15期

最新文章

• Prolonged duration local anesthesia with minimal toxicity (vol 106, pg 7125, 2009) AI翻译
  作者：Epstein-Barash, Hila; Shichor, Iris; Kwon, Albert H.; Hall, Sherwood; Lawlor, Michael W.; Langer, Robert; Kohane, Daniel S.
• Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein AI翻译
  作者：Radic, Laura; Offersgaard, Anna; Kadava, Tereza; Zon, Ian; Capella-Pujol, Joan; Mulder, Fabian; Koekkoek, Sylvie; Spek, Vera; Chumbe, Ana; Bukh, Jens; van Gils, Marit J.; Sanders, Rogier W.; Yin, Victor C.; Heck, Albert J. R.; Gottwein, Judith M.; Sliepen, Kwinten; Schinkel, Janke
  作者单位：University of Amsterdam; University of Copenhagen; University of Copenhagen; Utrecht University; Utrecht University; Cornell University; Weill Cornell Medicine
  摘要：Hepatitis C virus (HCV) currently causes about one million infections and 240,000 deaths worldwide each year. To reach the goal set by the World Health Organization of global HCV elimination by 2030, it is critical to develop a prophylactic vaccine. Broadly neutralizing antibodies (bNAbs) target the E1E2 envelope glycoproteins on the viral surface, can neutralize a broad range of the highly diverse circulating HCV strains, and are essential tools to inform vaccine design. However, bNAbs target...
• Phosphatic stromatoporoid sponges formed reefs ∼480 Mya AI翻译
  作者：Jeon, Juwan; Roda, Mar Simonet; Chen, Zhong-Yang; Luo, Cui; Kershaw, Stephen; Kim, Daeyeong; Ma, Jun-Ye; Lee, Jeong- Hyun; Zhang, Yuan-Dong
  作者单位：Korea University; Chinese Academy of Sciences; Institute for Basic Science - Korea (IBS); Korea University; Chungnam National University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Brunel University; Natural History Museum London; Korea Polar Research Institute (KOPRI); Chungnam National University
  摘要：Stromatoporoid sponges were important reef-builders during the middle Paleozoic, yet their early history and integration into reef ecosystems remain poorly understood. Here, we report Lophiostroma leizunia Jeon sp. nov., the oldest known stromatoporoid from upper Tremadocian to lower Floian (similar to 480 My-old) strata of South China. L. leizunia formed complex reef structures, playing crucial roles in framework construction and binding other components, including calcimicrobes, lithistid sp...
• Structural basis of ZP2-targeted female nonhormonal contraception AI翻译
  作者：Dioguardi, Elisa; Stsiapanava, Alena; Fahrenkamp, Eileen; Han, Ling; de Sanctis, Daniele; Inzunza, Jose; Jovine, Luca
  作者单位：Karolinska Institutet; Karolinska Institutet; Chiesi Pharmaceuticals Inc
  摘要：Monoclonal antibody IE-3 prevents mouse fertilization by binding ZP2, a major component of the oocyte-specific zona pellucida (ZP). We show that an IE-3-derived single-chain variable fragment (scFV) is sufficient for blocking fertilization in vitro and determine the structural basis of IE-3/ZP2 recognition. The high affinity of this interaction depends on induced fit of the epitope, offering insights for nonhormonal contraceptive design without off-target effects.
• Indigenous Knowledge as a sole data source in habitat selection functions AI翻译
  作者：Gryba, Rowenna; Von Duyke, Andrew; Huntington, Henry P.; Adams, Billy; Frantz, Brower; Gatten, Justin; Harcharek, Qaiyaan; Sarren, Robert; Henry, Greg; Auger-Methe, Marie
  作者单位：University of British Columbia; University of British Columbia; University of British Columbia
  摘要：While Indigenous Knowledge (IK) contains a wealth of information on the behavior and habitat use of species, it is rarely included in the species-habitat models frequently used by Western species management authorities. As decisions from these authorities can limit access to species that are important culturally and for subsistence, exclusion of IK in conservation and management frameworks can negatively impact both species and Indigenous communities. In partnership with I & ntilde;upiat hunte...
• Richardson's law and the origins of alcohol research AI翻译
  作者：Mukerjee, Snigdha; Siciliano, Cody A.
  作者单位：Vanderbilt University
  摘要：Interest in the biological actions of alcohols, ethanol in particular, dates back to the earliest historical texts. Alcohol research is now a highly active field with roots in physiology, pharmacology, toxicology, and neuroscience. But at what point did interest and speculation evolve into bona fide science? Here, we set out to identify the earliest systematic empirical investigations into the biological actions of alcohols and unearthed a surprisingly rigorous literature which included a fund...
• The genetic legacy of a global marine invader AI翻译
  作者：Sotka, Erik E.; Carnegie, Ryan B.; Carlton, James T.; Couceiro, Lucia; Crooks, Jeffrey A.; Endo, Hikaru; Hayford, Hilary; Hori, Masakazu; Kamiya, Mitsunobu; Kanaya, Gen; Kochmann, Judith; Lee, Kun- Seop; Lees, Lauren; Miller, Hannah; Nakaoka, Masahiro; Pante, Eric; Ruesink, Jennifer L.; Schwindt, Evangelina; Strand, Asa; Taylor, Richard B.; Terada, Ryuta; Thiel, Martin; Yorisue, Takefumi; Zacherl, Danielle; Strand, Allan E.
