作者：Compton, Austin; Sharma, Atashi; Hempel, Melanie; Aryan, Azadeh; Biedler, James K.; Potters, Mark B.; Chandrasegaran, Karthikeyan; Vinauger, Clement; Tu, Zhijian
作者单位：Oxford Nanopore Technologies; Jackson Laboratory; Virginia Polytechnic Institute & State University; Virginia Polytechnic Institute & State University; University of California System; University of California Riverside
摘要：Diverse genetic strategies are being pursued to control mosquito-borne infectious diseases. These strategies often rely on the release of nonbiting males to either reduce the target mosquito population or render them resistant to pathogens. Male-only releases are important as any contaminating females can bite and potentially transmit pathogens. Despite significant efforts, it remains a major bottleneck to reliably and efficiently separate males from females, especially when nontransgenic male...
作者：Duy, Phan Q.; Kiziltug, Emre; Greenberg, Ana B. W.; Mehta, Neel H.; Hao, Le T.; Fortes, Carla; Mullany, Susan; Fan, Baojian; Manichaikul, Ani; Teich, Andrew F.; Chan, Diane; Alper, Seth L.; Hyman, Bradley T.; Arnold, Steven E.; Mckhann, Guy M.; Frosch, Matthew P.; Kahle, Kristopher T.
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Virginia; Columbia University; Columbia University; Columbia University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Columbia University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：We have generated a single-cell RNA sequencing atlas of peripheral blood and ventricular CSF in idiopathic normal pressure hydrocephalus (iNPH) patients totaling 140,207 single-cell transcriptomes. We found proinflammatory alterations in peripheral blood and CSF monocytes in iNPH patients with lower baseline cognitive function. We also identified CSF cell populations likely representing periventricular sloughing of degenerating neuroglial cells. Our findings suggest possible immune dysregulati...
