19期

最新文章

• Incorporation of polylactic acid microplastics into the carbon cycle as a carbon source to remodel the endogenous metabolism of the gut AI翻译
  作者：Bao, Lin; Cui, Xuejing; Zeng, Tao; Liu, Guanyu; Lai, Wenjia; Zhao, Hao; Gao, Fene; Wu, Junguang; Leong, Kam W.; Chen, Chunying
  作者单位：Chinese Academy of Sciences; Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, CAS; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Medical Sciences - Peking Union Medical College; Sun Yat Sen University; Chinese Academy of Sciences; National Center for Nanoscience & Technology, CAS; Columbia University
  摘要：Biodegradable polylactic acid (PLA) plastics have been praised as an effective solution to the global pollution caused by petroleum-based plastics, and their widespread use in food packaging and disposable tableware has resulted in increased oral exposure to PLA microplastics (PLA-MPs). Despite their eco-friendly and biodegradable reputation, the in vivo behaviors of PLA-MPs concerning fermentation, carbon cycle, and adverse effects remain unknown. Here, we showed that gut microbiota from the ...
• The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes AI翻译
  作者：Jauregi-Miguel, Amaia; Soderholm, Simon; Weiss, Tamina; Nordin, Anna; Ghezzi, Valeria; Brutsch, Salome M.; Pagella, Pierfrancesco; van de Grift, Yorick; Zambanini, Gianluca; Ulisse, Jacopo; Mattia, Alessandro; Deviatiiarov, Ruslan; Faustini, Elena; Moparthi, Lavanya; Zhong, Wenjing; Bjornsson, Bergthor; Sandstrom, Per; Lundqvist, Erik; Lottersberger, Francisca; Koch, Stefan; Moor, Andreas E.; Sun, Xiao-Feng; von Castelmur, Eleonore; Sheng, Guojun; Cantu, Claudio
  作者单位：Linkoping University; Linkoping University; Linkoping University; Linkoping University; Kazan Federal University; Russian Academy of Medical Sciences; Endocrinology Research Centre; Juntendo University; Linkoping University; Linkoping University; Linkoping University; Linkoping University; Linkoping University; Linkoping University; Kumamoto University; Max Planck Society
  摘要：Wnt signaling orchestrates gene expression in a plethora of processes during development and adult cell homeostasis via the action of nuclear beta-catenin. Yet, little is known about how beta-catenin generates context-specific transcriptional outcomes. Understanding this will reveal how aberrant Wnt/beta-catenin signaling causes neoplasia specifically of the colorectal epithelium. We have previously identified the transcription factor TBX3 as a tissue-specific component of the Wnt/beta-catenin...
• Impact of Mg2+and pH on amorphous calcium carbonate nanoparticle formation: Implications for biomineralization and ocean acidification AI翻译
  作者：Kuhrts, Lucas; Shaked, Hadar; Sklar, Johanna; Prudnikov, Elena; Prevost, Sylvain; Manna, Gouranga; Sztucki, Michael; Katsman, Alexander; Pokroy, Boaz
  作者单位：Technion Israel Institute of Technology; Institut Laue-Langevin (ILL); European Synchrotron Radiation Facility (ESRF)
  摘要：Crystallization by amorphous calcium carbonate (ACC) particle attachment (CPA) is a prevalent biomineralization mechanism among calcifying organisms. A narrow, controlled size distribution of ACC nanoparticles is essential for macroscopic crystal formation via CPA. Using in situ synchrotron small-angle X-ray scattering, we demonstrate that synthetic magnesium-stabilized ACC (Mg-ACC) nanoparticles form with an exceptionally narrow size distribution near the spinodal line during liquid-liquid ph...
• Lateral jaw motion in fish expands the functional repertoire of vertebrates and underpins the success of a dominant herbivore lineage AI翻译
  作者：Mihalitsis, Michalis; Yamhure-Ramirez, Denise; Beil, Maelan H.; Chan, Howan; Cole, Nathan J.; Luenenborg, Ava; Paglione, Isabella; Petri, Hallee; Shum, Nicole C.; Wainwright, Dylan K.; Zheng, Bryson; Wainwright, Peter C.
  作者单位：University of California System; University of California Davis; University of Guam; Rice University; Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：The primary function of the vertebrate jaw is the dorsoventral movement that occurs during opening and closing. Yet, several lineages have evolved the ability to move their jaws laterally, enabling major innovations, like chewing. While lateral jaw motions are primarily known in tetrapods, here, we show that an ecologically dominant lineage of reef fishes (Zanclidae and Acanthuridae) has evolved the ability to laterally rotate their jaws during feeding. This unique function substantially expan...
• Structure and nucleic acid interactions of the SΔ60 domain of the hepatitis delta virus small antigen AI翻译
  作者：Yang, Yang; Delcourte, Loic; van Belleghem, Carolanne; Fonte, Simone; Gerard, Kassandra; Baconnais, Sonia; Callon, Morgane; Le Cam, Eric; Fogeron, Marie-Laure; Levrero, Massimo; Faivre-Moskalenko, Cendrine; Bockmann, Anja; Lecoq, Lauriane
  作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Ecole Normale Superieure de Lyon (ENS de LYON); CHU Lyon; Universite Claude Bernard Lyon 1
  摘要：Infection with hepatitis delta virus (HDV) causes the most severe form of viral hepatitis, affecting more than 15 million people worldwide. HDV is a small RNA satellite virus of the hepatitis B virus (HBV) that relies on the HBV envelope for viral particle assembly. The only specific HDV component is the ribonucleoprotein (RNP), which consists of viral RNA (vRNA) associated with the small (S) and large (L) delta antigens (HDAg). While the structure of the HDAg N-terminal assembly domain is kno...
