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作者：Weeks, Amy M.
作者单位：University of Wisconsin System; University of Wisconsin Madison
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作者：Girardeau, Anna R.; Enochs, Grace E.; Saltz, Julia B.
作者单位：Rice University
摘要：Evolutionary feedbacks occur when evolution in one generation alters the environment experienced by subsequent generations and are an expected result of indirect genetic effects (IGEs). Hypotheses abound for the role of evolutionary feedbacks in climate change, agriculture, community dynamics, population persistence, social interactions, the genetic basis of evolution, and more, but evolutionary feedbacks have rarely been directly measured experimentally, leaving open questions about how feedb...
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作者：Johnson, Katherine M.; Marley, Maxwell G.; Drizyte -Miller, Kristina; Chen, Jing; Cao, Hong; Mostafa, Nourhan; Schott, Micah B.; Mcniven, Mark A.; Razidlo, Gina L.
作者单位：Mayo Clinic; Mayo Clinic; Mayo Clinic; University of Nebraska System; University of Nebraska Medical Center
摘要：Rab32 is a small GTPase and molecular switch implicated in vesicular trafficking. Rab32 is also an A-Kinase Anchoring Protein (AKAP), which anchors cAMP-dependent Protein Kinase (PKA) to specific subcellular locations and specifies PKA phosphorylation of nearby substrates. Surprisingly, we found that a form of Rab32 deficient in PKA binding (Rab32 L188P) relocalized away from the Golgi apparatus and induced a marked disruption in Golgi organization, assembly, and dynamics. Although Rab32 L188P...
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作者：Keais, Graeme L.; Saad-Roy, Chadi M.; Gonzalez-Sqalli, Emmanuel; Powell, Candice N.; Rieseberg, Loren H.; Gawryluk, Ryan M. R.; van den Driessche, P.; Wei, Kevin H. -C.; Loppin, Benjamin; Perlman, Steve J.
作者单位：University of Victoria; University of British Columbia; University of British Columbia; University of California System; University of California Berkeley; University of California System; University of California Berkeley; CHU Lyon; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Universite Jean Monnet; Institut National de la Sante et de la Recherche Medicale (Inserm); CNRS - National Institute for Biology (INSB); University of Victoria; University of British Columbia
摘要：Meiotic drivers are selfish genetic elements that bias their own transmission during meiosis or gamete formation. Due to the fundamental differences between male and female meiosis in animals and plants, meiotic drivers operate through distinct mechanisms in the two sexes: In females, they exploit the asymmetry of meiosis to ensure their inclusion in the egg, whereas in males, they eliminate competing gametes after symmetric meiosis. Meiotic drive is commonly reported in males, where it strong...
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作者：Bhatia, Sudeep; van Baal, Simon T.; Wang, Feiyi; Walasek, Lukasz
作者单位：University of Pennsylvania; University of Leeds; University of Warwick
摘要：We present a dataset of over 100 K textual descriptions of real- life choice dilemmas, obtained from social media posts and large- scale survey data. Using large language models (LLMs), we extract hundreds of choice attributes at play in these dilemmas and map them onto a common representational space. This representation allows us to quantify the broader themes and specific trade- offs inherent in life choices and analyze how they vary across different contexts. We also present our dilemmas t...
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作者：Gaboriau, Theo; Marcionetti, Anna; Garcia-Jimenez, Alberto; Schmid, Sarah; Fitzgerald, Lucy M.; Micheli, Baptiste; Titus, Benjamin; Salamin, Nicolas
作者单位：University of Lausanne; University of Alabama System; University of Alabama Tuscaloosa
摘要：Clownfishes (Amphiprioninae) are a fascinating example of a marine radiation. From a central Pacific ancestor, they quickly colonized the coral reefs of the Indo-Pacific and diversified independently on each side of the Indo-Australian Archipelago. Their association with sea anemones has been proposed to be a key innovation that enabled the clownfish radiation. However, this intuition has little empirical or theoretical support given our current knowledge of the group. To date, no ecological v...
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作者：Gao, Forson; Ye, Fuzhou; Buck, Martin; Zhang, Xiaodong
作者单位：Imperial College London; Imperial College London; Francis Crick Institute; MRC Laboratory Molecular Biology; University of London; Royal Marsden NHS Foundation Trust; Institute of Cancer Research - UK
摘要：Bacterial RNA polymerase (RNAP) is a multisubunit enzyme that copies DNA into RNA in a process known as transcription. Bacteria use 6 factors to recruit RNAP to promoter regions of genes that need to be transcribed, with 60% bacteria containing at least one specialized 6 factor, 654. 654 recruits RNAP to promoters of genes associated with stress responses and forms a stable closed complex that does not spontaneously isomerize to the open state where promoter DNA is melted out and competent for...
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作者：Shi, Yuping; Roy, Partha P.; Higashitarumizu, Naoki; Lee, Tsung -Yen; Li, Quanwei; Javey, Ali; Landfester, Katharina; Mcculloch, Iain; Fleming, Graham R.
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Max Planck Society; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Japan Science & Technology Agency (JST); University of California System; University of California Berkeley; University of Oxford; Princeton University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Gandhinagar
摘要：A combination of ultrafast, long-range, and low-loss excitation energy transfer from the photoreceptor location to a functionally active site is essential for cost-effective polymeric semiconductors. Delocalized electronic wavefunctions along pi-conjugated polymer (CP) backbone can enable efficient intrachain transport, while interchain transport is gen erally thought slow and lossy due to weak chain-chain interactions. In contrast to the conventional strategy of mitigating structural disorder...
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作者：Zhang, Feng - Rui; Liu, Juan; Wen, Jieqi; Zhang, Zi- Yan; Li, Yijia; Song, Eric; Hu, Li; Chen, Zhou- Feng
作者单位：Washington University (WUSTL); Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Psychology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Shenzhen Bay Laboratory; Shenzhen Medical Academy of Research & Translation (SMART); Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：Spontaneous rescue behavior enhances the well- being and survival of social animals, yet the neural mechanisms underlying the recognition and response to conspecifics in need remain unclear. Here, we report that observer mice experience distress when encountering anesthetized conspecifics, prompting spontaneous rescue- like behavior toward the unconscious mice. This behavior facilitates the earlier awakening of anesthetized mice while simultaneously alleviating stress in the helper mice. Our f...
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作者：Liu, Yunpeng; Scheiner, Samuel M.; Hogan, J. Aaron; Thomas, Matthew B.; Soltis, Pamela S.; Guralnick, Robert P.; Soltis, Douglas E.; Lichstein, Jeremy W.
作者单位：State University System of Florida; University of Florida; University of York - UK; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
摘要：Biological invasions are profoundly altering Earth's ecosystems, but generalities about the effects of nonnative species on the diversity and productivity of native communities have been elusive. This lack of generality may reflect the limited spatial and temporal extents of most previous studies. Using >5 million tree measurements across eastern US forests from 1995 to 2023, we quantified temporal trends in tree diversity and biomass. We then analyzed community- level changes in native tree d...
