Single- cell elderly blood-CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus
成果类型：
Article
署名作者：
Duy, Phan Q.; Kiziltug, Emre; Greenberg, Ana B. W.; Mehta, Neel H.; Hao, Le T.; Fortes, Carla; Mullany, Susan; Fan, Baojian; Manichaikul, Ani; Teich, Andrew F.; Chan, Diane; Alper, Seth L.; Hyman, Bradley T.; Arnold, Steven E.; Mckhann, Guy M.; Frosch, Matthew P.; Kahle, Kristopher T.
署名单位：
Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of Virginia; Columbia University; Columbia University; Columbia University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Columbia University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
刊物名称：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN/ISSBN：
0027-15281
DOI：
10.1073/pnas.2412159122
发表日期：
2025-05-05
关键词：
摘要：
We have generated a single-cell RNA sequencing atlas of peripheral blood and ventricular CSF in idiopathic normal pressure hydrocephalus (iNPH) patients totaling 140,207 single-cell transcriptomes. We found proinflammatory alterations in peripheral blood and CSF monocytes in iNPH patients with lower baseline cognitive function. We also identified CSF cell populations likely representing periventricular sloughing of degenerating neuroglial cells. Our findings suggest possible immune dysregulation in the blood and CSF of iNPH patients.