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作者：Compton, Zachary T.; Vincze, Orsolya; Mellon, Walker; Tollis, Marc; Abegglen, Lisa; Schiffman, Joshua D.; Giraudeau, Mathieu; Boddy, Amy M.; Maley, Carlo C.
作者单位：Arizona State University; Arizona State University-Tempe; University of Arizona; University of Arizona; HUN-REN; HUN-REN Centre for Ecological Research; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Northern Arizona University; Utah System of Higher Education; University of Utah; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute; University of California System; University of California Santa Barbara; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe
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作者：Du, Pengyu; Tang, Kai; Chen, Xi; Xin, Ying; Hu, Bin; Meng, Jianfeng; Hu, Guanshuo; Zhang, Cunyu; Li, Keming; Tan, Youhua
作者单位：Hong Kong Polytechnic University; Hong Kong Polytechnic University; Hong Kong Polytechnic University; Guizhou University of Traditional Chinese Medicine
摘要：Resistance to chemotherapeutics is one major challenge to clinical effectiveness of cancer treatment and is primarily interpreted by various biochemical mechanisms. This study establishes an inverse correlation between tumor cell contractility and chemosensitivity. In both clinical biopsies and cancer cell lines, high/low actomyosin- mediated contractile force attenuates/enhances the vulnerability to chemotherapy, which depends on intercellular force propagation. Cell-cell interaction force ac...
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作者：Kelu, Jeffrey J.; Hughes, Simon M.
作者单位：University of London; King's College London
摘要：How central and peripheral circadian clocks regulate protein metabolism and affect tissue mass homeostasis has been unclear. Circadian shifts in the balance between anabolism and catabolism control muscle growth rate in young zebrafish independent of behavioral cycles. Here, we show that the ubiquitin-proteasome system (UPS) and autophagy, which mediate muscle protein degradation, are each upregulated at night under the control of the muscle peripheral clock. Perturbation of the muscle transcr...
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作者：Zhao, Guo - Jun; Han, So Yun; Li, Yajuan; Yuan, Dongqiang; Qin, Shuo; Li, Yuhan; Jang, Hongje; Chen, Li - Jing; Wei, Tong - You Wade; He, Ming; Li, Yi - Shun; Chen, Zhen Bouman; Shi, Lingyan; Chien, Shu; Shyy, John Y- J.
作者单位：Zhengzhou University; University of California System; University of California San Diego; University of California System; University of California San Diego; City of Hope; Beckman Research Institute of City of Hope
摘要：Atheroprone flow-increased glycolysis in vascular endothelial cells (ECs) is pivotal in is a major m6A methyltransferase for RNA N6- mehtyladenosine (m6A) modifications to regulate epitranscriptome and cellular functions. With the atheroprone flow upreguin atheroprone flow-induced glycolysis in ECs in vitro and in vivo. Compared to pulflow) increases METTL3 expression to enhance the m6A modifications of mRNAs encoding HK1, PFKFB3, and GCKR, which are rate- limiting enzymes of glycolysis. while...
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作者：Srinivasan, Durga J.; Kapgal, Vijayakumar; Morris, Richard G. M.; Chattarji, Sumantra
作者单位：Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); University of Edinburgh; University of Edinburgh; University of Edinburgh
摘要：Establishing a dominance hierarchy in social organisms is important for access to resources. Stress has been proposed as a major factor influencing an animal's likely position in a social hierarchy. Although individual differences in vulnerability to stress are increasingly recognized, how social hierarchy affects vulnerability remains relatively understudied. Here, we examined how the social dominance status of adult male Sprague-Dawley rats influences their response to stress in interactions...
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作者：Matsu-ura, Toru; Nasu, Atsunori; Lee, Suengwon; Yoshida, Naoko; Matsuura, Kaoru; Yasuda, Masaharu; Nakamura, Kae; Hong, Christian I.; Tsuta, Koji
作者单位：Kansai Medical University; University System of Ohio; University of Cincinnati; Kansai Medical University; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center
摘要：Circadian regulation of the cell cycle progression generates a diurnal supply of newborn cells to replace those lost in organs and tissues. In this study, we analyzed circadian time-dependent changes in cell types within the mouse tongue epithelium. Using single-cell RNA sequencing, we observed circadian time-dependent changes in the populations of stem/progenitor cells and the differentiated cells in mice tongues. Notably, we observed time-dependent changes in the type II taste cell populatio...
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作者：Cai, Tianlong; Wen, Zhixin; Jiang, Zhongguan; Zhen, Ying
作者单位：Westlake Laboratory; Westlake University; Westlake University; Westlake University; Chinese Academy of Sciences; Institute of Zoology, CAS; Anhui University
摘要：The latitudinal diversity gradient (LDG) is the most notable global biodiversity pattern, but its underlying mechanisms remain unresolved. The evolutionary speed hypothesis (ESH) posits that molecular rates play a crucial role in shaping the LDG, suggesting that higher temperatures accelerate molecular rates, thereby facilitating rapid speciation and accumulation of biodiversity in the tropics. However, whether ESH can explain the LDG across diverse taxonomic groups remains debated, and system...
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作者：Jiang, Min; Qin, Yushu; Wang, Yuanhong; Huang, Ying; Peng, Xinhua; Budker, Dmitry
作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Hefei National Laboratory; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Johannes Gutenberg University of Mainz; University of California System; University of California Berkeley
摘要：The use of atoms, molecules, and free electrons in quantum amplifiers has greatly advanced precision measurements, paving the way for the development of extremely-low-noise quantum devices such as masers and lasers. Here, we investigate the signal amplification of interacting spins and observe the amplification of magnetic fields using mixtures of interacting alkali-metal and noble gases. In contrast to noninteracting systems used as amplifiers, we demonstrate that interactions resulting from ...
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作者：Wang, Haiyan; Wang, Yanbing
作者单位：Beijing University of Chinese Medicine; Boston University
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作者：Jiang, Timothy; Krayenhoff, E. Scott; Martilli, Alberto; Nazarian, Negin; Stone Jr, Brian; Voogt, James A.
作者单位：University of Guelph; United States Department of Energy (DOE); Pacific Northwest National Laboratory; University of New South Wales Sydney; University of New South Wales Sydney; University of New South Wales Sydney; University System of Georgia; Georgia Institute of Technology; Western University (University of Western Ontario)
摘要：Globally, cities face increasing extreme heat, impacting comfort, health, and energy consumption. Infrastructure- based heat adaptation strategies can improve these outcomes, but each strategy has a unique mix of benefits and drawbacks. Here, we apply an urbanized meteorological model (WRF) with the newly integrated multilayer BEP- Tree street tree model to dynamically downscale Earth System Model projections and a 3- D microclimate model (TUF- Pedestrian) to simulate the street- scale radiati...
