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作者：Diering, Graham H.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
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作者：Katzenberger, Anja; Levermann, Anders
作者单位：Potsdam Institut fur Klimafolgenforschung; University of Potsdam; Columbia University
摘要：Within Earth's climate system, the ocean, cryosphere, and vegetation exhibit hysteresis behavior such that their state depends on their past and not merely on their current boundary conditions. The atmosphere's fast mixing time scales were thought to inhibit the necessary memory effect for such multistability. Here, we show that moisture accumulation within the atmospheric column generates hysteresis in monsoon circulation independent of oceanic heat storage and yields two stable atmospheric s...
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作者：Singh, Ashish K.; Ainciburu, Marina; Wynne, Kieran; Bhat, Sajad A.; Blanco, Alfonso; Tzani, Ioanna; Akiba, Yasutada; Lalor, Stephen J.; Kaunitz, Jonathan; Bourke, Billy; Kelly, Vincent P.; Doherty, Glen A.; Zerbe, Christa S.; Clarke, Colin; Hussey, Seamus; Knaus, Ulla G.
作者单位：University College Dublin; University College Dublin; University College Dublin; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Greater Los Angeles Healthcare System; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; National Children's Research Centre (NCRC); Trinity College Dublin; University College Dublin; Saint Vincent's University Hospital; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); University College Dublin; Royal College of Surgeons - Ireland
摘要：Infiltrating neutrophils are key effector cells in inflammatory bowel disease (IBD) while providing antimicrobial defense and tissue restitution in the intestine. The complexity of neutrophil functions in local environments underscores our limited understanding of how their adaptation in tissues influences disease progression. Here, we demonstrate that neutrophils recruited in murine colitis and infection models, idiopathic IBD, and gramming, resulting in the emergence of neutrophil population...
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作者：Rose, Jeffrey P.; Li, Bing; Koehler, Margaret J. Sporck-; Stacy, Elizabeth A.; Wood, Kenneth R.; Lemmon, Emily Moriarty; Lemmon, Alan R.; Ane, Cecile; Sytsma, Kenneth J.; Givnish, Thomas J.
作者单位：University of Wisconsin System; University of Wisconsin Madison; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; State University System of Florida; Florida State University; State University System of Florida; Florida State University; University of Wisconsin System; University of Wisconsin Madison
摘要：Hawaiian lobeliads exhibit extensive adaptive radiations and are considered the largest plant clade (143 species) endemic to any oceanic archipelago. Rapid insular radiations are prone to reticulate evolution, yet detecting hybridization is often limited by inadequate sampling of taxa or independent loci. We analyzed 633 nuclear loci (including tetraploid duplications) and whole plastomes for 89% of extant species to derive phylogenies for the Hawaiian lobeliads. Nuclear data provide strong su...
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作者：Jung, Yaelan; Dilks, Daniel D.
作者单位：Emory University
摘要：Representing the locations of places so that we can use them as landmarks is critical to our ability to navigate through large- scale spaces-a process referred to as map- based navigation. While many neuroimaging studies in adults have revealed that this ability involves the retrosplenial complex (RSC)-a scene- selective region in the medial parietal cortex-nothing is known about how this cortical system develops. So, does it develop only late in childhood, as generally assumed from some behav...
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作者：Rossen, Nathan D.; Touhara, Kouki K.; Castro, Joel; Harrington, Andrea M.; Caraballo, Sonia Garcia; Deng, Fei; Li, Yulong; Brierley, Stuart M.; Julius, David
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; South Australian Health & Medical Research Institute (SAHMRI); University of Adelaide; Peking University; Peking University
摘要：Sensory enteroendocrine cells in the intestinal epithelium detect and relay information about the luminal environment to other cells within and outside the gut. Serotonergic enterochromaffin (EC) cells are a subset of enteroendocrine cells that detect noxious stimuli within the gut lumen, such as chemical irritants and microbial byproducts, and transduce this information to sensory nerve fibers to elicit defensive responses such as nausea and visceral pain. While much has recently been learned...
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作者：Zeng, Haolin; Ross, Kenneth G.; Sasaki, Takao
作者单位：University System of Georgia; University of Georgia; University System of Georgia; University of Georgia; University of Rochester
摘要：Genes and the environment jointly shape individual traits, but the influence of indirect genetic effects (IGEs), arising from the genetic composition of interacting conspecific individuals, is often ignored or underemphasized. Moreover, because of practical challenges in characterizing IGEs, empirical research has fallen behind theoretical advancement. The fire ant Solenopsis invicta offers a uniquely suitable study system due to its distinct colony- level phenotypic variation (monogyne and po...
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作者：Miles, Jillian; Combemale, Christophe; Karplus, Valerie J.; Pistorius, P. Chris
作者单位：Carnegie Mellon University; Carnegie Mellon University
摘要：Global efforts to mitigate climate change are increasing pressure on heavy manufacturing industries to decarbonize production. The iron and steel industry is responsible for 7% of CO2 emissions globally (2% in the United States) and is often a major employer in the regions where iron and steel is produced. Understanding the future prospects for workers in regions with high CO2 emitting industries-including impacts of phasing out or evolving such industries-will be critical for informing region...
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作者：Wang, Edric X.; Ushakov, Sergey, V; Wang, Ligen; Matteucci, Jared; Xu, Hongwu; Opila, Elizabeth J.; Hong, Qi-Jun; Navrotsky, Alexandra
作者单位：Arizona State University; Arizona State University-Tempe; University of Illinois System; University of Illinois Urbana-Champaign; Arizona State University; Arizona State University-Tempe; University of Virginia
摘要：Rare earth oxyphosphates represent a large family of compounds with the general formula (RE2O3)x(REPO4), where RE refers to lanthanides and yttrium. At least four known stoichiometries have been established, each with distinct structures. These compounds have potential applications as refractory coatings, catalysts, and magnetic materials. We modeled the stability of RE3PO7 [RE3(PO4)O3] with respect to rare earth sesquioxides (RE2O3) and orthophosphates (REPO4) using DFT computations with the ...
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作者：Wang, Hong - Yin; Rumin, Alissa; Doktorova, Milka; Sputay, Daryna; Chan, Sze Ham; Wehman, Ann M.; Levental, Kandice R.; Levental, Ilya
作者单位：University of Virginia; University of Denver; Stockholm University; Texas A&M University System; Texas A&M University College Station
摘要：Membrane blebs have important roles in cell migration, apoptosis, and intercellular communication through extracellular vesicles (EVs). While plasma membranes (PM) typically maintain phosphatidylserine (PS) on their cytoplasmic leaflet, most blebs have PS exposed on their outer leaflet, revealing that loss of steady-state lipid asymmetry often accompanies PM blebbing. How these changes in PM lipid organization regulate membrane properties and affect bleb formation remains unknown. We confirmed...
