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作者：Nchioua, Rayhane; Kmiec, Dorota; Krchlikova, Veronika; Mattes, Sarah; Noettger, Sabrina; Bibollet-Ruche, Frederic; Russell, Ronnie M.; Sparrer, Konstantin M. J.; Charpentier, Thomas; Tardy, Frederic; Bosinger, Steven E.; Sauter, Daniel; Hahn, Beatrice H.; Kirchhoff, Frank
作者单位：Ulm University; Eberhard Karls University of Tubingen; Eberhard Karls University Hospital; University of Pennsylvania; Helmholtz Association; German Center for Neurodegenerative Diseases (DZNE); Emory University
摘要：Zinc-finger antiviral protein (ZAP) is thought to drive the suppression of CpG dinucleotides in many viruses to mimic the composition of their host genomes. However, in vivo evidence is sparse. Here, we investigated the reasons for unusually high CpG levels in SIVmus and SIVmon from mustached and mona monkeys, descendants of one of the precursors of HIV-1. We show that SIVmus is not resistant to ZAP inhibition. Instead, these Cercopithecus monkey hosts differ from other primate species by a sp...
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作者：Olschewski, Sebastian; Spektor, Mikhail S.; Le Mens, Gael
作者单位：University of Basel; University of Warwick; VinUniversity; University of Warwick; Pompeu Fabra University; Pompeu Fabra University; Barcelona School of Economics
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作者：Wijnakker, Joost J. A. P. M.; van Son, Gijs J. F.; Krueger, Daniel; van de Wetering, Willine J.; Lopez-Iglesias, Carmen; Schreurs, Robin; van Rijt, Fenna; Lim, Sangho; Lin, Lin; Peters, Peter J.; Isberg, Ralph R.; Janda, Claudia Y.; de Lau, Wim; Clevers, Hans
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作者：Rosen, Matthew C.; Freedman, David J.
作者单位：University of Chicago; University of Chicago
摘要：Humans and other animals are adept at learning to perform cognitively demanding behavioral tasks. Neurophysiological recordings in nonhuman primates during such tasks find that the requisite cognitive variables are encoded strongly in core oculomotor brain regions. Here, we assembled a large dataset-11 monkeys performing an abstract visual categorization task, surveyed across more than 1,000 neural recording sessions- to reveal that this produces a robust but uninstructed behavioral tell, obse...
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作者：Tants, Jan-Niklas; Walbrun, Andreas; Kollwitz, Lucas; Friedrich, Katharina; Rief, Matthias; Schlundt, Andreas
作者单位：Goethe University Frankfurt; Goethe University Frankfurt; Technical University of Munich; Universitat Greifswald
摘要：The interaction of mRNA and regulatory proteins is critical for posttranscriptional control. For proper function, these interactions, as well as the involved protein and RNA structures, are highly dynamic, and thus, mechanistic insights from structural biology are challenging to obtain. In this study, we employ a multifaceted approach combining single-molecule force spectroscopy (SMFS) with NMR spectroscopy to analyze the concerted interaction of the two RNA-binding interfaces (A-site and B-si...
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作者：Yang, Ge; Huang, Jiajia; Gu, Weizhi; Lin, Zhongyuan; Wang, Qingyu; Kang, Rong; Liu, Jing - Yao; Sun, Zhihu; Zheng, Xusheng; Jiao, Long; Jiang, Hai - Long
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Jilin University
摘要：The microenvironment around catalytic sites plays crucial roles in enzymatic catalysis while its precise control in heterogeneous catalysts remains challenging. Herein, the coordinatively unsaturated metal nodes of Hf- based metal- organic framework nanosheets are simultaneously codecorated with catalytically active Co(salen) units and adjacent pyridyl- substituted alkyl carboxylic acids via a post modification route. By varying pyridyl- substituted alkyl carboxylic acids, the spatial position...
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作者：Carozza, Sofia; Kletenik, Isaiah; Astle, Duncan; Schwamm, Lee; Dhand, Amar
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; University of Cambridge; University of Cambridge; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); Yale University; Yale University
摘要：White matter develops over the course of childhood in an experience-dependent manner. However, its role in the relationship between the early environment and later cognition is unclear, in part due to focus on changes in specific gray matter regions. This study examines white matter differences across adolescents from diverse environments, evaluating both their extent throughout the brain and their contribution to cognitive outcomes. Using data from the Adolescent Brain Cognitive Development (...
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作者：Fan, Yijie; Xu, Yihong; Bian, Renji; Zhang, Ruan; Mei, Junning; Wu, Jiaxin; Xie, Binghe; Zhu, Shuangxing; Chen, Yu; Gu, Feifan; Liu, Ying; Taniguchi, Takashi; Watanabe, Kenji; Liu, Fucai; Cai, Xinghan
作者单位：Shanghai Jiao Tong University; Shanghai Jiao Tong University; University of Electronic Science & Technology of China; National Institute for Materials Science; University of Electronic Science & Technology of China; University of Electronic Science & Technology of China
摘要：Magnetic anisotropy plays a crucial role in determining the critical behavior and phase transitions in two- dimensional magnetic systems. It is also required for the design of thin- film spintronic devices. Despite its significance, sensing extremely weak anisotropy has proven challenging in van der Waals antiferromagnetic/ferrimagnetic materials. Here, we first employ simulations of micromagnetic energy function in few- layer easy- plane antiferromagnetic systems with a weak additional uniaxi...
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作者：Hintze, John; Fraumeni, Robert; de Haan, Noortje; Miller, Rebecca L.; Saraswat, Mayank; Yang, Zhang; Clausen, Henrik; Marth, Jamey D.
作者单位：Sanford Burnham Prebys Medical Discovery Institute; University of Copenhagen; Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC
摘要：The hepatocyte Ashwell-Morell receptor (AMR) is the prototypical mammalian lectin and the first cell receptor isolated. This recycling endocytic receptor of the plasma membrane determines the concentrations of hundreds of circulating glycoproteins the blood and plays important roles in host responses to and outcomes of infection. The compositional and topological determinants of a physiological AMR ligand have remained unclear with contradictory findings reported. Previous studies established ...
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作者：Wang, Jiayu; Zhang, Shilong; Li, Lingling; Wang, Xiaoliang; Xiong, Jiaofeng; Li, Qingning; Li, Weizheng; Yan, Feng
作者单位：Soochow University - China; Nanjing University; Donghua University
摘要：Solvents within gels enhance the mobility of polymer chain segments while concurrently diminishing interchain interactions, thereby facilitating the ductility of glassy polymers at the cost of their mechanical strength. Here, we develop a solvent toughening strategy for the preparation of highly compressible and high-strength ionogels in the glassy state. This approach leverages the synergistic effects of the slow dissociation-shift kinetics of solvent ionic liquids and polymer crystallization...
