23期

最新文章

• Natural dispersal is better than translocation for reducing risks of inbreeding depression in eastern black rhinoceros (Diceros bicornis michaeli) AI翻译
  作者：Mellya, Ronald. V. K.; Hopcraft, J. Grant C.; Mwakilema, William; Eblate, Ernest M.; Mduma, Simon; Mnaya, Bakari; Chuma, Idrissa S.; Macha, Emmanuel S.; Wambura, Dickson; Fyumagwa, Robert D.; Kilbride, Elizabeth; Ijaz, Umer Z.; Mable, Barbara K.; Khan, Anubhab
  作者单位：University of Glasgow; University of Glasgow; Indian Institute of Science (IISC) - Bangalore
  摘要：Due to increasing anthropogenic impacts, many species survive only in small and isolated populations. Active conservation management to reduce extinction risk includes increasing habitat connectivity, translocations from captive populations, or intensive surveillance of highly protected closed populations. Advances in sequencing technology mean that it is now possible to consider the genomic impacts of such strategies, as a proxy for variation in individual fitness. Using whole genome sequence...
• Creb5 controls its own expression and directly induces the joint interzone regulatory program AI翻译
  作者：Zhang, Cheng- Hai; Shahini, Aref; Cook, Laura E.; Mistry, Meeta; Kim, Jongkil; Wick, Heather; Pennacchio, Len A.; Lassar, Andrew B.
  作者单位：Harvard University; Harvard Medical School; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Harvard University; Harvard T.H. Chan School of Public Health
  摘要：Prior studies have indicated that the transcription factor Creb5 is expressed in the joint interzone, which contains the progenitors for all synovial joint tissues in both mouse and human embryos. In the absence of Creb5 function, most synovial joint interzones fail to form and the cartilage templates in the long bones remain fused. This earlier work did not clarify whether Creb5 initiates a cascade of signaling molecules, such as growth and differentiation factor 5 (Gdf5) and Wnt- family memb...
• Assembly and activation of the death-inducing signaling complex AI翻译
  作者：Fosuah, Elizabeth; Shen, Zhangfei; Xie, Jiale; Wang, Chen; Lin, Qingpeng; Fu, Tian-Min
  作者单位：University System of Ohio; Ohio State University; University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
  摘要：The death-inducing signaling complex (DISC), comprising Fas, Fas-associated death domain (FADD), and caspase-8, initiates extrinsic apoptosis. Using cryogenic electron microscopy (cryo-EM), we show that Fas and FADD death domains (DDs) form an asymmetric 7:5 oligomer, which promotes FADD death effector domain (DED) filament formation. Structural analysis reveals that FADD DED filaments closely resemble caspase-8 tandem DED filaments, suggesting that FADD DED serves as a nucleation scaffold for...
• Light at night negatively affects mood in diurnal primate- like tree shrews via a visual pathway related to the perihabenular nucleus AI翻译
  作者：Miao, Ying; Zhao, Huan; Li, Yu-Fei; Sun, Yan-Ping; Bi, Rui; Li, Hongli; Fang, Xin; Li, Zi-Shuo; Ma, Yu-Hua; Lv, Long-Bao; An, Kai; Meng, Jian-Jun; Yao, Yong-Gang; Xue, Tian
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Hefei University; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
  摘要：To better understand the potential health threats and underlying visual pathways of long-term light at night (LAN) exposure, we adopted a widely accepted diurnal animal model tree shrew (Tupaia belangeri chinensis), which is a close relative to primates, and evaluated the deleterious effects of long-term LAN exposure. We used an early-night LAN paradigm that was established in mice to examine behavioral and physiological consequences in adult male tree shrews. We found that 3-wk LAN exposure s...
• Dynamic relocation of PKA regulatory subunits during sperm capacitation: Linking PKA to the CatSper signaling complex AI翻译
  作者：Novero, Analia G.; Volante, Arturo Matamoros -; Gomez -Olivieri, Lucila R.; Stival, Cintia; Luque, Guillermina M.; Szalai, Alan M.; Ambrosio, Andrea L.; Stefani, Fernando D.; Buffone, Mariano G.; Krapf, Dario; Krapf, Diego
  作者单位：National University of Rosario; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Rosario; Colorado State University System; Colorado State University Fort Collins; Colorado State University System; Colorado State University Fort Collins; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); Colorado State University System; Colorado State University Fort Collins; University of Buenos Aires
  摘要：To fertilize an oocyte, mammalian spermatozoa must undergo a maturation step known as capacitation that takes place after ejaculation. Protein kinase A (PKA) plays a fundamental role in capacitation in all mammalian species. Before capacitation, PKA is maintained in an inactive state where the catalytic subunits are bound to a dimer of inhibitory regulatory subunits. A key element in the regulation of PKA lies in its intracellular compartmentalization achieved by docking at A-kinase anchoring ...
