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作者：Gonzalo, Adrian; Nayak, Aditya; Bomblies, Kirsten
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：During meiosis, the correct pairing, synapsis, and recombination of homologous chromosome pairs is critical for fertility of sexual eukaryotes. These processes are challenged in polyploids, which possess additional copies of each chromosome. Polyploidy thus provides a unique context to study how evolution can modify meiotic programs in response to challenges. We previously observed that in newly formed (neo-)polyploids of Arabidopsis arenosa, synapsis defects precede chromosomes associating in...
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作者：Hall, Matthew E. K.; Solomon, Brittany C.; Voelkel, Jan G.; Stagnaro, Michael N.; Chu, James Y.; Willer, Robb
作者单位：University of Notre Dame; University of Notre Dame; Cornell University; Massachusetts Institute of Technology (MIT); Columbia University; Stanford University
摘要：Recent research has identified several effective strategies for reducing Americans' animosity toward supporters of opposing political parties. However, whether these strategies can durably reduce partisan animosity in a scalable manner and in everyday life remains unclear. We bridge the gap between prior research and useful application by assessing whether exposure to multiple, scalable treatments that portray inparty and outparty members interacting positively, receiving accurate information ...
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作者：Goren, Naama; Pandurangan, Perumal; Eisenberg-Domovich, Yael; Yochelis, Shira; Keren, Nir; Ansermet, Jean-Philippe; Naaman, Ron; Livnah, Oded; Ashkenasy, Nurit; Paltiel, Yossi
作者单位：Hebrew University of Jerusalem; Ben-Gurion University of the Negev; Hebrew University of Jerusalem; Hebrew University of Jerusalem; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Weizmann Institute of Science; Council of Scientific & Industrial Research (CSIR) - India; CSIR - Institute of Minerals & Materials Technology (IMMT)
摘要：Proton transport plays a fundamental role in many biological and chemical systems. In life, proton transport is crucial for biochemical and physiological functions. It is usually accepted that the main mechanism of proton transfer is a result of hopping between neighboring water molecules and amino acid side chains. It was recently suggested that the proton transfer can be simultaneously coupled with electron transfer. As life is homochiral, proton transfer in biology is occurring in a chiral ...
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作者：Lin, Kuan-Yu; Huang, Ying-Wen; Hou, Liang-Yu; Chen, Hsin-Chuan; Wu, Yu; Chen, I-Hsuan; Huang, Ying-Ping; Lee, Shu-Chuan; Hu, Chung-Chi; Tsai, Ching-Hsiu; Hsu, Yau-Heiu; Lin, Na-Sheng
作者单位：Academia Sinica - Taiwan; National Chung Hsing University; National Chung Hsing University
摘要：Diverse single-stranded RNA viruses employ different host cellular organelles or membrane systems to compartmentalize their replication intermediates and proviral factors, ensuring robust replication. Replication of Bamboo mosaic virus (BaMV), an Alphaflexiviridae family, is tightly associated with chloroplasts and dynamic cytosolic viral replication complex (VRC) clusters. BaMV VRC clusters comprise double-stranded viral RNA, BaMV replicase (RepBaMV), and mitochondrial outer membrane protein,...
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作者：Hand, Suzanne J.; Wilson, Laura A. B.; Lopez-Aguirre, Camilo; Houssaye, Alexandra; Archer, Michael; Bevitt, Joseph J.; Evans, Alistair R.; Halim, Amalia Y.; Hung, Tzong; Rich, Thomas H.; Vickers-Rich, Patricia; Beck, Robin M. D.
作者单位：University of New South Wales Sydney; Australian National University; Australian National University; University of Toronto; University Toronto Scarborough; Universidad de La Salle; Universidad Industrial de Santander; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); Australian Nuclear Science & Technology Organisation; Monash University; University of New South Wales Sydney; University of New South Wales Sydney; Monash University; University of Salford
摘要：The platypus and four echidna species are the only living egg-laying mammals and the sole extant representatives of Order Monotremata. The platypus and echidnas are very disparate both morphologically and ecologically: The platypus is a specialized semiaquatic burrowing form that forages for freshwater invertebrates, whereas echidnas are fully terrestrial and adapted for feeding on social insects and earthworms. It has been proposed that echidnas evolved from a semiaquatic, platypus-like ances...
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作者：Ou, Haohong; Yang, Jingtao; Wang, Honglong; Kang, Nuoyao; Li, Shumin; Chen, Yuting; Peng, Zihao; Xiang, Xianzhe; Engel, Michael S.; Winterton, Shaun L.; Ren, Dong; Yang, Qiang; Shi, Chaofan
作者单位：Sun Yat Sen University; Guangzhou University; American Museum of Natural History (AMNH); California Department of Food & Agriculture; Capital Normal University
摘要：The form and change of animal biogeography reflects the long-term interplay between organisms and their environment, involving physiological limitation, dispersal capability, and adaptive evolution versus plate tectonics, global climatic shifts, and changing landscapes. This is especially manifest for lineages with extended geological histories, which, therefore, evokes questions as to the associated processes producing such patterns. Insects, as the earliest flying animals, have exceptional a...
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作者：Peddada, Nagesh; Zhong, Xue; Yin, Yan; Lazaro, Danielle Renee; Wang, Jianhui; Lyon, Stephen; Choi, Jin Huk; Bai, Xiao-Chen; Moresco, Eva Marie Y.; Beutler, Bruce
作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
摘要：The protein midnolin (MIDN) augments proteasome activity in lymphocytes and dramatically facilitates the survival and proliferation of B-lymphoid malignancies. MIDN binds both to proteasomes and to substrates, but the mode of interaction with the proteasome is unknown, and the mechanism by which MIDN facilitates substrate degradation in a ubiquitin-independent manner is incompletely understood. Here, we present cryoelectron microscopy (cryo-EM) structures of the substrate-engaged, MIDN-bound h...
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作者：Shoemaker, Kevin T.; Loope, Kevin J.
作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; Virginia Polytechnic Institute & State University
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作者：Bhattacharyya, Srijan; Sayer, Thomas; Montoya-Castillo, Andres
作者单位：University of Colorado System; University of Colorado Boulder; Durham University
摘要：Predicting the exact many-body quantum dynamics of polarons in materials with strong carrier-phonon interactions presents a fundamental challenge, often necessitating one to adopt approximations that sacrifice the ability to predict the transition from nonequilibrium relaxation to thermodynamic equilibrium. Here, we exploit a recent breakthrough that generalizes the concept of memory beyond its conventional temporal meaning to also encompass space. Specifically, we leverage our finding that th...
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作者：Lu, Yuyang; Gao, Jia; Xie, Ruo - Chen; Su, Hua; Zhang, Yaoyao; Wang, Wei
作者单位：Nanjing University; Nanjing University of Chinese Medicine
摘要：Many phenotypic traits, such as fermentation activity, have been shown to be instable due to stochastic gene expression and environmental influence. While previous studies only have obtained understanding at the level of the microbial community, the fate of extraordinary traits of an individual through generations of reproduction has yet to be adequately investigated. This work uses the lactic acid bacteri Lactiplantibacillus plantarum as a research model to study the activity inheritance betw...
