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作者：Weeks, Amy M.
作者单位：University of Wisconsin System; University of Wisconsin Madison
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作者：Girardeau, Anna R.; Enochs, Grace E.; Saltz, Julia B.
作者单位：Rice University
摘要：Evolutionary feedbacks occur when evolution in one generation alters the environment experienced by subsequent generations and are an expected result of indirect genetic effects (IGEs). Hypotheses abound for the role of evolutionary feedbacks in climate change, agriculture, community dynamics, population persistence, social interactions, the genetic basis of evolution, and more, but evolutionary feedbacks have rarely been directly measured experimentally, leaving open questions about how feedb...
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作者：Johnson, Katherine M.; Marley, Maxwell G.; Drizyte -Miller, Kristina; Chen, Jing; Cao, Hong; Mostafa, Nourhan; Schott, Micah B.; Mcniven, Mark A.; Razidlo, Gina L.
作者单位：Mayo Clinic; Mayo Clinic; Mayo Clinic; University of Nebraska System; University of Nebraska Medical Center
摘要：Rab32 is a small GTPase and molecular switch implicated in vesicular trafficking. Rab32 is also an A-Kinase Anchoring Protein (AKAP), which anchors cAMP-dependent Protein Kinase (PKA) to specific subcellular locations and specifies PKA phosphorylation of nearby substrates. Surprisingly, we found that a form of Rab32 deficient in PKA binding (Rab32 L188P) relocalized away from the Golgi apparatus and induced a marked disruption in Golgi organization, assembly, and dynamics. Although Rab32 L188P...
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作者：Keais, Graeme L.; Saad-Roy, Chadi M.; Gonzalez-Sqalli, Emmanuel; Powell, Candice N.; Rieseberg, Loren H.; Gawryluk, Ryan M. R.; van den Driessche, P.; Wei, Kevin H. -C.; Loppin, Benjamin; Perlman, Steve J.
作者单位：University of Victoria; University of British Columbia; University of British Columbia; University of California System; University of California Berkeley; University of California System; University of California Berkeley; CHU Lyon; Centre National de la Recherche Scientifique (CNRS); Ecole Normale Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1; Universite Jean Monnet; Institut National de la Sante et de la Recherche Medicale (Inserm); CNRS - National Institute for Biology (INSB); University of Victoria; University of British Columbia
摘要：Meiotic drivers are selfish genetic elements that bias their own transmission during meiosis or gamete formation. Due to the fundamental differences between male and female meiosis in animals and plants, meiotic drivers operate through distinct mechanisms in the two sexes: In females, they exploit the asymmetry of meiosis to ensure their inclusion in the egg, whereas in males, they eliminate competing gametes after symmetric meiosis. Meiotic drive is commonly reported in males, where it strong...
