17期

最新文章

• Proteostasis landscapes of cystic fibrosis variants reveal drug response vulnerability AI翻译
  作者：McDonald, Eli Fritz; Kim, Minsoo; Olson, John A.; Meiler, Jens; Plate, Lars
  作者单位：Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Leipzig University; Vanderbilt University; Vanderbilt University
  摘要：Cystic fibrosis (CF) is a lethal genetic disorder caused by variants in CF transmembrane conductance regulator (CFTR). Many variants are treatable with correctors, which enhance the folding and trafficking of CFTR. However, approximately 3% of persons with CF harbor poorly responsive variants. Here, we used affinity purification mass spectrometry proteomics to profile the protein homeostasis (proteostasis) changes of CFTR variants during correction to assess modulated interactions with protein...
• Prevalence of simplex compression in adversarial deep neural networks AI翻译
  作者：Cao, Yang; Chen, Yanbo; Liu, Weiwei
  作者单位：Wuhan University; Wuhan University; Wuhan University; Wuhan University
  摘要：Neural collapse (NC) reveals that the last layer of the network can capture data representations, leading to similar outputs for examples within the same class, while outputs for examples from different classes form a simplex equiangular tight frame (ETF) structure. This phenomenon has garnered significant attention due to its implications on the intrinsic properties of neural networks. Interestingly, we observe a simplex compression phenomenon in NC, where the geometric size of the simplex ET...
• Fungal Argonaute proteins act in bidirectional cross-kingdom RNA interference during plant infection AI翻译
  作者：Cheng, An-Po; Huang, Lihong; Oberkofler, Lorenz; Johnson, Nathan R.; Glodeanu, Adrian-Stefan; Stillman, Kyra; Weiberg, Arne
  作者单位：University of Munich; Universidad Mayor; University of Hamburg; Guangzhou Medical University
  摘要：Argonaute (AGO) proteins bind to small RNAs to induce RNA interference (RNAi), a conserved gene regulatory mechanism in animal, plant, and fungal kingdoms. Small RNAs of the fungal plant pathogen Botrytis cinerea were previously shown to translocate into plant cells and to bind to the host AGO, which induced cross-kingdom RNAi to promote infection. However, the role of pathogen AGOs during host infection stayed elusive. In this study, we revealed that members of fungal plant pathogen B. cinere...
• Biofilm architecture determines the dissemination of conjugative plasmids AI翻译
  作者：Djermoun, Sarah; Rode, Daniel K. H.; Jimenez-Siebert, Eva; Netter, Niklas; Lesterlin, Christian; Drescher, Knut; Bigot, Sarah
  作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Claude Bernard Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); University of Basel
  摘要：Plasmid conjugation is a contact-dependent horizontal gene transfer mechanism that significantly contributes to the dissemination of antibiotic resistance among bacteria. While the molecular mechanisms of conjugation have been extensively studied, our understanding of plasmid transfer dynamics within spatially structured bacterial communities and the influence of community architecture on plasmid dissemination remains limited. In this study, we use live-cell fluorescence microscopy to investig...
• Thermal homogenization of boreal communities in response to climate warming AI翻译
  作者：Makinen, Jussi; Ellis, Emilie E.; Antao, Laura H.; Davrinche, Andrea; Laine, Anna-Liisa; Saastamoinen, Marjo; Conenna, Irene; Hallforsa, Maria; Santangeli, Andrea; Kaarlejarvi, Elina; Heliolae, Janne; Huikkonen, Ida-Maria; Kuussaari, Mikko; Leinonen, Reima; Lehikoinen, Aleksi; Poyry, Juha; Suuronen, Anna; Salemaa, Maija; Tonteri, Tiina; Vuorio, Kristiina M.; Skjelbred, Birger; Jarvinen, Marko; Drakare, Stina; Carvalho, Laurence; Welk, Erik; Seidler, Gunnar; Vangansbeke, Pieter; Malis, Frantisek; Hedl, Radim; Auffret, Alistair G.; Plue, Jan; De Frenne, Pieter; Kalwij, Jesse M.; Vanhatalo, Jarno; Roslin, Tomas
  作者单位：University of Helsinki; Finnish Environment Institute; University of Turku; Consejo Superior de Investigaciones Cientificas (CSIC); ATTITUS Educacao; University of Helsinki; Natural Resources Institute Finland (Luke); Norwegian Institute for Water Research (NIVA); Swedish University of Agricultural Sciences; Martin Luther University Halle Wittenberg; Ghent University; Technical University Zvolen; Czech Academy of Sciences; Institute of Botany of the Czech Academy of Sciences; Palacky University Olomouc; Swedish University of Agricultural Sciences; Swedish University of Agricultural Sciences; Helmholtz Association; Karlsruhe Institute of Technology; University of Johannesburg; University of Helsinki; University of Helsinki
  摘要：Globally, rising temperatures are increasingly favoring warm-affiliated species. Although changes in community composition are typically measured by the mean temperature affinity of species (the community temperature index, CTI), they may be driven by different processes and accompanied by shifts in the diversity of temperature affinities and breadth of species thermal niches. To resolve the pathways to community warming in Finnish flora and fauna, we examined multidecadal changes in the domin...
• Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial- to- mesenchymal transition (vol 119, e2212879119, 2022) AI翻译
  作者：Piacentino, Michael L.; Hutchins, Erica J.; Andrews, Cecelia J.; Bronner, Marianne E.
• Phase transitions and dimensional cross-over in layered confined solids AI翻译
  作者：Wang, Yong; Wang, Junjie; Yao, Ge; Fan, Zheyong; Granato, Enzo; Kosterlitz, Michael; Ala-Nissila, Tapio; Car, Roberto; Sun, Jian
  作者单位：Nanjing University; Nanjing University; Collaborative Innovation Center of Advanced Microstructures (CICAM); Princeton University; Bohai University; Instituto Nacional de Pesquisas Espaciais (INPE); Brown University; Aalto University; Loughborough University; Princeton University
  摘要：The nature of solid phases and cross-over of order-disorder phase transitions from twodimensional (2D) layers to three-dimensional (3D) bulk in confined atomic systems remain largely unexplained. To this end, we consider noble gases and aluminum confined between graphene sheets at different pressures and temperatures. Using crystal structure search methods and molecular dynamics based on machine-learned potentials with quantum-mechanical accuracy, we identify structures of multilayer confined ...
• Pathogen growth and virulence dynamics drive the host evolution against coinfections AI翻译
  作者：Seal, Srijan; Basu, Dipendra Nath; Ghosh, Kripanjali; Ramachandran, Aryan; Kutum, Rintu; Shelke, Triveni; Gupta, Ishaan; Khan, Imroze
  作者单位：Ashoka University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Delhi
  摘要：The occurrence of coinfections, where hosts are simultaneously infected by multiple pathogens, is widespread in nature and has significant negative impacts on global health. In humans, over one-sixth of the world's population is affected by coinfections, contributing to several diseases. However, despite the broad ecological relevance and impact on global health, most biomedical research has focused on understanding interactions between a single host and a single pathogen. The extent to which ...
• The ins and outs of plant specialized metabolite gene organization AI翻译
  作者：Dixon, Richard A.
  作者单位：University of North Texas System; University of North Texas Denton; University of North Texas System; University of North Texas Denton
• Conserved C143 forms a branched intermediate in Hedgehog autoprocessing: A cancer drug discovery target against Hedgehog signaling AI翻译
  作者：Faris, Shannon; Xia, Ke; Wagner, Andrew G.; Xu, Zihan; Smith, Nathan; Giner, Jose-Luis; Callahan, Brian; Xie, Jian; Wang, Chunyu
  作者单位：Rensselaer Polytechnic Institute; Rensselaer Polytechnic Institute; State University of New York (SUNY) System; Binghamton University, SUNY; State University of New York (SUNY) System; State University of New York (SUNY) College of Environmental Science & Forestry; University of Nebraska System; University of Nebraska Medical Center
  摘要：Hedgehog (Hh) signaling plays fundamental roles in embryonic development while its abnormal activation in adults is associated with cancer. Hh targeting drugs have gained FDA approval but resistance emerged quickly, underlining the need for novel types of Hh inhibitors. Hh signaling is initiated by the Hh ligand, generated from the autoprocessing of Hh precursor. However, the catalytic role of a highly conserved Hedgehog residue C143 is still poorly understood. Here, we confirmed that C143 is ...