  作者单位：College of Charleston; William & Mary; Virginia Institute of Marine Science; Williams College; Universidade da Coruna; Kagoshima University; Kagoshima University; Japan Fisheries Research & Education Agency (FRA); Tokyo University of Marine Science & Technology; National Institute for Environmental Studies - Japan; Johannes Gutenberg University of Mainz; Pusan National University; University of California System; University of California Irvine; Hokkaido University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Universite de Bretagne Occidentale; Ifremer; Institut de Recherche pour le Developpement (IRD); University of Washington; University of Washington Seattle; IVL Swedish Environmental Research Institute; University of Auckland; University of Auckland; Smithsonian Institution; Smithsonian Environmental Research Center; Universidad Catolica del Norte; University of Hyogo; California State University System; California State University Fullerton
  摘要：The massive geographic expansion of terrestrial plant crops, livestock, and marine aqua-cultured species during the 19th and 20th centuries provided local economic benefits, stabilized food demands, and altered local ecosystems. The invasion history of these translocations remains uncertain for most species, limiting our understanding of their future adaptive potential and historical roles as vectors for coinvaded species. We provide a framework for filling this gap in invasion biology using t...
• Neddylation modification stabilizes LC3B by antagonizing its ubiquitin- mediated degradation and promoting autophagy in skin AI翻译
  作者：Xu, Linlin; Lyu, Xinxing; Wang, Yibo; Ni, Li; Li, Pin; Zeng, Piao; Wang, Qixia; Chang, Yunhao; Pan, Chenglong; Hu, Qingxia; Huang, Shuhong; Dang, Ningning
  作者单位：Shandong First Medical University & Shandong Academy of Medical Sciences; Shandong University; Shandong First Medical University & Shandong Academy of Medical Sciences; Shandong First Medical University & Shandong Academy of Medical Sciences; Shandong First Medical University & Shandong Academy of Medical Sciences; Nanjing Medical University
  摘要：The Atg8-family proteins, including LC3B (microtubule-associated protein 1 light chain 3 beta), are pivotal for key steps in the autophagy process. Proper regulation of LC3B homeostasis is essential for its function. Although LC3B is modulated by various post-translational modifications (PTMs), the impact of these modifications on LC3B protein homeostasis remains unclear. Neddylation, a recently identified ubiquitin-like modification, plays diverse biological roles. Here, we identify LC3B as a...
• Structural and functional characterization of the brain- specific dynamin superfamily member RNF112 AI翻译
  作者：Zhong, Ya-Ting; Huang, Li-Li; Li, Kangning; Yang, Bingke; Ye, Xueting; Zhong, Hao-Ran; Yu, Bing; Ma, Menghan; Yuan, Yuerong; Meng, Yang; Pan, Runfeng; Zhang, Haiqing; Shi, Lijun; Wang, Yunyun; Tian, Ruijun; Gao, Song; Bian, Xin
  作者单位：State Key Lab Oncology South China; Sun Yat Sen University; Nankai University; Southern University of Science & Technology; Southern University of Science & Technology; Nankai University; Sun Yat Sen University; Chinese Academy of Sciences; Institute of Biophysics, CAS
  摘要：Most members of the dynamin superfamily of large guanosine triphophatases (GTPases) have an ability to remodel membranes in response to guanosine triphosphate (GTP) hydrolysis. Ring Finger Protein 112 (RNF112) (ZNF179/neurolastin) is a recently identified brain-specific dynamin-like protein possessing a really interesting new gene (RING) finger domain. Despite its essential role as an E3 ligase in neuron development, the architecture of RNF112 and the exact role of its GTPase activity remain u...
• SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss AI翻译
  作者：Xi, Xinqi; Liu, Ling; Tuano, Natasha; Tailhades, Julien; Mouradov, Dmitri; Steen, Jason; Sieber, Oliver; Cryle, Max; Nguyen-Dumont, Tu; Segelov, Eva; Rosenbluh, Joseph
  作者单位：Monash University; Monash University; Murdoch Children's Research Institute; Walter & Eliza Hall Institute; University of Melbourne; Monash University; University of Melbourne; University of Melbourne; University of Bern; University Hospital of Bern; University of Geneva; University of Bern; University Hospital of Bern; Monash University
  摘要：Loss of the tumor suppressor gene (TSG) Adenomatous Polyposis Coli (APC) is a hallmark event in colorectal cancers. Since it is not possible to directly target a TSG, no treatment options are available for these patients. Here, we identify SRPJ9 and the protein secretion machinery as a unique vulnerability in cancers with heterozygous APC loss. SRPJ9 is located 15 kb from APC and is almost always codeleted in these tumors. Heterozygous APC/SRPJ9 loss leads to lower levels of SRPJ9 mRNA and pro...