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作者：Gomez, Ignacio Lopez; Wan, Zhong Yi; Zepeda-Nunez, Leonardo; Schneider, Tapio; Anderson, John; Sha, Fei
作者单位：Alphabet Inc.; Google Incorporated; California Institute of Technology
摘要：Regional high-resolution climate projections are crucial for many applications, such as agriculture, hydrology, and natural hazard risk assessment. Dynamical downscaling, the state-of-the-art method to produce localized future climate information, involves running a regional climate model (RCM) driven by an Earth System Model (ESM), but it is too computationally expensive to apply to large climate projection ensembles. We propose an approach combining dynamical downscaling with generative AI t...
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作者：Veenbaas, Seth D.; Koehn, Jordan T.; Irving, Patrick S.; Lama, Nicole N.; Weeks, Kevin M.
作者单位：University of North Carolina; University of North Carolina Chapel Hill
摘要：RNAs are critical regulators of gene expression, and their functions are often mediated by complex secondary and tertiary structures. Structured regions in RNA can selectively interact with small molecules-via well-defined ligandbinding pockets-to modulate the regulatory repertoire of an RNA. The broad potential to modulate biological function intentionally via RNA-ligand interactions remains unrealized, however, due to challenges in identifying compact RNA motifs with the ability to bind liga...
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作者：Wang, Jia-nan; Suo, Xiao-guo; Yu, Ju-tao; Luo, Qi-chao; Ji, Ming-lu; Zhang, Meng-meng; Zhu, Qi; Cheng, Xin-ran; Hou, Chao; Chen, Xin; Wang, Fang; Xu, Chuan-hui; Li, Chao; Xie, Shuai-shuai; Wei, Jie; Zhang, Dan-feng; Zhang, Xin-ru; Wang, Zhi-juan; Dong, Yu- hang; Zhu, Sai; Peng, Li-jin; Li, Xiang-yu; Chen, Hai-yong; Xu, Tao; Jin, Juan; Chen, Fei Xavier; Meng, Xiao-ming
作者单位：Anhui Medical University; Anhui Medical University; Anhui Medical University; Anhui Medical University; University of Hong Kong; University of Hong Kong; Fudan University
摘要：Inflammation plays an essential role in eliminating microbial pathogens and repairing tissues, while sustained inflammation accelerates kidney damage and disease progression. Therefore, understanding the mechanisms of the inflammatory response is vital for developing therapies for inflammatory kidney diseases like acute kidney injury (AKI), which currently lacks effective treatment. Here, we identified N-acetyltransferase 10 (NAT10) as an important regulator for acute inflammation. NAT10, the ...
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作者：Reich, Peter B.; Grace, Kathryn; Agrawal, Arun; Nagendra, Harini
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Notre Dame; Azim Premji Foundation; Azim Premji University Bengaluru
摘要：Mitigating climate change and social injustice are critical, interwoven challenges. Climate change is driven by grossly unequal contributions to elevated greenhouse gas emissions among individuals, socioeconomic groups, and nations. Yet, its deleterious impacts disproportionately affect poor and less powerful nations, and the poor and the less powerful within each nation. This climate injustice prompts a call for mitigation strategies that buffer the poorest and the most vulnerable against cli...
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作者：Dixon, Richard A.
作者单位：University of North Texas System; University of North Texas Denton; University of North Texas System; University of North Texas Denton
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作者：Faris, Shannon; Xia, Ke; Wagner, Andrew G.; Xu, Zihan; Smith, Nathan; Giner, Jose-Luis; Callahan, Brian; Xie, Jian; Wang, Chunyu
作者单位：Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; State University of New York (SUNY) System; University at Albany, SUNY; Binghamton University, SUNY; State University of New York (SUNY) System; University at Albany, SUNY; State University of New York (SUNY) College of Environmental Science & Forestry; University of Nebraska System; University of Nebraska Medical Center
摘要：Hedgehog (Hh) signaling plays fundamental roles in embryonic development while its abnormal activation in adults is associated with cancer. Hh targeting drugs have gained FDA approval but resistance emerged quickly, underlining the need for novel types of Hh inhibitors. Hh signaling is initiated by the Hh ligand, generated from the autoprocessing of Hh precursor. However, the catalytic role of a highly conserved Hedgehog residue C143 is still poorly understood. Here, we confirmed that C143 is ...
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作者：Weeks, Amy M.
作者单位：University of Wisconsin System; University of Wisconsin Madison
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作者：Tumini, Emanuela; Wellinger, Ralf E.; Moyano, Emilia Herrera-; Cansino, Patricia Navarro-; Rubio, Maria Garcia-; Lloret, Daniel Salas-; Losada, Alejandro; Munoz-Alonso, Maria J.; Gaillard, Helene; Luna, Rosa; Aguilera, Andres
作者单位：Consejo Superior de Investigaciones Cientificas (CSIC); University of Sevilla; Universidad Pablo de Olavide; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); University of Sevilla
摘要：DNA topoisomerase 1 (TOP1) is essential for transcription, replication, and repair. Its function relies on two catalytic steps, DNA breakage and rejoining. Inhibitors of the second step prevent DNA rejoining and lead to persistent DNA breaks, acting as topoisomerase poisons, used as anticancer drugs. However, reliable inhibitors of the first step are not available. Here, we provide genetic and molecular evidence supporting that Patulin and, to a lesser extent, Xestoquinol inhibit the first cat...
