22期

最新文章

• Ecological restructuring of North Tethyan marine vertebrate communities triggered by the end- Cretaceous extinction AI翻译
  作者：Feichtinger, Iris; Harzhauser, Mathias; Pollerspock, Jurgen; Auer, Gerald; Coric, Stjepan; Kranner, Matthias; Kallanxhi, Madalina-Elena; Weinmann, Anna E.; Guinot, Guillaume
  作者单位：University of Graz; Centre National de la Recherche Scientifique (CNRS); Institut de Recherche pour le Developpement (IRD); Universite de Montpellier; Institut Universitaire de France
  摘要：The ecological upheavals produced by the Cretaceous-Paleogene mass extinction event (K-Pg, -66 Ma) have been mostly studied at large scale with emphasis on clades' diversity dynamics. How this event affected the structure of paleocommunities is comparatively less investigated, especially within large vertebrate clades like fish. Here, we quantified changes in the contribution of elasmobranchs (sharks, skates, rays) and actinopterygians (ray-finned fishes) to the fish community across the K-Pg ...
• Exploring diverse supramolecular tessellation through hierarchical assemblies of nonalternant nanographene AI翻译
  作者：Sun, Jian; Deng, Ziqi; Phillips, David Lee; Liu, Junzhi
  作者单位：University of Hong Kong; Chinese Academy of Sciences; University of Hong Kong; University of Hong Kong; The University of Hong Kong Shenzhen Institute of Research & Innovation; University of Hong Kong
  摘要：Tessellation, as an ancient and fascinating mathematical pursuit, has not only captivated mathematicians but also has attracted chemists' increasing attention at the molecular level in recent years. Exploring tessellation at the molecular scale is pivotal for gaining profound insights into the effects of tessellation on materials and elucidating the essential design principles for supramolecular tessellation. In this study, we develop a dynamic fullerene host (1) with three consecutive heptago...
• Surface melting-driven hydrogen absorption for high-pressure polyhydride synthesis AI翻译
  作者：Sato, Ryuhei; Conway, Lewis J.; Zhang, Di; Pickard, Chris J.; Akagi, Kazuto; Sau, Kartik; Li, Hao; Orimo, Shin - ichi
  作者单位：Tohoku University; University of Tokyo; University of Cambridge; National Institute of Advanced Industrial Science & Technology (AIST); Tohoku University; Tohoku University
  摘要：The synthesis of new polyhydrides with high superconducting Tc is challenging owing to the high pressures and temperatures required. In this study, we used machine-learning potential molecular dynamics simulations to investigate the initial stage of polyhydride formation in calcium hydrides. Upon contact with high-pressure H2, the surface of CaH2 melts, leading to CaH4 formation. This surface melting proceeds via CaH4 liquid phase as an intermediate state. High pressure reduces not only the hy...
• Microscale technologies for tissue engineering and biology (vol 103, 2480-2487, 2006). AI翻译
  作者：Khademhosseini, Ali; Langer, Robert; Borenstein, Jeffrey; Vacanti, Joseph P.
• The proofreading mechanism of the human leading- strand DNA polymerase ε holoenzyme AI翻译
  作者：Wang, Feng; He, Qing; O'Donnell, Michael E.; Li, Huilin
  作者单位：Van Andel Institute; Rockefeller University; Howard Hughes Medical Institute; Rockefeller University
  摘要：The eukaryotic leading-strand DNA polymerase epsilon(Pol epsilon) is a dual-function enzyme with a proofreading 3 '-5 ' exonuclease (exo) site located 40 & Aring; from the DNA synthesizing pol site. Errors in Pol epsilon proofreading can cause various mutations, including C-to-G trans-versions, the most prevalent mutation in cancers and genetic diseases. Pol epsilon interacts with all three subunits of the PCNA ring to assemble a functional holoenzyme. Despite previous studies on proofreading ...
• Viral and host network analysis of the human cytomegalovirus transcriptome in latency AI翻译
  作者：Collins-McMillen, Donna; Pessoa, Diogo De Oliveira; Zarrella, Kristen; Parkins, Christopher J.; Daily, Michael; McKinzey, David R.; Moorman, Nathaniel J.; Kamil, Jeremy P.; Caposio, Patrizia; Padi, Megha; Goodrum, Felicia D.
