15期

最新文章

• Transferring climate change physical knowledge AI翻译
  作者：Immorlano, Francesco; Eyring, Veronika; de Gouville, Thomas le Monnier; Accarino, Gabriele; Elia, Donatello; Mandt, Stephan; Aloisio, Giovanni; Gentine, Pierre
  作者单位：Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC); University of California System; University of California Irvine; Helmholtz Association; German Aerospace Centre (DLR); University of Bremen; Columbia University; Institut Polytechnique de Paris; Ecole Polytechnique; University of Salento
  摘要：Precise and reliable climate projections are required for climate adaptation and mitigation, but Earth system models still exhibit great uncertainties. Several approaches have been developed to reduce the spread of climate projections and feedbacks, yet those methods cannot capture the nonlinear complexity inherent in the climate system. Using a Transfer Learning approach, we show that Machine Learning can be used to optimally leverage and merge the knowledge gained from global temperature map...
• A continental view of climate effects on lakes AI翻译
  作者：Carpenter, Stephen R.
  作者单位：University of Wisconsin System; University of Wisconsin Madison
• Melting of nonreciprocal solids: How dislocations propel and fission in flowing crystals AI翻译
  作者：Poncet, Alexis; Le Blay, Marine; Irvine, William T. M.; Vitelli, Vincenzo; Bartolo, Denis; Guillet, Stephane
  作者单位：Ecole Normale Superieure de Lyon (ENS de LYON); Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Universite Paris Cite; Total SA; University of Chicago; University of Chicago
  摘要：When soft matter is driven out of equilibrium its constituents interact via effective interactions that escape Newton's action-reaction principle. Prominent examples include the hydrodynamic interactions between colloidal particles driven in viscous fluids, phoretic interactions between chemically active colloids, and quorum-sensing interactions in bacterial colonies. Despite a recent surge of interest in nonreciprocal physics, a fundamental question remains: do nonreciprocal interactions alte...
• Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia AI翻译
  作者：Charbonier, Frank; Zhu, Junqin; Slyman, Raleigh; Allan, Cole; Chaudhuri, Ovijit
  作者单位：Stanford University; Stanford University
  摘要：Collective migration of epithelial tissues is a critical feature of developmental morphogenesis and tissue homeostasis. Coherent motion of cell collectives requires large-scale coordination of motion and force generation and is influenced by mechanical properties of the underlying substrate. While tissue viscoelasticity is a ubiquitous feature of biological tissues, its role in mediating collective cell migration is unclear. Here, we have investigated the impact of substrate stress relaxation ...
• Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations AI翻译
  作者：Boccalini, Matteo; Berezovska, Yelyzaveta; Bussi, Giovanni; Paloni, Matteo; Barducci, Alessandro
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); International School for Advanced Studies (SISSA); University of London; University College London
  摘要：Biomolecular condensates are currently recognized to play a key role in organizing cellular space and in orchestrating biochemical processes. Despite an increasing interest in characterizing their internal organization at the molecular scale, not much is known about how the densely crowded environment within these condensates affects the structural properties of recruited macromolecules. Here, we adopted explicit-solvent all-atom simulations based on a combination of enhanced sampling approach...
• An integrated AI knowledge graph framework of bacterial enzymology and metabolism AI翻译
  作者：Spencer, Norman R.; Gunabalasingam, Mathusan; Dial, Keshav; Di, Xiaxia; Malcolm, Tonya; Magarvey, Nathan A.
  作者单位：McMaster University
  摘要：The study of bacterial metabolism holds immense significance for improving human health and advancing agricultural practices. The prospective applications of genomically encoded bacterial metabolism present a compelling opportunity, particularly in the light of the rapid expansion of genomic sequencing data. Current metabolic inference tools face challenges in scaling with large datasets, leading to increased computational demands, and often exhibit limited inter-relatability and interoperabil...
• A computational analysis of lexical elaboration across languages AI翻译
  作者：Khishigsuren, Temuulen; Regier, Terry; Vylomova, Ekaterina; Kemp, Charles
  作者单位：University of Melbourne; University of California System; University of California Berkeley; University of Melbourne
  摘要：Claims about lexical elaboration (e.g. Mongolian has many horse-related terms) are widespread in the scholarly and popular literature. Here, we show that computational analyses of bilingual dictionaries can be used to test claims about lexical elaboration at scale. We validate our approach by introducing BILA, a dataset including 1,574 bilingual dictionaries, and showing that it confirms 147 out of 163 previous claims from the literature. We then identify previously unreported examples of lexi...
• The importance of playing the long game when it comes to pandemic surveillance AI翻译
  作者：Shearer, Freya M.; Lipsitch, Marc
  作者单位：University of Melbourne; The Kids Research Institute Australia; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health
• Inactivation of microglial LXRβ in early postnatal mice impairs microglia homeostasis and causes long- lasting cognitive dysfunction AI翻译
  作者：Lv, Keyi; Luo, Yi; Liu, Tianyao; Xia, Meiling; Gong, Hong; Zhang, Dandan; Chen, Xuan; Jiang, Xin; Liu, Yulong; Liu, Jiayin; Cai, Yulong; Antonson, Per; Warner, Margaret; Xu, Haiwei; Gustafsson, Jan-Ake; Fan, Xiaotang
  作者单位：Army Medical University; Army Medical University; Karolinska Institutet; University of Houston System; University of Houston
  摘要：Microglia, the largest population of brain immune cells, play an essential role in regulating neuroinflammation by removing foreign materials and debris and in cognition by pruning synapses. Since liver X receptor beta (LXR beta) has been identified as a regulator of microglial homeostasis, this study examined whether its removal from microglia affects neuroinflammation and cognitive function. We used a cell-specific tamoxifen-inducible Cre-loxP-mediated recombination to remove LXR beta from m...
• Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit AI翻译
  作者：Paternoga, Helge; Xia, Lu; Paternoga, Lyudmila Dimitrova -; Li, Sihan; Yan, Liewei L.; Oestereich, Malte; Kasvandik, Sergo; Urs, Ankanahalli N. Nanjaraj; Beckert, Bertrand; Tenson, Tanel; Zaher, Hani; Inada, Toshifumi; Wilson, Daniel N.
  作者单位：University of Hamburg; University of Tokyo; Washington University (WUSTL); University of Tartu; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：The integrated stress response (ISR) is a central signaling network that enables eukaryotic cells to respond to a variety of different environmental stresses. Such stresses cause ribosome collisions that lead to activation of the kinase Gcn2, resulting in the phosphorylation and inactivation of eukaryotic initiation factor 2 and thereby promoting selective translation of mRNAs to restore homeostasis. Despite the importance of the ISR and intensive study over the past decades, structural insigh...