• The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response AI翻译
  作者：Pandher, Ruby; Xue, Chengyuan; Gamble, Laura D.; Milazzo, Giorgio; Di Giacomo, Simone; Murray, Jayne; Cheung, Leanna; Ferrucci, Francesca; Palombo, Marta; Purgato, Stefania; Burkhart, Catherine A.; Fedtsova, Natalia; Gleiberman, Anatoli S.; Purmal, Andrei A.; Korotchkina, Lioubov; Nikiforov, Mikhail A.; Makarov, Sergei S.; Telfer, Thomas J.; Codd, Rachel; Marshall, Glenn M.; Scott, David A.; Osterman, Andrei L.; Gudkov, Andrei, V; Perini, Giovanni; Haber, Michelle; Norris, Murray D.
  作者单位：University of New South Wales Sydney; Children's Cancer Institute; University of Bologna; Roswell Park Comprehensive Cancer Center; University of Sydney; University of Sydney; NSW Health; Sydney Childrens Hospitals Network; Sanford Burnham Prebys Medical Discovery Institute; University of New South Wales Sydney
  摘要：Despite Myc oncoproteins being major causal factors in human cancer, they remain undruggable. The MYCN oncogene is one of the most powerful prognostic markers for the childhood cancer neuroblastoma and represents an important target for developing novel therapeutics. Here, we report the finding and characterization of M606, a selective small molecule inhibitor of MYCN, which was identified by screening a diverse chemical library. M606 reduced MYCN protein levels in neuroblastoma cell lines and...
• Controlling DNA-RNA strand displacement kinetics with base distribution AI翻译
  作者：Ratajczyk, Eryk J.; Bath, Jonathan; Sulc, Petr; Doye, Jonathan P. K.; Louis, Ard A.; Turberfield, Andrew J.
  作者单位：University of Oxford; University of Oxford; University of Oxford; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Arizona State University; Arizona State University-Tempe; Technical University of Munich; University of Oxford
  摘要：DNA-RNA hybrid strand displacement underpins the function of many natural and engineered systems. Understanding and controlling factors affecting DNA-RNA strand displacement reactions is necessary to enable control of processes such as CRISPR-Cas9 gene editing. By combining multiscale modeling with strand displacement experiments, we show that the distribution of bases within the displacement domain has a very strong effect on reaction kinetics, a feature unique to DNA-RNA hybrid strand displa...
• Programmable seconds- to- days- long delayed snapping in jumping metashells AI翻译
  作者：Qing, Haitao; Zhou, Caizhi; Qi, Fangjie; Yin, Jie
  作者单位：North Carolina State University
  摘要：Shape- shifting structures can transform and recover their shapes in response to external stimuli, but they often lack programmable, clock- like control over spatiotemporal deformation and motion, especially after stimuli are removed. Achieving autonomous, time- regulated spatiotemporal motion remains a grand challenge. Here, we present an autonomous delayed- jumping metashell that integrates viscoelastic materials with monostable architected structures to address this limitation. The metashel...
• Reply to Ogutu et al.: Cattle-wild herbivore interaction studies warrant new lenses from community ecology and environmental justice AI翻译
  作者：Butt, Bilal; Xu, Wenjing
  作者单位：University of Michigan; University of Michigan System; University of Michigan; Senckenberg Biodiversitat & Klima- Forschungszentrum (BiK-F); Leibniz Association; Senckenberg Gesellschaft fur Naturforschung (SGN)
• Sensitivity of simulations of Plio-Pleistocene climate with the CLIMBER-2 Earth System Model to details of the global carbon cycle AI翻译
  作者：Carrillo, Judit; Mann, Michael E.; Marinov, Irina; Christiansen, Shannon A.; Willeit, Matteo; Ganopolski, Andrey
  作者单位：University of Pennsylvania; Universidad de la Laguna; Potsdam Institut fur Klimafolgenforschung
  摘要：The Earth system model CLIMBER-2 has been used in past work to successfully reproduce the glacial/interglacial cycles of the Plio-Pleistocene and the Mid-Pleistocene Transition (MPT) from predominantly 40 to 100 ky timescale oscillatory behavior as a function of declining volcanic outgassing and regolith removal. In this study, we further examine the sensitivity of this previous work to varying prescribed levels of volcanic outgassing and regolith extent and the long-term dynamics of the globa...