genes in the C. elegans genome. Sensory cilia typically exhibit an axoneme that longitudinally differentiates into a middle segment with doublet MTs and a distal segment with singlet MTs. However, the excision of the alpha-tubulin tail,...
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作者：Huang, Ling-Yun; Wang, Ting-Ting; Shi, Peng-Tao; Song, Ze-Yu; Chen, Wei-Fei; Liu, Na-Nv; Ai, Xia; Li, Hai-Hong; Hou, Xi-Miao; Wang, Li-Bing; Chen, Kun-Ming; Rety, Stephane; Xi, Xu-Guang
作者单位：Northwest A&F University - China; Northwest A&F University - China; Northwest A&F University - China; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); CHU Lyon; Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Universite Jean Monnet; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
摘要：NARROWLEAF 1 (NAL1), originally identified for its role in shaping leaf morphology, plant architecture, and various agronomic traits in rice, has remained enigmatic in terms of the molecular mechanisms governing its multifaceted functions. In this study, we present a comprehensive structural analysis of NAL1 proteins, shedding light on how NAL1 regulates the phase separation of its physiological substrate, FRIZZY PANICLE (FZP), a transcription factor. We determined that NAL1 assembles as a hex...
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作者：Rathbone, Harry W.; Houdusse, Anne
作者单位：Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite PSL; UNICANCER; Institut Curie
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作者：Mo, Xiaoyi; Meng, Keyu; Xu, Bohan; Li, Zehui; Lan, Shanwei; Ren, Zhengda; Xiang, Xin; Zou, Peiqian; Chen, Zesen; Lai, Zhongming; Ao, Xiang; Liu, Zhongyuan; Shang, Wanjing; Dai, Bingyang; Luo, Li; Xu, Jiajia; Wang, Zhizhang; Zhang, Zhongmin
作者单位：Southern Medical University - China; Southern Medical University - China; Southern Medical University - China; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Hong Kong Polytechnic University; Hong Kong Polytechnic University; Sun Yat Sen University
摘要：Increased differentiation or activity of osteoclasts is the key pathogenic factor of postmenois a novel posttranscriptional mRNA modification related to many diseases. However, its impact on regulating osteoclast activation in PMOP remains uncertain. Here, we initially observed that Nat10- mediated ac4C positively correlates with osteoclast differentiation of monocytes and low bone mass in PMOP. The specific knockout of Nat10 in monocytes and remodelin, a Nat10 inhibitor, alleviates ovariectom...
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作者：Ouyang, Xu; Zeng, Yixuan; Wang, Zi; Bo, Baichuan; Lai, Fangxing; Zhang, Chi; Qiu, Cheng-wei; Song, Qinghai; Yu, Shaohua; Kivshar, Yuri; Xiao, Shumin
作者单位：Harbin Institute of Technology; National University of Singapore; Australian National University; Shanxi University
摘要：The concept of a geometric phase has sparked a revolution in photonics. Conventional space- variant polarization manipulation in optical systems only results in broadband geometric phases. Recently emerged nonlocal metasurfaces show an ability to compress the operating bandwidth through modulations of wavelength- dependent amplitudes. However, their geometric phases are still broadband and not linear, posing severe challenges to realize ultra narrowband metadevices. Here, we propose and demons...