  作者单位：University of Arizona; University of Arizona; University of Arizona Health Sciences; Arizona Center Cancer Care; University of Arizona; Oregon Health & Science University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Louisiana State University System; Louisiana State University Shreveport; Louisiana State University Health Sciences Center at Shreveport; University of Arizona; University of Arizona Health Sciences; University of Arizona
  摘要：The human cytomegalovirus (HCMV) UL135 and UL138 genes play opposing roles regulating latency and reactivation in CD34+ human progenitor cells. We designed an RNA sequencing study to compare the transcriptional profile of HCMV infection in the presence and absence of these genes using the Tohoku Hospital Pediatrics-1 (THP-1) monocytic cell line model for latency. Relative to primary cell models, THP-1 cells offer the strength of a homogenous population that uniformly silences gene expression a...
• Alternative cGAS signaling promotes herpes simplex encephalitis AI翻译
  作者：Shmuel-Galia, Liraz; Jiang, Zhaozhao; Stine, Laurel; Cahill, Sara; Ng, Sze - Ling; Wilson, Ruth; Kandasamy, Richard Kumaran; Kurt-Jones, Evelyn A.; Ramanjulu, Joshi M.; Bertin, John; Kasparcova, Viera; Pesiridis, G. Scott; Fitzgerald, Katherine A.; Humphries, Fiachra
  作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; GlaxoSmithKline; Glaxosmithkline USA; Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU); University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester; Sanofi-Aventis; Sanofi USA
  摘要：During infection, foreign DNA is sensed by cyclic GMP-AMP synthase (cGAS) leading to the production of cGAMP, STING-dependent type I interferon and proinflammatory cytokine expression, and autophagy. To prevent a response to self-DNA, cGAS activity is tightly regulated. Dysregulation of cGAS underpins interferonopathies, such as Aicardi-Gouti & egrave;res syndrome, as well as Lupus and neurodegenerative diseases like Parkinson's disease. Thus, cGAS and its product cGAMP are therapeutic targets...
• ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D AI翻译
  作者：Bhandari, Nilam; Prince, Ashutosh; Khan, Mariam R.; Traughber, C. Alicia; Neupane, Kalash; Lorkowski, Shuhui W.; Brubaker, Gregory; Ertugral, Elif G.; Kothapalli, Chandrasekhar R.; Dubyak, George R.; Smith, Jonathan D.; Gulshan, Kailash
  作者单位：University System of Ohio; Cleveland State University; University System of Ohio; Cleveland State University; Cleveland Clinic Foundation; University System of Ohio; Cleveland State University; University System of Ohio; Case Western Reserve University
  摘要：Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis, with symptoms including pruritus, pancreatitis, fat malabsorption, intestinal inflammation, and failure to thrive. High-throughput studies showed interconnection between ATP8B1 and phosphoinositide (PIPs), but the mechanism linking ATP8B1, lipid metabolism, and inflammation remains unclear. Atp8b1G308V/G308Vmouse model, unbiased RNAseq, high-resolution-stimulation emission depltion (STED)-microscopy, and Crispr-Cas9 gener...
• Proofreading and single- molecule sensitivity in T cell receptor signaling by condensate nucleation AI翻译
  作者：White, William L.; Yirdaw, Hailemikael K.; Ben-Sasson, Ariel J.; Groves, Jay T.; Baker, David; Kueh, Hao Yuan
  作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of California System; University of California Berkeley; Nanyang Technological University; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
  摘要：T cells display the remarkable ability to detect single foreign peptides displayed on target cells, while ignoring highly abundant self-peptides. This selectivity has been explained by kinetic proofreading in the T cell receptor (TCR) signaling pathway, which prevents responses to short-lived binding events regardless of their abundance. However, the biochemical mechanisms that drive kinetic proofreading have remained unclear. Here, using computational modeling, we show that these key signalin...
• Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 AI翻译
  作者：Zhang, Sitao; Megarioti, Amalia H.; Hendricks, Joseph M.; Zhou, Junshu; Sun, Qingxiang; Jia, Da; Olzmann, James A.
  作者单位：Sichuan University; University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of Electronic Science & Technology of China; Sichuan Provincial People's Hospital
  摘要：FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 and vitamin K. These quinone antioxidants function as radical scavenging agents that prevent the propagation of lipid peroxidation and the induction of ferroptosis. Although several small-molecule inhibitors of FSP1 have been developed and found to sensitize cancer cells to ferroptosis, our understanding of their molecular mechanisms remains limited...