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作者：Tumini, Emanuela; Wellinger, Ralf E.; Moyano, Emilia Herrera-; Cansino, Patricia Navarro-; Rubio, Maria Garcia-; Lloret, Daniel Salas-; Losada, Alejandro; Munoz-Alonso, Maria J.; Gaillard, Helene; Luna, Rosa; Aguilera, Andres
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); University of Sevilla
摘要：DNA topoisomerase 1 (TOP1) is essential for transcription, replication, and repair. Its function relies on two catalytic steps, DNA breakage and rejoining. Inhibitors of the second step prevent DNA rejoining and lead to persistent DNA breaks, acting as topoisomerase poisons, used as anticancer drugs. However, reliable inhibitors of the first step are not available. Here, we provide genetic and molecular evidence supporting that Patulin and, to a lesser extent, Xestoquinol inhibit the first cat...
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作者：Zhang, Feng - Rui; Liu, Juan; Wen, Jieqi; Zhang, Zi- Yan; Li, Yijia; Song, Eric; Hu, Li; Chen, Zhou- Feng
作者单位：Washington University (WUSTL); Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shenzhen Bay Laboratory; Shenzhen Medical Academy of Research & Translation (SMART); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：Spontaneous rescue behavior enhances the well- being and survival of social animals, yet the neural mechanisms underlying the recognition and response to conspecifics in need remain unclear. Here, we report that observer mice experience distress when encountering anesthetized conspecifics, prompting spontaneous rescue- like behavior toward the unconscious mice. This behavior facilitates the earlier awakening of anesthetized mice while simultaneously alleviating stress in the helper mice. Our f...
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作者：Liu, Yunpeng; Scheiner, Samuel M.; Hogan, J. Aaron; Thomas, Matthew B.; Soltis, Pamela S.; Guralnick, Robert P.; Soltis, Douglas E.; Lichstein, Jeremy W.
作者单位：State University System of Florida; University of Florida; University of York - UK; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
摘要：Biological invasions are profoundly altering Earth's ecosystems, but generalities about the effects of nonnative species on the diversity and productivity of native communities have been elusive. This lack of generality may reflect the limited spatial and temporal extents of most previous studies. Using >5 million tree measurements across eastern US forests from 1995 to 2023, we quantified temporal trends in tree diversity and biomass. We then analyzed community- level changes in native tree d...
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作者：Filsinger, Gabriel T.; Mychack, Aaron; Lyerly, Evan; Henriksen, Camilla; Bartlett, Thomas M.; Kuchwara, Helene; Eitzinger, Simon; Bernhardt, Thomas G.; Walker, Suzanne; Church, George M.; Wannier, Timothy M.
作者单位：Harvard University; Harvard Medical School; Stanford University; Harvard University; University of Copenhagen; Wadsworth Center; State University of New York (SUNY) System; Harvard University; Harvard Medical School; Harvard University; Harvard University
摘要：Genome modification is essential for studying and engineering bacteria, yet making efficient modifications to most species remains challenging. Bacteriophage-encoded single-stranded DNA-annealing proteins (SSAPs) can facilitate efficient genome editing by homologous recombination, but their typically narrow host range limits broad application. Here, we demonstrate that a single library of 227 SSAPs enables efficient genome-editing across six diverse bacteria from three divergent classes: Actin...
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作者：Lizee, Mathieu; Esfandiar, Ali; Panoni, Eva; Mischenko, Artem; Taberna, Pierre-Louis; Simon, Patrice; Bocquet, Lyderic
作者单位：Max Planck Society; Fritz Haber Institute of the Max Planck Society; Universite Paris Cite; Universite PSL; Ecole Normale Superieure (ENS); Sharif University of Technology; University of Manchester; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite de Toulouse; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite Toulouse III - Paul Sabatier; Institut National Polytechnique de Toulouse
摘要：Transport of electrons and ions at carbon surfaces immersed in electrolytes is instrumental for a wide variety of membrane processes as well as energy storage in batteries and supercapacitors. Ion transport in a nanoporous electrode strongly depends on its electronic conductance and on the interfacial capacitance with the electrolyte. In this study, we use in-plane impedance spectroscopy to disentangle in-plane ionic and electronic transport on a single crystal graphene transistor covered by a...
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作者：Mukhi, Nitika; Brown, Hannah; Gorenkin, Danylo; Ding, Pingtao; Bentham, Adam R.; Stevenson, Clare E. M.; Jones, Jonathan D. G.; Banfield, Mark J.
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作者：Andersen, Camilla Gottlieb; Bavnhoj, Laust; Brag, Soren; Bohush, Anastasiia; Chrenkova, Adriana; Driller, Jan Heiner; Pedersen, Bjorn Panyella
作者单位：Aarhus University
摘要：The distribution of sugars is crucial for plant energy, signaling, and defense mechanisms. Sugar Transport Proteins (STPs) are Sugar Porters (SPs) that mediate proton-driven cellular uptake of glucose. Some STPs also transport fructose, while others remain highly selective for only glucose. What determines this selectivity, allowing STPs to distinguish between compounds with highly similar chemical composition, remains unknown. Here, we present the structure ofArabidopsis thaliana STP6 in an i...
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作者：Azimzadeh, Julien B.; Quinones, Patricia M.; Oghalai, John S.; Ricci, Anthony J.
作者单位：Stanford University; University of Southern California; University of Southern California; Stanford University
摘要：Although cochlear implants (CI) are the standard of care for profound sensorineural hearing loss they are technically constrained by the tendency of electrical current to spread within the fluid-filled chambers of the cochlea. This limits the resolution of individual electrodes and patients' perceptions of complex sounds. Infrared irradiation has been proposed as an alternative to electrical stimulation because it can elicit auditory responses while being spatially constrained, theoretically p...
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作者：Gabrieli, Tom; Tal, Yuval
作者单位：Ben-Gurion University of the Negev
摘要：Natural faults are typically nonplanar and exhibit multiple bends, which deviate from the general fault orientation at different angles. However, while such deviations are considered a key factor controlling earthquake propagation and, hence, its intensity and magnitude, direct experimental evidence of how bends affect earthquake ruptures is nearly nonexistent. Here, we present direct experimental observations of the interaction of dynamic frictional ruptures with fault (double-) bends of diff...
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作者：Ewart, Robert J.; Nastac, Michael L.; Bilbao, Pablo J.; Silva, Thales; Silva, Luis O.; Schekochihin, Alexander A.
作者单位：University of Oxford; University of Oxford; University of Oxford; Universidade de Lisboa; University of Oxford
摘要：Generic equilibria are derived for turbulent relaxing plasmas via an entropy-maximization procedure that accounts for the short-time conservation of certain collisionless invariants. The conservation of these collisionless invariants endows the system with a partial memory of its prior conditions but is imperfect on long time scales due to the development of a turbulent cascade to small scales, which breaks the precise conservation of phase volume, making this memory imprecise. The equilibria ...
