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作者：Keais, Graeme L.; Saad-Roy, Chadi M.; Gonzalez-Sqalli, Emmanuel; Powell, Candice N.; Rieseberg, Loren H.; Gawryluk, Ryan M. R.; van den Driessche, P.; Wei, Kevin H. -C.; Loppin, Benjamin; Perlman, Steve J.
作者单位：University of Victoria; University of British Columbia; University of British Columbia; University of California System; University of California Berkeley; University of California System; University of California Berkeley; Ecole Normale Superieure de Lyon (ENS de LYON); Universite Jean Monnet; Universite Lyon 1; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CHU Lyon; CNRS - National Institute for Biology (INSB); University of Victoria; University of British Columbia
摘要：Meiotic drivers are selfish genetic elements that bias their own transmission during meiosis or gamete formation. Due to the fundamental differences between male and female meiosis in animals and plants, meiotic drivers operate through distinct mechanisms in the two sexes: In females, they exploit the asymmetry of meiosis to ensure their inclusion in the egg, whereas in males, they eliminate competing gametes after symmetric meiosis. Meiotic drive is commonly reported in males, where it strong...
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作者：Gonzalez-Trujillo, Juan David; Assis, Jorge; Serrao, Ester; Costello, Mark John; Fragkopoulou, Eliza; Mendoza, Manuel; Araujo, Miguel B.
作者单位：University of Evora; University of Evora; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Nacional de Colombia; Universidade do Algarve; Nord University; Okinawa Institute of Science & Technology Graduate University
摘要：Biogeographic regions arise due to constraints on species ranges, fostering lineage divergence as a result. Yet, convergent evolution means that evolutionary distinct lineages can share similar characteristics when subjected to similar environmental conditions. The ecological convergence of distinct regions has been demonstrated in terrestrial communities, but it remains uncertain if marine systems exhibit similar patterns, given the greater ease of dispersal in the ocean. Using information on...
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作者：Tachiyama, Shoichi; Rosinke, Kyle; Khan, Mohammad F.; Zhou, Xiaotian; Xin, Yue; Botting, Jack M.; Yue, Jian; Roujeinikova, Anna; Hoover, Timothy R.; Liu, Jun
作者单位：Yale University; Yale University; University System of Georgia; University of Georgia; Monash University; Monash University
摘要：Helicobacter pylori has evolved distinct flagellar motility to colonize the human stomach. Rotation of the H. pylori flagella is driven by one of the largest known bacterial flagellar motors. In addition to the core motor components found in Escherichia coli and Salmonella enterica, the flagellar motor in H. pylori possesses many accessories that enable the bacteria to penetrate the gastric mucus layer. Here, we utilize cryoelectron tomography with molecular genetics and biochemical approaches...
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作者：McDonald, Eli Fritz; Kim, Minsoo; Olson, John A.; Meiler, Jens; Plate, Lars
作者单位：Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Leipzig University; Vanderbilt University; Vanderbilt University
摘要：Cystic fibrosis (CF) is a lethal genetic disorder caused by variants in CF transmembrane conductance regulator (CFTR). Many variants are treatable with correctors, which enhance the folding and trafficking of CFTR. However, approximately 3% of persons with CF harbor poorly responsive variants. Here, we used affinity purification mass spectrometry proteomics to profile the protein homeostasis (proteostasis) changes of CFTR variants during correction to assess modulated interactions with protein...
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作者：Cao, Yang; Chen, Yanbo; Liu, Weiwei
作者单位：Wuhan University; Wuhan University; Wuhan University; Wuhan University
摘要：Neural collapse (NC) reveals that the last layer of the network can capture data representations, leading to similar outputs for examples within the same class, while outputs for examples from different classes form a simplex equiangular tight frame (ETF) structure. This phenomenon has garnered significant attention due to its implications on the intrinsic properties of neural networks. Interestingly, we observe a simplex compression phenomenon in NC, where the geometric size of the simplex ET...
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作者：Filsinger, Gabriel T.; Mychack, Aaron; Lyerly, Evan; Henriksen, Camilla; Bartlett, Thomas M.; Kuchwara, Helene; Eitzinger, Simon; Bernhardt, Thomas G.; Walker, Suzanne; Church, George M.; Wannier, Timothy M.
作者单位：Harvard University; Harvard Medical School; Stanford University; Harvard University; University of Copenhagen; State University of New York (SUNY) System; Wadsworth Center; Harvard University; Harvard Medical School; Harvard University; Harvard University
摘要：Genome modification is essential for studying and engineering bacteria, yet making efficient modifications to most species remains challenging. Bacteriophage-encoded single-stranded DNA-annealing proteins (SSAPs) can facilitate efficient genome editing by homologous recombination, but their typically narrow host range limits broad application. Here, we demonstrate that a single library of 227 SSAPs enables efficient genome-editing across six diverse bacteria from three divergent classes: Actin...
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作者：Lizee, Mathieu; Esfandiar, Ali; Panoni, Eva; Mischenko, Artem; Taberna, Pierre-Louis; Simon, Patrice; Bocquet, Lyderic
作者单位：Max Planck Society; Fritz Haber Institute of the Max Planck Society; Universite PSL; Universite Paris Cite; Ecole Normale Superieure (ENS); Sharif University of Technology; University of Manchester; Centre National de la Recherche Scientifique (CNRS); Universite de Toulouse (EPE); Communaute d'universites et etablissements de Toulouse (Comue); CNRS - Institute of Chemistry (INC); Institut National Polytechnique de Toulouse
摘要：Transport of electrons and ions at carbon surfaces immersed in electrolytes is instrumental for a wide variety of membrane processes as well as energy storage in batteries and supercapacitors. Ion transport in a nanoporous electrode strongly depends on its electronic conductance and on the interfacial capacitance with the electrolyte. In this study, we use in-plane impedance spectroscopy to disentangle in-plane ionic and electronic transport on a single crystal graphene transistor covered by a...
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作者：Mukhi, Nitika; Brown, Hannah; Gorenkin, Danylo; Ding, Pingtao; Bentham, Adam R.; Stevenson, Clare E. M.; Jones, Jonathan D. G.; Banfield, Mark J.
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作者：Bontorin, Sebastiano; Centellegher, Simone; Gallotti, Riccardo; Pappalardo, Luca; Lepri, Bruno; Luca, Massimiliano
作者单位：Fondazione Bruno Kessler; University of Trento; Fondazione Bruno Kessler; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienza e Tecnologie dell'Informazione Alessandro Faedo (ISTI-CNR); Scuola Normale Superiore di Pisa
摘要：Predicting human displacements is crucial for addressing various societal challenges, including urban design, traffic congestion, epidemic management, and migration dynamics. While predictive models like deep learning and Markov models offer insights into individual mobility, they often struggle with out-of-routine behaviors. Our study introduces an approach that dynamically integrates individual and collective mobility behaviors, leveraging collective intelligence to enhance prediction accura...
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作者：Danning, Rebecca; Hu, Frank B.; Lin, Xihong
作者单位：Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University
摘要：Disease and behavior subtype identification is of significant interest in biomedical research. However, in many settings, subtype discovery is limited by a lack of robust statistical clustering methods appropriate for binary data. Here, we introduce LACE-UP [latent class analysis ensembled with UMAP (uniform manifold approximation and projection) and PCA (principal components analysis)], an ensemble machine-learning method for clustering multidimensional binary data that does not require presp...
