17期

最新文章

• Molecular organization of central cholinergic synapses AI翻译
  作者：Rosenthal, Justin S.; Zhang, Dean; Yin, Jun; Long, Caixia; Yang, George; Li, Yan; Lu, Zhiyuan; Li, Wei-Ping; Yu, Zhiheng; Li, Jiefu; Yuan, Quan
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Howard Hughes Medical Institute
  摘要：Synapses have undergone significant diversification and adaptation, contributing to the complexity of the central nervous system. Understanding their molecular architecture is essential for deciphering the brain's functional evolution. While nicotinic acetylcholine receptors (nAchRs) are widely distributed across metazoan brains, their associated protein networks remain poorly characterized. Using in vivo proximity labeling, we generated proteomic maps of subunit- specific nAchR interactomes i...
• Start your engines: How migratory fibroblasts respond to and remember mechanical stretch AI翻译
  作者：Weihs, Daphne
  作者单位：Technion Israel Institute of Technology; Ghent University; Ghent University Hospital; Hasselt University; Hasselt University
• The tilt illusion arises from an efficient reallocation of neural coding resources at the contextual boundary AI翻译
  作者：Zhang, Ling-Qi; Mao, Jiang; Aguirre, Geoffrey K.; Stocker, Alan A.
  作者单位：University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine
  摘要：The tilt illusion-a bias in the perceived orientation of a center stimulus induced by an oriented surround-illustrates how context shapes visual perception. Although extensively studied for decades, we still lack a comprehensive account of the illusion that connects its behavioral and neural characteristics. Here, we demonstrate that the tilt illusion originates from dynamic changes in neural coding precision induced by the surround context. We simultaneously obtained psychophysical and functi...
• tRNA selectivity during ribosome-associated quality control regulates the critical sterility-inducing temperature in two-line hybrid rice (vol 122, e2417526122, 2025) AI翻译
  作者：Zhou, Can; Liu, Chunyan; Yan, Bin; Sun, Jing; Li, Shengdong; Li, Ji; Wang, Jia; Huang, Xiahe; Yan, Wei; Yang, Shuying; Fu, Chenjian; Qin, Peng; Fu, Xingxue; Zhao, Xinghui; Wu, Yaxian; Song, Xianwei; Wang, Yingchun; Qian, Wenfeng; Yang, Yuanzhu; Cao, Xiaofeng
• An algorithmic constraint at the transition to complex life AI翻译
  作者：Ferrada, Evandro
  作者单位：Universidad de Valparaiso; Universidad de Valparaiso
• A simple method for mapping the location of cross-β-forming regions within protein domains of low sequence complexity AI翻译
  作者：Gu, Jinge; Zhou, Xiaoming; Sutherland, Lillian; Liszczak, Glen; Mcknight, Steven L.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; Westlake University
  摘要：Protein domains of low sequence complexity are unable to fold into stable, three-dimensional structures. In test tube studies, these unusual polypeptide regions can self-associate in a manner causing phase separation from aqueous solution. This form of protein:protein interaction has been implicated in numerous examples of dynamic morphological organization within eukaryotic cells. In several cases, the basis for low complexity domain (LCD) self-association and phase separation has been traced...
• Structure in conversation: Evidence for the vocabulary, semantics, and syntax of prosody AI翻译
  作者：Matalon, Nadav; Weinreb, Eyal; Freche, Dominik; Volk, Erez; Biron, Tirza; Moses, Elisha; Biron, David
  作者单位：Weizmann Institute of Science; Hebrew University of Jerusalem; Weizmann Institute of Science; University of Chicago; University of Chicago
  摘要：Prosody, the musical facet of speech, is pivotal in human communication, and its structure and meaning remain subjects of ongoing research. In this study, we introduce a data-driven model for English prosody, based on large-scale analysis of spontaneous conversations. As a first step, we identify approximately 200 discernible prosodic patterns-which we view as building blocks of the prosodic vocabulary-and outline their properties and range of meanings. Next, we reveal a Markovian logic, akin ...
• Evolutionary feedbacks for Drosophila aggression revealed through experimental evolution AI翻译
  作者：Girardeau, Anna R.; Enochs, Grace E.; Saltz, Julia B.
  作者单位：Rice University
  摘要：Evolutionary feedbacks occur when evolution in one generation alters the environment experienced by subsequent generations and are an expected result of indirect genetic effects (IGEs). Hypotheses abound for the role of evolutionary feedbacks in climate change, agriculture, community dynamics, population persistence, social interactions, the genetic basis of evolution, and more, but evolutionary feedbacks have rarely been directly measured experimentally, leaving open questions about how feedb...
• Unusual magnetotransport in twisted bilayer graphene from strain-induced open Fermi surfaces (vol 120, e2307151120, 2023) AI翻译
  作者：Wang, Xiaoyu; Finney, Joe; Sharpe, Aaron L.; Rodenbach, Linsey K.; Hsueh, Connie L.; Watanabe, Kenji; Taniguchi, Takashi; Kastner, M. A.; Vafek, Oskar; Goldhaber-Gordon, David
• Rab32 regulates Golgi structure and cell migration through Protein Kinase A-mediated phosphorylation of Optineurin AI翻译
  作者：Johnson, Katherine M.; Marley, Maxwell G.; Drizyte -Miller, Kristina; Chen, Jing; Cao, Hong; Mostafa, Nourhan; Schott, Micah B.; Mcniven, Mark A.; Razidlo, Gina L.
  作者单位：Mayo Clinic; Mayo Clinic; Mayo Clinic; University of Nebraska System; University of Nebraska Medical Center
  摘要：Rab32 is a small GTPase and molecular switch implicated in vesicular trafficking. Rab32 is also an A-Kinase Anchoring Protein (AKAP), which anchors cAMP-dependent Protein Kinase (PKA) to specific subcellular locations and specifies PKA phosphorylation of nearby substrates. Surprisingly, we found that a form of Rab32 deficient in PKA binding (Rab32 L188P) relocalized away from the Golgi apparatus and induced a marked disruption in Golgi organization, assembly, and dynamics. Although Rab32 L188P...