• Persistent pseudopod splitting is an effective chemotaxis strategy in shallow gradients AI翻译
  作者：Alonso, Albert; Kirkegaard, Julius B.; Endres, Robert G.
  作者单位：University of Copenhagen; Niels Bohr Institute; University of Copenhagen; Imperial College London; Imperial College London
  摘要：Single-cell organisms and various cell types use a range of motility modes when following a chemical gradient, but it is unclear which mode is best suited for different gradients. Here, we model directional decision-making in chemotactic amoeboid cells as a stimulus-dependent actin recruitment contest. Pseudopods extending from the cell body compete for a finite actin pool to push the cell in their direction until one pseudopod wins and determines the direction of movement. Our minimal model p...
• Unconventional secretion of PARK7 requires lysosomal delivery via chaperone- mediated autophagy and specialized SNARE complex AI翻译
  作者：Dash, Biplab Kumar; Urano, Yasuomi; Mita, Yuichiro; Ashida, Yuki; Hirose, Ryoma; Noguchi, Noriko
  作者单位：Doshisha University; Doshisha University
  摘要：PARK7/DJ-1, a redox-sensitive protein implicated in neurodegeneration, cancer, and inflammation, exhibits increased secretion under stress. We previously demonstrated that, as a leaderless protein, PARK7 relies on an unconventional autophagy pathway for stress-induced secretion. The current study delves deeper into the mechanisms governing PARK7 secretion under oxidative stress triggered by the neurotoxin 6-hydroxydopamine (6-OHDA). Here, we revealed that 6-OHDA-induced autophagic flux is crit...
• VCP's nuclear journey: Initiated by interacting with KPNB1 to repair DNA damage AI翻译
  作者：Xing, Zhichao; Cai, Xiaoying; He, Ting; Li, Peiheng; He, Jun; Qiu, Yuxuan; Li, Na; Mi, Li; Li, Ruixi; Zhu, Jingqiang; Li, Zhihui; Su, Anping; Ye, Haoyu; Wu, Wenshuang
  作者单位：Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Sichuan University; Westlake University
  摘要：DNA damage repair (DDR) is essential for cancer cell survival and treatment resistance, making it a critical target for tumor therapy. The eukaryotic AAA+ adenosine triphosphatase valosin-containing protein (VCP), which is transported from the cytoplasm into the nucleus, plays a critical role in the DDR process. However, the nuclear translocation and molecular mechanism of VCP for DDR remain elusive. Here, we define VCP as a KPNB1 interacting protein through a combination of chemical and immun...
• Architecture of Pseudomonas aeruginosa glutamyl-tRNA synthetase defines a subfamily of dimeric class Ib aminoacyl-tRNA synthetases AI翻译
  作者：Fenwick, Michael K.; Mayclin, Stephen J.; Seibold, Steve; DeRocher, Amy E.; Subramanian, Sandhya; Phan, Isabelle Q.; Dranow, David M.; Lorimer, Donald D.; Abramov, Ariel B.; Choi, Ryan; Hewitt, Stephen Nakazawa; Edwards, Thomas E.; Bullard, James M.; Battaile, Kevin P.; Wower, Iwona K.; Soe, Aimee C.; Tsutakawa, Susan E.; Lovell, Scott; Myler, Peter J.; Wower, Jacek; Staker, Bart L.
  作者单位：Seattle Children's Hospital; Seattle Children's Hospital; University of Kansas; University of Texas System; University of Texas Rio Grande Valley; Auburn University System; Auburn University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
  摘要：The aminoacyl-tRNA synthetases (AaRSs) are an ancient family of structurally diverse enzymes that are divided into two major classes. The functionalities of most AaRSs are inextricably linked to their oligomeric states. While GluRSs were previously classified as monomers, the current investigation reveals that the form expressed in Pseudomonas aeruginosa is a rotationally pseudosymmetrical homodimer featuring intersubunit tRNA binding sites. Both subunits display a highly bent, pipe strap conf...
• Molecular insights into de novo small- molecule recognition by an intron RNA structure AI翻译
  作者：Liu, Tianshuo; Xu, Ling; Chung, Kevin; Sisto, Luke J.; Hwang, Jimin; Zhang, Chengxin; Van Zandt, Michael C.; Pyle, Anna Marie
  作者单位：Yale University; Howard Hughes Medical Institute; Yale University; Yale University
  摘要：Despite the promise of vastly expanding the druggable genome, rational design of RNA-targeting ligands remains challenging as it requires the rapid identification of hits and visualization of the resulting cocomplexes for guiding optimization. Here, we leveraged high-throughput screening, medicinal chemistry, and structural biology to identify a de novo splicing inhibitor against a large and highly folded fungal group I intron. High-resolution cryoEM structures of the intron in different ligan...