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作者：Wang, Xiaoyu; Finney, Joe; Sharpe, Aaron L.; Rodenbach, Linsey K.; Hsueh, Connie L.; Watanabe, Kenji; Taniguchi, Takashi; Kastner, M. A.; Vafek, Oskar; Goldhaber-Gordon, David
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作者：Ferrada, Evandro
作者单位：Universidad de Valparaiso; Universidad de Valparaiso
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作者：Gu, Jinge; Zhou, Xiaoming; Sutherland, Lillian; Liszczak, Glen; Mcknight, Steven L.
作者单位：University of Texas System; University of Texas Southwestern Medical Center; Westlake University
摘要：Protein domains of low sequence complexity are unable to fold into stable, three-dimensional structures. In test tube studies, these unusual polypeptide regions can self-associate in a manner causing phase separation from aqueous solution. This form of protein:protein interaction has been implicated in numerous examples of dynamic morphological organization within eukaryotic cells. In several cases, the basis for low complexity domain (LCD) self-association and phase separation has been traced...
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作者：Matalon, Nadav; Weinreb, Eyal; Freche, Dominik; Volk, Erez; Biron, Tirza; Moses, Elisha; Biron, David
作者单位：Weizmann Institute of Science; Hebrew University of Jerusalem; Weizmann Institute of Science; University of Chicago; University of Chicago
摘要：Prosody, the musical facet of speech, is pivotal in human communication, and its structure and meaning remain subjects of ongoing research. In this study, we introduce a data-driven model for English prosody, based on large-scale analysis of spontaneous conversations. As a first step, we identify approximately 200 discernible prosodic patterns-which we view as building blocks of the prosodic vocabulary-and outline their properties and range of meanings. Next, we reveal a Markovian logic, akin ...
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作者：Pome, Antonella; Zimmermann, Eckart
作者单位：Heinrich Heine University Dusseldorf
摘要：Humans maintain a stable view of the world by omitting self-generated motion during rapid eye movements, or saccades. An efferent copy of the saccade motor command informs visual processing about the self-produced motion. However, efference copy information has been demonstrated to be disrupted in individuals with high autistic traits. Here, we investigated saccadic omission in participants with high vs. low autistic traits. Participants made saccades to peripheral targets and reported the loc...
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作者：Erickson, Anders W.; Tan, Henry; Hendrikse, Liam D.; Millman, Jake; Thomson, Zachary; Golser, Joseph; Khan, Omar; He, Guanyi; Bach, Kathleen; Mishra, Arpit Suresh; Kopic, Janja; Krsnik, Zeljka; Encha- Razavi, Ferechte; Petrilli, Giulia; Guimiot, Fabien; Silvestri, Evelina; Aldinger, Kimberly A.; Taylor, Michael D.; Millen, Kathleen J.; Haldipur, Parthiv
作者单位：University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Seattle Children's Hospital; Benaroya Research Institute; University of Zagreb; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Robert-Debre - APHP; Institut National de la Sante et de la Recherche Medicale (Inserm); Azienda Ospedaliera San Camillo-Forlanini; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Texas Children's Cancer Center; Baylor College of Medicine; Baylor College of Medicine; Baylor College of Medicine; Baylor College Medical Hospital; Baylor College of Medicine; University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; Hospital for Sick Children (SickKids); University of Toronto; University of Toronto
摘要：The cerebellar ventricular zone (VZ) is the primary source of progenitors that generate cerebellar GABAergic neurons, including Purkinje cells (PCs) and interneurons (INs). This study provides detailed characterization of human cerebellar GABAergic neurogenesis using transcriptomic and histopathological analyses and reveals conserved and unique features compared to rodents. We show that the sequential progression of neurogenesis is conserved and occurs before 8 postconception weeks. Notably, P...
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作者：Kadoya, Taku; Suzuki, Kenta; Terui, Akira
作者单位：National Institute for Environmental Studies - Japan; RIKEN; Yokohama National University; University of North Carolina; University of North Carolina Greensboro
摘要：The resilience of an ecological community informs us how it will respond to future environmental disturbances. However, the concept is rarely tested in the context of predicting biodiversity change, particularly at broad spatial and taxonomic scales. Here, we show that measures of instability derived from the resilience of the current state of community compositions greatly improve the predictability of biodiversity change. We applied energy landscape analysis (ELA) to community compositions o...
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作者：Nishio, Miki; Yamaguchi, Keiko; Otani, Junji; Yuguchi, Katsuya; Kohno, Daisuke; Sasaki, Tsutomu; Kitamura, Tadahiro; Shinohara, Masakazu; Soga, Tomoyoshi; Kawamura, Koichi; Sasaki, Atsuo T.; Oshima, Masashi; Hikasa, Hiroki; Woo, Minna; Sasaki, Takehiko; Nishina, Hiroshi; Nakao, Kazuwa; Maehama, Tomohiko; Suzuki, Akira
作者单位：Kobe University; Gunma University; Kyoto University; Kobe University; Keio University; Keio University; Waseda University; University System of Ohio; University of Cincinnati; Hiroshima University; Jichi Medical University; University of Occupational & Environmental Health - Japan; University of Toronto; University of Toronto; University of Toronto; University Health Network Toronto; Institute of Science Tokyo; Kyoto University; Showa Medical University
摘要：There is currently a global epidemic of obesity and obesity-related diseases such as type 2 diabetes due to decreased physical activity, excessive food intake, and/or genetic predisposition. The Hippo-YAP1 pathway has attracted attention as a potential therapeutic target because YAP1/TAZ activation in murine immature adipocytes in vitro suppresses their differentiation by inhibiting PPAR gamma activity.However, the role of YAP1 activation in mature adipocytes in vivo remains unclear. MOB1, who...
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作者：Ojha, Shashank Kumar; Pal, Pratap; Prokhorenko, Sergei; Husain, Sajid; Ramesh, Maya; Li, Xinyan; Kang, Deokyoung; Meisenheimer, Peter; Schlom, Darrell G.; Stevenson, Paul; Caretta, Lucas; Nahas, Yousra; Han, Yimo; Martin, Lane W.; Bellaiche, Laurent; Eom, Chang-Beom; Ramesh, Ramamoorthy
作者单位：Rice University; Rice University; University of Wisconsin System; University of Wisconsin Madison; University of Arkansas System; University of Arkansas Fayetteville; University of Arkansas System; University of Arkansas Fayetteville; University of California System; University of California Berkeley; Cornell University; Cornell University; Leibniz Association; Leibniz Institut fur Kristallzuchtung (IKZ); Northeastern University; Brown University; Rice University; Rice University; Tel Aviv University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley
摘要：Pattern formation in spin systems with continuous-rotational symmetry (CRS) provides a powerful platform to study emergent complex magnetic phases and topological defects in condensed-matter physics. However, its understanding and correlation with unconventional magnetic order along with high-resolution nanoscale imaging are challenging. Here, we employ scanning nitrogen vacancy (NV) magnetometry to unveil the morphogenesis of spin cycloids at both the local and global scales within a single f...
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作者：Paulson, Abigail L.; Zhang, Lu; Prichard, Ashley M.; Singer, Annabelle C.
作者单位：University System of Georgia; Georgia Institute of Technology; Emory University; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); US Department of Veterans Affairs; Veterans Health Administration (VHA); Atlanta VA Health Care System
摘要：40 Hz sensory stimulation (flicker) has emerged as a new technique to potentially mitigate pathology and improve cognition in mouse models of Alzheimer's disease (AD) pathology. However, it remains unknown how 40 Hz flicker affects neural codes essential for memory. Accordingly, we investigate the effects of 40 Hz flicker on neural representations of experience in the hippocampus of the 5XFAD mouse model of AD by recording 1,000s of neurons during a goal-directed spatial navigation task. We fi...
